Structure-Activity Relationship Studies of Sulfonylpiperazine Analogues as Novel Negative Allosteric Modulators of Human Neuronal Nicotinic Receptors was written by Henderson, Brandon J.;Carper, Daniel J.;Gonzalez-Cestari, Tatiana F.;Yi, Bitna;Mahasenan, Kiran;Pavlovicz, Ryan E.;Dalefield, Martin L.;Coleman, Robert S.;Li, Chenglong;McKay, Dennis B.. And the article was included in Journal of Medicinal Chemistry in 2011.Formula: C10H14N2O2S This article mentions the following:
Neuronal nicotinic receptors have been implicated in several diseases and disorders such as autism, Alzheimer’s disease, Parkinson’s disease, epilepsy, and various forms of addiction. To understand the role of nicotinic receptors in these conditions, it would be beneficial to have selective mols. that target specific nicotinic receptors in vitro and in vivo. Our laboratory has previously identified novel neg. allosteric modulators of human α4β2 (Hα4β2) and human α3β4 (Hα3β4) nicotinic receptors. The effects of novel sulfonylpiperazine analogs that act as neg. allosteric modulators in both Hα4β2 nAChRs and Hα3β4 nAChRs were investigated. This work, through structure-activity relationship (SAR) studies, describes the chem. features of these mols. that are important for both potency and selectivity on Hα4β2 nAChRs. In the experiment, the researchers used many compounds, for example, 1-(Phenylsulfonyl)piperazine (cas: 14172-55-5Formula: C10H14N2O2S).
1-(Phenylsulfonyl)piperazine (cas: 14172-55-5) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Formula: C10H14N2O2S
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics