Category: 148546-99-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148546-99-0,3-(4-Methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

EXAMPLE 132 Naphthalene-2-sulfonic Acid [3-(4-Methylpiperazin-1-yl)phenyl]amide (E132) The title compound (E132) was prepared from 3-(4-methylpiperazin-1-yl)benzenamine and naphthalene-2-sulfonyl chloride according to the method of Example 1 MH+=382.

148546-99-0, 148546-99-0 3-(4-Methylpiperazin-1-yl)aniline 11564613, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SmithKline Beecham p.l.c.; US6423717; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

148546-99-0, 3-(4-Methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Chloro-3-nitro-benzene (1.0 g, 7 mmol) is mixed with 1-methyl-piperazine (2.0 mL) and the reaction is capped and stirred at 190 C. for 2 hours. After reaction, the excess 1-methyl-piperazine is removed by rotary evaporation to give the crude product as yellow oil. The crude product is purified by silica gel flash column to give 1.2 g of 1-methyl-4-(3-nitro-phenyl)-piperazine (yield 78%). The 1-methyl-4-(3-nitro-phenyl)-piperazine (1.2 g, 5.4 mmol) is dissolved in methanol (50 mL) and Pd/C (5%, 120 mg) is added to the solution. A hydrogen balloon is attached to the flask. The solution is stirred overnight at room temperature. After the reaction is complete, the Pd/C is filtered and the filtrate collected and concentrated by rotary evaporation, to give 3-(4-methyl-piperazin-1-yl)-phenylamine. 2-Fluoro-6-chloro-9-phenyl-9H-purine (50 mg, 0.20 mmol), 3-(4-methyl-piperazin-1-yl)-phenylamine (42 mg, 0.22 mmol) and diisopropylethylamine (35 muL, 0.2 mmol) are mixed in 1-butanol (0.4 mL). The reaction is stirred at 80 C. for 2 hours before adding trans-1,4-cyclohexanediamine (68 mg, 0.6 mmol) and diisopropylethylamine (70 muL, 0.4 mmol). The reaction mixture is stirred at 110 C. overnight. The solvent is removed by rotary evaporation and the crude product is redissolved in DMSO and purified by HPLC to give N2-(4-amino-cyclohexyl)-N6-[3-(4-methyl-piperazin-1-yl)-phenyl]-9-phenyl-9H-purine-2,6-diamine as a white powder; 1H NMR 400 MHz (DMSO-d6) delta 9.12 (s, 1H), 8.16 (s, 1H), 7.78 (d, 2H, J=6.0 Hz), 7.58 (d, 1H, J=7.6 Hz), 7.42 (m, 2H), 7.24 (m, 2H), 7.00 (t, 1H, J=8.0 Hz), 6.48 (m, 2H), 3.53 (s, 1H), 3.25 (m, 4H), 3.01 (t, 4H, J=4.8 Hz), 2.09 (s, 3H), 1.74 (m, 2H), 1.66 (s, 2H), 0.92 (m, 4H), 0.79 (t, 1H, J=7.2 Hz); MS m/z 498.3 (M+1)., 148546-99-0

The synthetic route of 148546-99-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IRM LLC; US2005/124637; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148546-99-0,3-(4-Methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

Palladium acetate [Pd (OAc) 2] (10 mg, 0.022 mmol, 10%), (~)-BINAP (14 mg, 0.022 mmol, 10%) and dimethylformamide (4 mL) were charged in a round-bottom flask flushed with argon. The mixture was stirred under argon for 30 minutes. Then, 3- (4- METHYLPIPERAZIN-L-YL) phenylamine (84 mg, 0.44 mmol), 8-IODO-1-METHYL-N-[(LS)-2- morpholin-4-yl-1-phenylethyl]-4, 5-dihydro-1H-pyrazolo [4, 3-h]quinazoline-3- carboxamide (120 mg, 0.22 mmol), potassium carbonate (670 mg, 4.85 mmol) and dimethylformamide (1. 5 mL) were added. The resulting mixture was heated at 80C in an oil bath under argon with good stirring for 1.5 hours. After cooling to room temperature, the reaction mixture was poured into water and extracted with dichloromethane. The organic extracts were washed with brine and dried over NA2S04. The solvent was removed under vacuo, the crude was purified by flash chromatography on silica gel (eluant: dichloromethane/methanol 95: 5) to afford 40 mg (30% yield) of the title compound. IH NMR (400 MHz, DMSO-d6) 8 ppm 2.27 (s, 3 H) 2.52 (m, 8 H) 2.80 (t, 2 H) 2.94 (m, 4 H) 3. 13 (m, 4H) 3. 56 (m, 4H) 4. 39 (s, 3H) 5.16 (m, 1 H) 6. 59 (M, 1 H) 7. 14 (m, 1 H) 7.24 (m, 2 H) 7.33 (m, 2 H) 7.42 (m, 2 H) 8.39 (m, 2 H) 9.33 (s, 1 H)., 148546-99-0

As the paragraph descriping shows that 148546-99-0 is playing an increasingly important role.

Reference£º
Patent; PHARMACIA ITALIA S.P.A.; WO2004/104007; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics