Category: 161357-89-7piperazines

161357-89-7, 1-(Methylsulfonyl)piperazine hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5 6- [3-(4-MethanesuIfonyl-piperazin-l-vImethyl)-phenyn -2- morpholin-4-vI-[4,5’lbipyrimidinyl-2>-ylamine (38)Intermediate Cl (lOOmg, 0.33mmol) and Intermediate G (1.2 equiv., 80mg) were taken up in 1,2-dichloroethane (5ml). To this was added sodium triacetoxyborohydride (2.4equiv., 170mg) and trimethyl orthoformate (0.1ml) and the reacton mixture was stirred at room temperature overnight. Purification by DCM/aqueous NaHCO3 extraction, SCX-2 cartridge and flash chromatography gave 4- {4-chloro-6-[3-(4-methanesulfonyI-piperazin- 1 -ylmethyl)-phenyl]-pyrimidin-2-yl} – morpholine as a white solid (95mg). 4- {4-Chloro-6- [3 -(4-methanesulfonyl-piperazin- 1 -y lmethyl)-phenyl] -pyrimidin-2-yl } – morpholine (90mg, 0.20mmol) and 2-aminopyrimidine-5-boronic acid pinacol ester (1.8 equiv., 80mg) were taken up in acetonitrile (3ml). To this were added sodium carbonate (3 equiv., 64mg) as a solution in water (ImI) and PdCl2(PPh3)2 (0.05 equiv.). The reaction mixture was heated in microwave at 14O0C for 30 min. Purification using SCX- 2 cartridge, flash chromatography and trituration with hot DCM gave the title compound as a white solid (105mg).NMR (CDC13): 2.61-2.64 (4H, m), 2.81 (3H, s), 3.27-3.30 (4H, m), 3.67 (2H, s), 3.84- 3.87 (4H, m), 4.00-4.03 (4H, m), 5.32 (2H, br), 7.28 (IH, s), 7.47-7.49 (2H, m), 7.99 (IH, s), 8.01-8.04 (IH, m), 9.04 (2H, s) MS (ESI+): MH+ 511.17 (100%)., 161357-89-7

161357-89-7 1-(Methylsulfonyl)piperazine hydrochloride 16265612, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; WO2009/66084; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.

1- (Methylsulfonyl) piperazine hydrochloride (1.07 mmol) was added to acetonitrile (5 ml) and potassium carbonate (1.16 mmol) was added followed by 3-phenylpropyl isocyanate (1.07 mmol). The reaction mixture was stirred at room temperature for 8 hours. After the reaction was completed, water was added and extracted with ethyl acetate. The organic layer was concentrated and purified by column chromatography to give the title compound., 161357-89-7

161357-89-7 1-(Methylsulfonyl)piperazine hydrochloride 16265612, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; The Industry & Academic Cooperation in Chungnam National University (IAC); Jung, Sang-Hun; Woo, Sun-Hee; Kim, Sang- Kyum; Jeon, Eun-Seok; Lee, Yu-Jung; Meunikam, Manoj; Jalani, Hiteshkumar; Sharma, Niti; (205 pag.)KR2016/108281; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.

1- (Methylsulfonyl) piperazine hydrochloride (1.07 mmol) was added to acetonitrile (5 ml) and potassium carbonate (1.16 mmol) was added followed by 3-phenylpropyl isocyanate (1.07 mmol). The reaction mixture was stirred at room temperature for 8 hours. After the reaction was completed, water was added and extracted with ethyl acetate. The organic layer was concentrated and purified by column chromatography to give the title compound., 161357-89-7

161357-89-7 1-(Methylsulfonyl)piperazine hydrochloride 16265612, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; The Industry & Academic Cooperation in Chungnam National University (IAC); Jung, Sang-Hun; Woo, Sun-Hee; Kim, Sang- Kyum; Jeon, Eun-Seok; Lee, Yu-Jung; Meunikam, Manoj; Jalani, Hiteshkumar; Sharma, Niti; (205 pag.)KR2016/108281; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics