Category: 16004-15-2

Recommanded Product: 16004-15-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Spectroscopic, structural and anticancer activity studies of (-)-cytisine halogenated N-benzyl derivatives.

(-)-Cytisine and its derivatives, characterized by high affinity to neuronal nicotinic acetylcholine receptors (nAChRs), have been shown to be important probes in the research of central nervous system disorders. In this work new halogenated N-benzylcytisine derivatives were obtained, and structurally characterized by NMR spectra and x-ray diffraction. Electron impact mass spectral (EIMS) fragmentations have been investigated and detailed fragmentation pathways have been proposed for all significant ions. For the first time it is shown that cytisine derivatives, under in vitro condition, exhibit promising antiproliferative activities against selected cell lines (A549, MV4-11, NCI-H358, MDA-MB-231, MCF-7, LoVo, HT-29, SK-N-MC). They exhibit lower cytotoxicity against normal murine fibroblasts then cisplatin, the commonly used anticancer drug. N-(4-iodobenzyl)cytisine revealed the strongest antiproliferative activity against lung (NCI-H358) and neuroepithelioma (SK-N-MC; IC50 below 10 μM) cancer cell lines among all compounds studied.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogs, published in 2021, which mentions a compound: 16004-15-2, Name is 1-(Bromomethyl)-4-iodobenzene, Molecular C7H6BrI, Reference of 1-(Bromomethyl)-4-iodobenzene.

Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synthesis of two sulfonate analogs and their incorporation into two thrombin-inhibiting sulfopeptides. The effective mimicry of these sulfonate analogs for native sulfotyrosine was validated in the context of their thrombin inhibitory activity and binding mode, as determined by X-ray crystallog.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16004-15-2, is researched, SMILESS is IC1=CC=C(CBr)C=C1, Molecular C7H6BrIJournal, Journal of Molecular Structure called Inhibition of acid corrosion in API 5L X52 steel with 1,2,3-triazole derivatized from benzyl alcohol: Experimental and theoretical studies, Author is Espinoza Vazquez, A.; Gonzalez-Olvera, R.; Moreno Cerros, D.; Negron Silva, G. E.; Figueroa, I. A.; Rodriguez Gomez, F. J.; Castro, M.; Miralrio, A.; Huerta, L., the main research direction is inhibition acid corrosion steel triazole derivatized benzyl alc.Related Products of 16004-15-2.

This work presents the synthesis of new triazoles derived from benzyl alc. to be used as corrosion inhibitors for API 5L X52 steel in HCl 1M medium. The results showed that all derivatives displayed a better inhibitory capacity than benzyl alc. Electrochem. impedance spectroscopy in conjunction with polarization curves revealed that compound 6 showed the highest inhibitory capacity of all derivatives with 94.2% inhibition efficiency at a concentration of 50 ppm. Furthermore, it was determined that compounds 3, 6 and 7 were inhibitors with anodic behavior and compounds 4 and 5 acted as mixed inhibitors. Benzyl alc. and all its synthesized derivatives fitted the Langmuir adsorption isotherm. The combined adsorption phenomenon was proposed according to the thermodn. parameter values obtained. Dispersion-corrected DFT studies, assuming the cluster approach, obtained free binding energies that matched well with exptl. determined standard adsorption free energies. The mixed physisorption-chemisorption observed was explained in terms of the electrostatic interactions and chem. bonding between the metal surface and the corrosion inhibitor. Finally, compound 6 obtained the largest charge transference to the metal cluster.

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Reference:
Piperazine – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Nucleophilic and Radical Heptafluoroisopropoxylation with Redox-Active Reagents, published in 2021-10-11, which mentions a compound: 16004-15-2, mainly applied to heptafluoroisopropyl ether preparation; hydroxylamine oxidative heptafluoroisopropyl silver heptafluoroisopropylation; conformation; heptafluoroisopropoxylation; nucleophilic reactions; radical reactions; redox-active reagents, Electric Literature of C7H6BrI.

The practical and efficient heptafluoroisopropoxylation reactions through the invention of a series of redox-active N-OCF(CF3)2 reagents e.g., I were described. These reagents were readily prepared from the oxidative heptafluoroisopropylation of hydroxylamines e.g., II with AgCF(CF3)2. The substitutions on the nitrogen atom significantly affected the properties and reactivities of N-OCF(CF3)2 reagents. Accordingly, two types of N-OCF(CF3)2 reagents including I and III were used as OCF(CF3)2 anion and radical precursors, resp. This protocol enables the direct heptafluoroisopropoxylation of a range of substrates, delivering the corresponding products in moderate to excellent yields.

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Osorio, Liseth S.; Ionta, Marisa; Demuner, Antonio J.; de Sousa, Bianca L.; Ferraz, Guilherme O.; Varejao, Eduardo V. V.; Ferreira-Silva, Guilherme A.; Pilau, Eduardo J.; Silva, Evandro; dos Santos, Marcelo H. published an article about the compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2,SMILESS:IC1=CC=C(CBr)C=C1 ).Formula: C7H6BrI. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:16004-15-2) through the article.

In the present study, a series of novel triazole compounds, e.g., I were obtained by conjugation between hydnocarpic acid and functionalized azides via copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC). Hydnocarpic acid and its derivatives were tested against estrogen-pos. breast carcinoma (MCF-7), hepatocellular carcinoma (HepG2), and non-small cell lung cancer (A549) cell lines. The compound I displayed promising antiproliferative activity against A549 cells. It was demonstrated that this compound selectively inhibited the viability of A549 cell cultures. Furthermore, compound I inhibited the clonogenic capacity of A549 cells, and this effect was associated to its ability to inhibit cell cycle progression at G1 phase. These findings indicate that compound I is a promising antitumor agent on A549 cells and support further studies to evaluate the mol. mechanisms underlying its antiproliferative activity. In addition, hydnocarpic acid should be considered as a promising chem. prototype to obtain novel antineoplastic agents.

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Safety of 1-(Bromomethyl)-4-iodobenzene. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Chemo-, regio- and stereoselective synthesis of monofluoroalkenes via a tandem fluorination-desulfonation sequence. Author is Yang, Ren-Yin; Xu, Bo.

A widely applicable approach for the synthesis of Z-monofluoroalkenes ArC(F):CHR [R = Ph, 2-naphthyl, 3-BrC6H4, etc., Ar = Ph, 4-NCC6H4, 4-O2NC6H4, etc.] from readily available alkyl triflones and NFSI was reported. The reaction proceeded under mild conditions, affording the mono-fluorinated alkenes in good to excellent yields with excellent chemo-, regio-, and stereoselectivity. The mechanism might involve electrophilic fluorination of triflones followed by the highly stereoselective concerted bimol. elimination (E2) of CF3SO2H.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Synthesis called Tryptophan N1-alkylation: Quick and simple access to diversely substituted tryptophans, Author is Junk, Lukas; Papadopoulos, Emanuel; Kazmaier, Uli, which mentions a compound: 16004-15-2, SMILESS is IC1=CC=C(CBr)C=C1, Molecular C7H6BrI, Category: piperazines.

The diversification of amino acid sidechains is a major challenge in the synthesis and derivatization of peptides for pharmaceutical applications. We herein present a new protocol to alkylate the indole-nitrogen (N1) of Nα-protected tryptophans. This method provides quick and epimerization-free access to tryptophan derivatives, which can directly be incorporated into peptides. Depending on the functionalities introduced in the side chain, different options for the late-stage modification of peptides are possible.

If you want to learn more about this compound(1-(Bromomethyl)-4-iodobenzene)Category: piperazines, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(16004-15-2).

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Piperazine – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16004-15-2, is researched, SMILESS is IC1=CC=C(CBr)C=C1, Molecular C7H6BrIJournal, Article, Angewandte Chemie, International Edition called Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts, Author is Che, Yuan-Yuan; Yue, Yanni; Lin, Ling-Zhi; Pei, Bingbing; Deng, Xuezu; Feng, Chao, the main research direction is heterobiaryl pyridine preparation electrophilic coupling phosphonium pyridine iodoarene; cross-coupling; palladium; phosphonium salts; pyridines; silver.Name: 1-(Bromomethyl)-4-iodobenzene.

Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ) is researched.Application In Synthesis of 1-(Bromomethyl)-4-iodobenzene.Broloes, Line; Klaue, Kristin; Bendix, Jesper; Grubert, Lutz; Hecht, Stefan; Nielsen, Mogens Broendsted published the article 《Stabilizing Indigo Z-Isomer through Intramolecular Associations of Redox-Active Appendages》 about this compound( cas:16004-15-2 ) in European Journal of Organic Chemistry. Keywords: cross coupling fused ring photochromism sulfur heterocycle supramol isomerization. Let’s learn more about this compound (cas:16004-15-2).

Photoswitchable small mols., such as N,N’-disubstituted indigos, have received great interest within fields such as pharmacol., energy storage, and functional materials, as they represent key building blocks for reversible and non-invasive control of chem. processes. However, to ensure applicability of photochromic systems it is of paramount importance to manipulate the photostationary state. In this work, we achieved this by tethering two redox-active indenofluorene-extended tetrathiafulvalene units to an N,N’-disubstituted indigo photoswitch. Upon two-electron oxidation, we observe significantly enhanced stability of the Z-isomer, compared to the neutral compound, illustrated by a substantial increase in the half-life from 0.48 s to 22 h. This remarkable stabilization is ascribed to formation of strong, intramol. π-dimers between the oxidized subunits.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Discovery of stereospecific cytotoxicity of (8R,8’R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring, published in 2020-07-01, which mentions a compound: 16004-15-2, Name is 1-(Bromomethyl)-4-iodobenzene, Molecular C7H6BrI, Synthetic Route of C7H6BrI.

One of the arctigenin stereoisomers, (8R,8’R)-trans-form 1, showed stereospecific cytotoxicity against insect cells, Sf9 and NIAS-AeAl-2 cells. By the comparison with other stereoisomers, the most importance of the 8’R stereochem. for the higher activities was clarified. On the other hand, the wider range of activity level among stereoisomers against cancer cells, HL-60, was not observed The structure-activity relationship research using derivatives bearing (8R,8’R)-trans-form was performed to show the same level of activities of 3-iodo, 4-iodo, and 3,4-methylenedioxy derivatives 28, 29, and 36 as (8R,8’R)-trans-arctigenin 1. In the examination of thiono derivatives, 4-iodo thiono and 3,4-methylenedioxy thiono derivatives 66, 67 showed similar level of activities to that of (8R,8’R)-trans-arctigenin 1. The expression of ribosomal 28S rRNA gene of Sf9 cells was increased by (8R,8’R)-trans-arctigenin 1, whereas a degradation of DNA was not observed

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