Category: 143673-66-9

143673-66-9, (R)-3-Isopropylpiperazine-2,5-dione is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

143673-66-9, Example 153. (2R)-2-(l-Methylethyl)piperazine (153); CH3H3CHNQNH[0540] A solution of (i?)-(-)-3-isopropyl-2,5-piperazinedione (1.0 g, 6.40 mmol) in THF(30 mL) was treated with LAH (25.6 mL, 25.6 mmol, 1.0 M in THF) and warmed to reflux for 16 h. The reaction mixture was then cooled to 0 C and quenched via the addition of water (2 mL), 4 M NaOH (2 mL), and more water (6 mL). On stirring the resultant suspension at it for 1 h, the mixture was dried (Na2SO4), filtered and the filter cake washed with THF (150 mL). The combined filtrates were evaporated to afford the title product as a pale orange semi-solid: 1H NMR deltaH (250 MHz, CDCl3) 2.90 (2H, dd), 2.70 (2H, m), 2.35 (2H, dd), 2.30 (IH, m), 2.22 (2H, br s), 1.48 (IH, m), 0.89 (3H, d), 0.86 (3H, d).

The synthetic route of 143673-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PANACOS PHARMACEUTICALS, INC.; NITZ, Theodore, J.; SALZWEDEL, Karl; FINNEGAN, Catherine; WILD, Carl; BRUNTON, Shirley; FLANAGAN, Stuart; MONTALBETTI, Christian; COULTER, Thomas, Stephen; KIMBER, Marc; MAGARACI, Filippo; JOHNSTON, David; WO2008/134035; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics