Category: 142-64-3

Pfister, William R. et al. published their research in National SAMPE Symposium and Exhibition, [Proceedings] in 1985 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of Piperazine Dihydrochloride

Silicone-based sustained- and controlled-release drug delivery systems was written by Pfister, William R.;Sweet, Randall P.;Walters, Patrick A.. And the article was included in National SAMPE Symposium and Exhibition, [Proceedings] in 1985.Application In Synthesis of Piperazine Dihydrochloride This article mentions the following:

The effects of various classes of therapeutic agents and pharmaceutical excipients on the cure profile and phys. properties of vulcanized liquid silicone rubber (LSR) were evaluated. The results demonstrate the compatibility of LSR as a carrier matrix for a number of classes of therapeutic agents and pharmaceutical excipients. The resultant phys. properties of the LSR drug/excipient matrix are dependent upon the chem. structure and weight percentage loading level of the additive. These studies demonstrate the utility of LSR for fabricating controlled-release drug delivery systems. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Application In Synthesis of Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Bertrand, Didier et al. published their research in Bull. soc. chim. in 1945 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C4H12Cl2N2

Visible fluorescence and chemical structure. III. Double-bond nitrogen compounds and amine hydrochlorides was written by Bertrand, Didier. And the article was included in Bull. soc. chim. in 1945.Electric Literature of C4H12Cl2N2 This article mentions the following:

The double-bond N gives a fluorescence spectrum radically different from those of the amines and anilines studied. The effect of HCl is frequently to alter the intensity but not the shape of the spectral curve of the base. Fluorescence spectra are given for pyridine, quinoline, isoquinoline, acridine, N-benzylidenebenzylamine, N-heptylidenebenzylamine, and the hydrochlorides of pyridine, quinoline, isoquinoline, acridine, N-benzylideneaniline, N-benzylidenebenzylamine, N-benzylidene-β-naphthylamine, β-naphthylamine, carbazole, piperazine, PhNHEt, PhNEt2, 2-phenylethylamine, tetrahydroquinoline, and tetrahydroisoquinoline. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Electric Literature of C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Lunn, George et al. published their research in Synthesis in 1985 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: Piperazine Dihydrochloride

General cleavage of nitrogen-nitrogen and nitrogen-oxygen bonds using nickel/aluminum alloy was written by Lunn, George;Sansone, Eric B.;Keefer, Larry K.. And the article was included in Synthesis in 1985.Recommanded Product: Piperazine Dihydrochloride This article mentions the following:

Addition of Ni-Al alloy to KOH solutions of compounds containing N-N or N-O bonds is a general and convenient means for reducing such compounds to the corresponding amines. The method was successfully applied to the reduction of nitrosamines, hydrazines, hydroxylamines, hydroxylamine ethers, triazenes, nitramines, N-oxides, tetrazenes, and nitroso, azo, and azoxy compounds In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Recommanded Product: Piperazine Dihydrochloride).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Recommanded Product: Piperazine Dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Gu, Dan et al. published their research in Synthetic Metals in 2009 | CAS: 142-64-3

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

Triphenylamine-based pH chemosensor: Synthesis, crystal structure, photophysical properties and computational studies was written by Gu, Dan;Yang, Guochun;He, Yi;Qi, Bin;Wang, Guang;Su, Zhongmin. And the article was included in Synthetic Metals in 2009.Category: piperazines This article mentions the following:

A triphenylamine-containing pH chemosensor, N,N’-di[3-(diphenylamine)benzyl]-piperazine, was designed and synthesized with Ullmann reaction. The compound crystallize in the monoclinic space group P21/n: a = 9.8004(12) Å, b = 13.3321(17) Å, c = 12.9575(16) Å, β = 103.510(2)°, Z = 2 and ρ = 1.212 Mg/m3. The synthesized compound excited by UV light produce intensive emission and a quantum yield of 0.56 relative to quinine sulfate was achieved. The fluorescence intensity of synthesized compound in water/DMF (4:1, volume/volume) under excitation of 307 nm decreased with the decrease of pH, exptl. and computational studies further confirmed that the protonation of N-triphenylamine leads to the fluorescence quenching. The results clearly indicate the potential of synthesized compound as highly efficient on-off switcher for protons. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Category: piperazines).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Some tips on 142-64-3

142-64-3 Piperazine Dihydrochloride 8893, apiperazines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.

A solution of 1-5 – [(3,4-dihydro-4-oxo-l-phthalazinyl) methyl] -2- fluorobenzoic acid (60.0 g, 0.20 mol)Suspended in 600 mL of acetonitrile,Anhydrous piperazine (43.0 g, 0.50 mol)Piperazine dihydrochloride (79.0 g, 0.50 mol)Concentrated sulfuric acid (2.78 ml, 0.04 mol)Heated to 78-80 C under reflux for 7 to 8 hours,Drop to room temperature,Concentrated under reduced pressure acetonitrile, water was added 1000ml, stirred for 30min; concentrated ammonia was added dropwise to a PH value of 7-8, stirred 2h, suction filtration,44.1 g of 1- [5 – [(3,4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine was obtained in a yield of 60.1%.1- [5 – [(3,4-dihydro-4-oxo-1-phthalazin-yl) methyl] -2-fluorobenzoyl] piperazine 1H NMR, (400 MHz) see Figure 1., 142-64-3

142-64-3 Piperazine Dihydrochloride 8893, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Shanghai Pharmaceutical Group Co., Ltd.; Deng Yu; (7 pag.)CN106554316; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Analyzing the synthesis route of 142-64-3

The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.

100 g (1.2 mol) of anhydrous piperazine and 240 g (1.5 mol) of piperazine dihydrochloride were heated to 120 C, and 150 g (1.2 mol) of 2-(2-chloroethoxy)ethanol was added dropwise. After the completion of heating and stirring, the temperature was raised to 136-140 C for 1 hour, and TLC showed that the reaction was completed and then the heating was stopped. When the temperature dropped to 80 degrees Celsius, 500ml of 95% ethanol was added, cooled in the refrigerator overnight, and the piperazine dihydrochloride was recovered by filtration the next day. The filter cake was washed thoroughly with a small amount of ethanol, the filtrate was combined, and 200 g of 30% sodium hydroxide solution was added, alkalized, and the insoluble inorganic salt was filtered off, and concentrated to remove the solvent. The residue was extracted with ethyl acetate, dry hydrogen chloride gas was passed, filtered and dried to give a white solid 1-[2-(2-hydroxyethoxy)ethyl]piperazine hydrochloride. The solid content was already above 98%. After recrystallization from a 90% aqueous solution of ethanol, 207 g of white crystals can be obtained, the yield was 70%, and the content can be more than 99.5%., 142-64-3

The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Wuxi Qianhao Bio-pharmaceutical Co., Ltd.; Peng Haiyan; (4 pag.)CN109400549; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

New learning discoveries about 142-64-3

142-64-3, As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.

217 mg (1 mmol) of alkaloid and 183 mg (1.5 mmol)Monopiperazine hydrochloride was added to 10 mL of methanol and 62 mg (0.1 mmol)In the mixed system of Yb(OTf)3, the reaction was stirred at room temperature for 3 days, and the reaction was completed by TLC.Add 100 mg (1.2 mmol) of NaHCO3 powder and continue to stir for 12 h.Concentrate to dryness under reduced pressure and add 10 mL of benzene to residue.After stirring for 10 min, it was quickly demineralized by a neutral Al2O3 column, concentrated, and purified by silica gel column chromatography (benzene: acetone: ammonia = 10:1:2) to obtain intermediate (III) in a yield of 79%.

142-64-3, As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.

Reference：
Patent; Shijiazhuang College; Zhang Baohua; Shi Lanxiang; (8 pag.)CN109776575; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Analyzing the synthesis route of 142-64-3

142-64-3, The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.

A 250 mL round bottom flask was charged with 20 mmol of compound (4), 80 mL of 1,4-dioxane,20 mmol of compound (2) (R is methyl) was added dropwise at 20 C under stirring for 1 hour. The mixture was heated to reflux for further stirring. After about 6 hours, the solid was no longer increased but changed to distilled. The methanol was distilled off to recover the compound (2) (R is methyl), cooled to below 30 , 40mmol sodium methylate in methanol 30% sodium methoxide was added dropwise over about 1 hour and then stirred for 1 hour, the temperature was rectified methanol were recovered, 1 , 4-dioxane and piperazine (3). The product was distilled off under reduced pressure to give a pale yellow transparent liquid to obtain piperazine methylmethyldimethoxysilane (R is methyl) represented by the formula (1) a, the yield of 95% (as (2) dollars), high performance liquid chromatography analysis content of 98.7%.

142-64-3, The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Yancheng Technology College; Sun Guoxiang; (6 pag.)CN106046041; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Downstream synthetic route of 142-64-3

142-64-3, As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.

142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh Trifluoromethyl acid 9.5g (0.05mol) was dissolved in 20ml of dry tetrahydrofuran, was slowly added CDI8.9g (0.055mol),At room temperature for 4hAfter the reaction solution through a dropping funnel was added dropwise to a solution of constant piperazine dihydrochloride 20g (0.125mol), anhydrous piperazine 10g (0.125mol), 60ml of an aqueous solution of sodium chloride, 14g, and reacted for 5 hours at room temperature .After completion of the reaction by suction, the filtrate evaporated removal of THF, treated 10ml ethyl acetate again, and then a saturated solution of NaOH was adjusted to pH = 10, extracted with ethyl acetate three times and the combined organic phases, the organic phase was dried over anhydrous sodium sulfate overnight, filtration, spin dry ethyl acetate, the resulting white crystals is 1- [3- (trifluoromethyl) benzoyl] crude 6.5g, 50% yield.

142-64-3, As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.

Reference：
Patent; Xi’an Jiaotong University; Zhang, Jie; Lu, Wen; Dong, Jinyun; Pan, Xiaoyan; He, Langchong; Zhang, Tao; Wang, Sicen; Shen, Xiuxiu; (16 pag.)CN104262238; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Brief introduction of 142-64-3

The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

100g of concentrated hydrochloric acid (12mol / L) 250ml round bottom flask was placed in an ice bath, was slowly added 40g of anhydrous piperazine. After addition, the ice bath was removed, the reaction overnight at room temperature, filtered off with suction, the filter cake was placed in an oven dried, the resulting white solid, a piperazine dihydrochloride. 3,4-difluoro-benzoic acid was weighed 7.9g (0.05mol) dissolved in 20ml of dry tetrahydrofuran, was slowly added CDI 8.9g (0.055mol), 4h after the reaction liquid at room temperature through a pressure-equalizing dropping funnel was added dropwise a solution of piperazine dihydrochloride 20g (0.125mol), anhydrous piperazine 10g (0.125mol), 60ml of 14g sodium chloride aqueous solution, at room temperature for 5 hours. After completion of the reaction was suction filtered, the filtrate was evaporated to dryness to remove THF, extracted with ethyl acetate again 10ml, NaOH saturated solution adjusted to pH 10, and the combined organic phase was extracted 3 times with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate overnight, filtered off with suction , rotary evaporation of ethyl acetate, the resulting white crystals which was 1- (3,4-difluoro-benzoyl) piperazine the crude product 5.4g, 48% yield., 142-64-3

The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; XI’AN JIAOTONG UNIVERSITY; ZHANG, JIE; ZHANG, TAO; DONG, JINYUN; PAN, XIAOYAN; HE, LANGCHONG; LU, WEN; WANG, SICEN; SHI, YALING; (19 pag.)CN104262263; (2017); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics