Category: 147081-29-6

Electric Literature of 147081-29-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Haruna, Kabiru, introduce new discover of the category.

N,N ‘-Bis-(2-aminoethyl)piperazine functionalized graphene oxide (NAEP-GO) as an effective green corrosion inhibitor for simulated acidizing environment

In this work we evaluated the corrosion inhibition efficacy of N,N’-Bis-(2-aminoethyl)piperazine functionalized graphene oxide (NAEP-GO) against carbon steel in 15% HCl which simulate oil well acidizing environment by weight loss (at ambient and higher temperatures) and electrochemical measurement experiments. The GO was synthesized using waste graphite, after which N,N’ -Bis-(2-aminoethyl)piperazine was grafted onto the GO. Both the GO and NAEP-GO were characterized by FTIR, Raman and TEM techniques. The effect of concentration, temperature and time on the performance of the inhibitor was investigated in this study. The inhibitor efficiency was observed to increase with concentration and a maximum inhibition efficiency of 87% was observed for 25 ppm NAEP-GO at room temperature. The inhibitor exhibited excellent performance at the studied temperatures, however the performance decreases with increase in temperature. The inhibitor showed excellent efficiency of over 80% for all the studied immersion time. The PDP measurement revealed the NAEP-GO to acts predominantly as a cathodic-type inhibitor. The studied compound was observed to obey the Langmuir adsorption isotherm. SEM/EDS, AFM surface morphology and FT-IR analyses of the corrosion product after 24 h’ immersion in the NAEP-GO inhibited solution provide evidence of adsorption of NAEP-GO molecules on the steel surface to form the protective NAEP-GO film that blocked the steel surface from the aggressive acid attack. This study is of importance in solving two main environmental problems, corrosion and the problem of waste disposal as GO was prepared from waste graphite.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Related Products of 147081-29-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Yang, Dong, introduce new discover of the category.

Hyperbranched Poly(ester-enamine) from Spontaneous Amino-yne Click Reaction for Stabilization of Gold Nanoparticle Catalysts

Hyperbranched polymers have garnered much attention due to attractive properties and wide applications, such as drug-controlled release, stimuli-responsive nano-objects, photosensitive materials and catalysts. Herein, two types of novel hyperbranched poly(ester-enamine) (hb-PEEa) were designed and synthesized via the spontaneous amino-yne click reaction of A(2)monomer (1, 3-bis(4-piperidyl)-propane (A(2a)) or piperazine (A(2b))) and B(3)monomer (trimethylolpropanetripropiolate). According to Flory’s hypothesis, gelation is an intrinsic problem in an ideal A(2)+B(3)polymerization system. By controlling the polymerization conditions, such as monomer concentration, molar ratio and rate of addition, a non-ideal A(2)+B(3)polymerization system can be established to avoid gelation and to synthesize soluble hb-PEEa. Due to abundant unreacted alkynyl groups in periphery, the hb-PEEa can be further functionalized by different amino compounds or their derivates. The as-prepared amphiphilic PEG-hb-PEEa copolymer can readily self-assemble into micelles in water, which can be used as surfactant to stabilize Au nanoparticles (AuNPs) during reduction of NaBH(4)in aqueous solution. As a demonstration, the as-prepared PEG-hb-PEEa-supported AuNPs demonstrate good dispersion in water, solvent stability and remarkable catalytic activity for reduction of nitrobenzene compounds.

Related Products of 147081-29-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, Recommanded Product: 147081-29-6, begins with the direct observation of nature¡ª in this case, of matter.147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a document, author is Ercan, A., introduce the new discover.

An allomaltol derivative triggers distinct death pathways in luminal a and triple-negative breast cancer subtypes

Breast cancer is the most common cancer in women that shows a predisposition to metastasize to the distant organs. Kojic acid is a natural fungal metabolite exhibiting various biological activities. Compounds derived from kojic acid have been extensively studied and proved to demonstrate anti-neoplastic features on different cancer types. In the present study, allomaltol-structural analog of kojic acid and its seven derivatives including four novel compounds, have been synthesized, characterized and their possible impact on breast cancer cell viability was investigated. It was discovered that compound 5, bearing 3,4-dichlorobenzyl piperazine moiety, could decrease the viability of both MCF-7 and MDA-MB-231 cell lines distinctively. To ascertain the death mechanism, cells were subjected to different tests following the application of IC50 concentration of compound 5. Data obtained from lactate dehydrogenase activity and gene expression assays pointed out that necrosis had taken place predominantly in MDA-MB-231. On the other hand, in MCF-7 cells, the p53 apoptotic pathway was activated by overexpression of the pro-apoptotic TP53 and Bax genes and suppression of the anti-apoptotic Mdm-2 and Bcl-2 genes. Furthermore, Bax/Blc-2 ratio was escalated by 3.5 fold in the study group compared to the control. Compound 5 did not provoke drug resistance in MCF-7 cells since the Mdr-1 gene expression, drug efflux, and H2O2 content remained unaltered. As for MDA-MB-231 cells, only a 1.4 fold increase in the Mdr-1 gene expression was detected. These results indicate the advantage of the allomaltol derivative over the chemotherapeutic agents conventionally used for breast cancer treatment that can be highly toxic and mostly lead to drug resistance. Thus, this specific allomaltol derivative offers an alternative therapeutic approach for breast cancer which needs further investigation.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 147081-29-6. Recommanded Product: 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a document, author is Yang, Pei-Chia, introduce the new discover, Recommanded Product: 147081-29-6.

Determination of Hg(II) based on the inhibited catalytic growth of surface-enhanced Raman scattering-active gold nanoparticles on a patterned hydrophobic paper substrate

Anthropogenic mercury (Hg) presents serious risks to the surroundings and public health due to its toxicity and bioaccumulation. In this study, a new assay was developed to combat mercury-related issues, and it is based on surface-enhanced Raman scattering (SERS) on an active paper substrate for rapid Hg(II) determination. The sensing principle is based on the hindering effect of Hg(II) on the catalytic growth of SERS-active gold nanoparticles (AuNPs) on a hydrophobically patterned paper substrate. 4-mercaptobenzonic acid (4-MBA) was chosen as an effective Raman reporter molecule, and its Raman signal was enhanced by surface plasmonic 2-[4-(2-hydroxyethel) piperazine-1-yl]ethanesulfonic acid-stabilized gold nanostars (HEPES-AuNSs) on a piece of paper with a hydrophobic surface. After adding a Hg(II) analyte solution to this SERS substrate, an amalgam formed at the solid-liquid interface of the HEPES-AuNSs. The formation of the AuHg amalgam resulted in the dissolution of the branches of the HEPES-AuNSs. In the presence of a growth solution (mixture of Au(III), HCl, and H2O2), the remaining HEPES-AuNSs and the AuHg amalgams acted as seeds to form small AuNPs, resulting in a weak SERS signal of 4-MBA (Raman shift at 1590 cm(-1)). Solution concentration, temperature, and treatment time were optimized to realize a significant decrease in the Raman intensity of 4-MBA when the paper sensor was exposed to Hg(II). The Raman intensity decreased with the increasing concentration of Hg(II) ions in the range of 0.1 nM-1.0 mu M (R-2 = 0.98), with a limit of detection (S/N = 3.0) of 0.03 nM. For practicality, the proposed paper substrate was examined by estimating Hg(II) concentrations in environmental water samples (i.e., seawater and pond water) and the certified standard of SRM 1641d through standard addition and a recovery study. The promising selectivity, sensitivity, and reproducibility of the proposed paper sensor constitute substantial progress toward the portable detecting mercury in real water samples, which can facilitate crucial surrounding monitoring.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 147081-29-6 is helpful to your research. Recommanded Product: 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 147081-29-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Gupta, Anoop K., introduce new discover of the category.

A Three-Dimensional Cu(II)-MOF with Lewis acid-base dual functional sites for Chemical Fixation of CO2 via Cyclic Carbonate Synthesis

A 3D porous Cu(II)-MOF (1), having Lewis acid-base dual-functional sites, has been utilized, whose frameworks have two types of 1D channels decorated with both axially water-bound metal sites and weak base, i.e., tertiary amine groups in the crystallographic c-axis. Upon activation under a high vacuum at 120 degrees C, the axial water molecule is removed and affords a solvent-free and unsaturated Lewis acidic Cu(II) containing framework (1′). The piperazine functionalities from the linkers enhance the selective adsorption of CO2 which, in turn, facilitate the further interaction with the open Cu(II) metal centres, leading to catalytic chemical fixation of CO2 into five-membered cyclic carbonates, in the presence of epoxides and co-catalyst TBAB, under mild and solvent-free reaction conditions. The significance of dual functionalization and the synergy with TBAB on adeptly catalyzed CO2 fixation are explored using several epoxides, and substantial conversion is achieved. Moreover, the catalyst 1′ displays satisfactory stability and easy recyclability for five consecutive cycles without any appreciable loss in its catalytic activity. The results are compared with various MOFs based catalysts at the closest reaction conditions and, based on literature and experimental inferences, a possible mechanism of chemical fixation of CO2 with epoxide catalyzed by 1′ has been proposed.

Reference of 147081-29-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, molecular formula is C10H20N2O2, belongs to piperazines compound, is a common compound. In a patnet, author is Gohain, Moucham Borpatra, once mentioned the new application about 147081-29-6, Product Details of 147081-29-6.

Development of thin film nanocomposite membrane incorporated with mesoporous synthetic hectorite and MSH@UiO-66-NH2 nanoparticles for efficient targeted feeds separation, and antibacterial performance

Functionalized metal-organic frameworks (MOFs) and their composites are found one of the best material to develop the thin-film nanocomposite (TFN) membranes and concern water purification technologies with boosted water flux and targeted feeds rejection performance. MOFs with suitable functionalities are found more stable and efficient due to strong interfacial polymerization with free functional groups which consequently resulted in a thin selective nanocomposite layer on the surface of polysulfone flat sheet membranes. Similarly, mesoporous synthetic hectorite (MSH), due to negative surface charge acts as the best support material to avoid high agglomeration of positively charged MOF crystals. Additionally, surface hydroxyl functionalities with high dispersion capability in a polymer monomer solution makes MSH as a promising material for MOF support and development of novel membranes. Herein considering all these advantageous aspects of both material, we have established a novel approach for developing of TFN membranes by incorporating MSH, and composite of MSH and MOF (UiO-66-NH2) nanoparticles in piperazine (PIP) aqueous monomer solution, which were further interfacially polymerized with trimesoyl chloride (TMC) organic phase monomer. The developed nanoparticles (MSH and MSH@UiO-66-NH2) formulation were confirmed by ideal characterization techniques such as, PXRD, FTIR, TGA and SEM. Whereas, alteration impact of MSH and MSH@UiO-66-NH2 nanoparticles on prepared membranes were physicochemically evaluated with original TFC membrane by ATR-FTIR, FE-SEM, HR-TEM, AFM, XPS, TGA, zeta potential and contact angle analysing techniques. The efficacy performance of the developed TFN membranes were compared with thin-film composite (TFC) membrane and found that TFN membranes showed excellent water flux and rejection performances against different synthetic feed solutions including most common salts (i. e. NaCl, Na2SO4, CuSO4, MgSO4, MnSO4), toxic boron in the seawater and bulky humic substances. Interestingly upon incorporation of a small amount of (0.01%) MSH and MSH@UiO-66-NH2 nanoparticles into the developed membrane dramatically improved rejection performance against applied feed solutions in the trend of TFC < MSH-TFN < MSH@UiO-66-NH2-TFN. The highest rejection 94.42% for MgSO4 was obtained along with the flux 34.78 L/m(2).h at 1.5 MPa. Likewise, 69.56 L/m(2).h flux with 71.23% rejection for boron at pH 8 (close to sea water) at 1.5 MPa. Due to hydrophilic and notable antifouling nature of TFN membranes the tested membrane shows excellent humic acid permeate flux of 80.68 L/m(2).h and rejection of 98.96%. Besides, MSH@UiO-66-NH2-TFN membrane showed noteworthy antibacterial properties with efficient reduction in the bacterial colony growth. We believed that the present novel membrane modification approach has high potential in the development of high efficient water purification technologies in future. If you¡¯re interested in learning more about 147081-29-6. The above is the message from the blog manager. Product Details of 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of (S)-tert-Butyl 3-methylpiperazine-1-carboxylate147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Kandula, Madhu Kumar Reddy, introduce new discover of the category.

Synthesis, antioxidant activity, and alpha-glucosidase enzyme inhibition of alpha-aminophosphonate derivatives bearing piperazine-1,2,3-triazole moiety

A novel series of piperazine-1,2,3-triazole bearing dimethyl(((2-(4-((1H-1,2,3-triazole-4-yl)methyl)piperazin-1-yl)ethylamino)(2-hydroxyaryl)methyl)phosphonate derivatives have been prepared via copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) (Click Reaction) and Schiff base reactions. The synthesized compounds were confirmed by spectral characterization (H-1,C-13 and(31)P NMR, and mass). The title compounds were evaluated for in vitro alpha glucosidase enzyme inhibition and in vitro antioxidant activity using DPPH and H(2)O(2)methods.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 147081-29-6. Quality Control of (S)-tert-Butyl 3-methylpiperazine-1-carboxylate.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Yamasaki, Tomoteru, once mentioned the application of 147081-29-6, Recommanded Product: 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, molecular formula is C10H20N2O2, molecular weight is 200.278, MDL number is MFCD02683204, category is piperazines. Now introduce a scientific discovery about this category.

Development of an In Vivo Method to Estimate Effective Drug Doses and Quantify Fatty Acid Amide Hydrolase in Rodent Brain using Positron Emission Tomography Tracer [C-11]DFMC

Fatty acid amide hydrolase (FAAH) is a key enzyme in the endocannabinoid system. N-(3,4-Dimethylisoxazol-5-yl)piperazine-4-(4-(2-fluoro-4-[C-11]methylphenyl)thiazol-2-yl]-1-carboxamide ([C-11]DFMC) was developed as an irreversible-type positron emission tomography (PET) tracer for FAAH. Here, we attempted to non invasively estimate rate constant k(3) (rate of transfer to the specifically-bound compartment) as a direct index for FAAH in the rat brain. First, the two-tissue compartment model analysis including three parameters [K-1-k(3), two-tissue compartment model for the irreversible-type radiotracer (2TCMi)] in PET study with [C-11] DFMC was conducted, which provided 0.21 +/- 0.04 ml.cm(-3).min(-1 )of the net uptake value (K-i), an indirect index for FAAH, in the FAAH-richest region (the cingulate cortex). Subsequently, to noninvasively estimate K-i value, the reference model analysis (Patlak graphical analysis reference model) was tried using a time-activity curve of the spinal cord. In that result, the noninvasive K-i value (K-REF) was concisely estimated with high correlation (r > 0.95) to K-i values based on 2TCMi. Using estimated K-REF value, we tried to obtain calculated-k(3) based on previously defined equations. The calculated k(3) was successfully estimated with high correlation (r= 0.95) to direct k(3) in 2TCMi. Finally, the dose relationship study using calculated k(3) demonstrated that in vivo ED50 value of [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate, a major inhibitor of FAAH, was 66.4 mu g/kg in rat brain. In conclusion, we proposed the calculated k(3) as an alternative index corresponding to regional FAAH concentrations and suggested that PET with [C-11]DFMC enables occupancy study for new pharmaceuticals targeting FAAH. SIGNIFICANCE STATEMENT In the present study, we proposed calculated k(3) as an alternative index corresponding with fatty acid amide hydrolase concentration. By using calculated k(3), in vivo ED(50 )of [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate was successfully estimated to be 66.4 mu g/kg for rats. Thus, we demonstrated the pharmacological utility of positron emission tomography with N-(3,4-dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[C-11]nnethylphenyl)thiazol-2 -yl]-1-carboxamide.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a document, author is Jassem, A. M., introduce the new discover, COA of Formula: C10H20N2O2.

Synthesis of New Drug-Like Piperazine-2,5-diones by the Ugi/Tandem Process Catalyzed by TMSOTf and Their Molecular Docking

A new four-components post-Ugi transformation process has been studied. It provides an efficient access to biologically active piperazine-2,5-dione derivatives in high yield. The framework of piperazine-2,5-dione derivatives has been constructed by a tandem-decarboxylation of alpha-keto carboxylic acids promoted by a green catalyst trimethylsilyl trifluoromethane sulfonate (TMSOTf). Molecular docking study of piperazine-2,5-dione derivatives has been performed with various anticancer target proteins: human androgen receptor (AR) (PDB ID: 1E3G), human steroidogenic cytochrome P450 17A1 (PDB ID: 4NKV), epidermal growth factor receptor 2 HER2 (PDB ID: 3PP0), and estrogen receptor alpha (ER alpha) (PDB ID: 1A52), and has indicated their possible efficient interactions via hydrogen bonds.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 147081-29-6 is helpful to your research. COA of Formula: C10H20N2O2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 147081-29-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Marupati, Siddhartha, introduce new discover of the category.

Synthesis, in vitro and in silico studies of cis-2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl)(pyridin-2-yl)methanone and its derivatives

A series of cis-2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl) (pyridin-2-yl)methanone and its derivatives (8a-g) was synthesized by the reaction of cis-3-(-3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-thieno [3,2-c] pyrazole hydrochloride (7) with substituted picolinic acid (5) in the presence of hexafluorophosphate azabenzotriazole tetramethyl uronium and N,N-diisopropylethylamine. All the compounds were thoroughly characterized by spectral and elemental analysis. They have been screened for their antibacterial activity and docking results of title compounds have been presented.

Reference of 147081-29-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics