159532-59-9, (S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 43: r(2S)-1-methyl-2-piperazinynmethanol; (2S)-1-{[(1 , 1-dimethylethyl)oxy]carbonyl}-2-piperazinecarboxylic acid (Commercial from ACESYS) (1.03 g, 4.47 mmol) was dissolved in dry Tetrahydrofuran (THF) (25 ml) and cooled to 0C under nitrogen. Lithium aluminium hydride (1 1 ml, 11.00 mmol) was added dropwise and the reaction was stirred at 0C for 15mins and allowed to warm to room temperature. The solution was stirred for ~1 hour at room temperature and then heated at reflux overnight. TLC (20% MeOH/DCM + few drops ammonia; visualised by KMn04) showed the reaction had gone to completion.After cooling, the reaction was cooled to 0C and quenched by the dropwise sequential addition of water (0.5ml), 2M NaOH (0.5ml) and water (1 ml). The resulting slurry was filtered and washed with THF. The filtrate was evaporated in vacuo and the resulting oil was azeotroped with methanol (x2) to give the title compound as colourless oil (374mg)LCMS (Method B): Rt = 0.18 min, MH+ = 131, 159532-59-9
The synthetic route of 159532-59-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; ATKINSON, Francis Louis; ATKINSON, Stephen John; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander G; SHIPLEY, Tracy Jane; WILSON, David Matthew; WATSON, Robert J; WO2012/123312; (2012); A1;,
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