Category: 13889-98-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

A solution of 5-fluoro-2-nitroanisole (200 g, 1 eq) and piperazine (302 g, 3 eq) in DMF was stirred for 30 minutes and heated for 12 hours. Acetic anhydride (358 g, 3 eq) was slowly added to the reaction solution, and the reaction solution was stirred at room temperature for 12 hours. Water was added to the reaction solution for dilution, and the solid was filtered and washed twice with water. After drying at 50 C, the product was obtained as a yellow solid (284 g, 87%)., 13889-98-0

As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; Anqing Yuanqi Pharmaceutical Technology Co., Ltd.; Jin Wei; Liu Jinlun; Wang Jianbing; (6 pag.)CN110294721; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 81 2- [3 – (4- Acetyl-piperazin- 1 -yl) -phenyl] -6-chloro-3 ,3 -dimethyl- 1 ,2,3 ,4-tetrahydro- quinoline-8-carboxylic acidTo a mixture of 2-(3-bromo-phenyl)-6-chloro-3,3-dimethyl-l,2,3,4-tetrahydro-quinoline- 8-carboxylic acid methyl ester (410 mg, 1 mmol), palladium acetate (6.73 mg, 0.03 mmol), cesium carbonate (0.65 g, 2 mmol), xantphos (23 mg, 0.04 mmol) and N-acetylpiperazine (192 mg, 1.5 mmol) in toluene (10 mL) was stirred at 120C for 12 hours. Then the reaction mixture was concentrated in vacuo and the residue was extracted with ethyl acetate (2 x 100 mL), washed with saturated aqueous sodium chloride (2 x 50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo. Purification on flash silica gel chromatography (silica gel from QingDao, 200-300 mesh, glass column from Shanghai SD company)(20% ethyl acetate/hexanes) to afford 2- [3-(4-acetyl-piperazin-l-yl)-phenyl] -6- chloro-3,3-dimethyl-l,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester (0.25 g, 54%) as a white solid: LC/MS m/e calcd for C25H30CIN3O3 M+: 455.99, observed: 456.1., 13889-98-0

As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; FENG, Lichun; HUANG, Mengwei; LIU, Yongfu; WU, Guolong; WU, Jim, Zhen; ZHOU, Mingwei; WO2011/128251; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Fluoro-2-methoxy-1-nitrobenzene (2.55 g, 14.9 mmol),N-acetylpiperazine (1.91 g, 14.9 mmol),Potassium carbonate (2.47 g, 17.9 mmol)Was added to N, N-dimethylacetamide (25 mL).The reaction was heated to 120 C for 5 hours. Ethyl acetate (50 mL) was added and the mixture was washed with saturated brine (50 mL). The organic layer was dried, dried and column chromatographed (petroleum ether: ethyl acetate = 5: 1) to give the product as a white solid (1.87 g, yield 45.0 %).

13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd; Wu, Yongqian; (68 pag.)CN105884695; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,13889-98-0

To a 500 mL round bottom flask with a mechanical stirrer, temperature probe and under a nitrogen atmosphere was added N-acetylpiperazine (10 g, 80 mmol), DMF (150 mL), K2CO3 (16.6 g, 120 mmol) and 4-fluorobenzaldehyde (9.9 g, 80 mmol). The reaction mixture was heated to 100 C. for 20 hours. Followed the reaction by TLC monitoring the aldehyde consumption (Conditions: 20% EtOAc/hexane). After the reaction was complete water (150 mL) was added and cooled to room temperature. Extracted with MTBE (200 mL) and then EtOAc (200 mL). Concentrated the organic layer on the rotovap to yield the product.

As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; Milliken & Company; Valenti, Dominick J.; Dey, Sanjeev K.; Qin, Haihu; Freund, Wesley A.; Miracle, Gregory S.; (24 pag.)US2019/112488; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

The compound of formula 18 (6.0 g, 42.5 mmol) was added to the reaction flask at room temperature,24 mL of N, N-dimethylacetamide,1-acetylpiperazine 16 (6.5 g, 51.0 mmol)N, N-diisopropylethylamine (7.1 g, 55.3 mmol)90 reaction 4 ~ 5h,TLC monitoring reaction is complete,Down to room temperature,The reaction solution was poured into 180 mL of water,Extracted with ethyl acetate (50 mL x 3)Combined organic layer,Washed with saturated brine,Dried over anhydrous sodium sulfate,The compound of formula 43 (8.8 g) was obtained by steaming,As a pale yellow solid (yield 83.7%).

13889-98-0, The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Zhang Yinsheng; Gao Yong; Ren Jing; Wang Qinglin; Wang Zhao; (67 pag.)CN106905245; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure P. l-[4-(4-Nitro-phenyl)-piperazin-l-yl]-ethanoneA focus microwave vessel was charged with 4-fluoronitrobenzene (leqv, 1.41 g, 10 mmol), acetylpiperazine (leqv, 1.28 g, 10 mmol), DIPEA (leqv, 1.7 ml, 10 mmol) and propan-2-ol (2 ml). The reaction mixture was irradiated (100W) at 9O0C for 25 mins. A yellow precipitate formed on cooling, which was collected by filtration, washed with propan-2-ol (20 ml) and dried under vacuum to give the product (1.401 g, 56%, 5.6 mmol) as a yellow solid. LC/MS: 100% MH+, m/z 250, Rt = 1.23 mins.

13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; EVOTEC AG; WO2008/122787; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

A solution of 1- (piperazin-1-yl) ethan-1-one (3.59 g, 28 mmol) and potassium carbonate (3.88 g, 28 mmol) were added to N, N-dimethylformamide (40 mL)Then 4-fluoro-2-methoxy-1-nitrobenzene (4.09 g, 23 mmol) was added to the suspension and stirred at 80 C overnight. The mixture was poured into water, The solid precipitate was filtered off. The resulting solid was dried in vacuo at 50 C, A yellow solid (3.5 g, yield: 45%)

13889-98-0, The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Li, Yingxia; Ding, Jian; Xiao, Qiang; Geng, Meiyu; Liu, Jian; Xie, Hua; (24 pag.)CN106608868; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

To a mixture of 3-(6-bromo-quinazolin-4-yl)-5-fluoro-benzoic acid (1.36 g, 3.72 mmol) in CH2CI2 (15 mL) was added DIPEA (1.30 mL, 7.44 mmol) and HBTU (1.694 g, 4.47 mmol) at rt. The reaction mixture was stirred at rt for 20 min. To the mixture was then added 1- (piperazin-l-yl)ethanone (0.572 g, 4.47 mmol) and the reaction mixture was stirred at rt for 1 h. The reaction was quenched with a saturated aqueous solution of NaHC03 and extracted with CH2CI2. The organic layer was washed twice with brine, dried by passing through a phase separating cartridge and evaporated. Purification by Flash chromatography using Biotage Isolera system (amine functionalized silica KP-NH, eluting with Cyclohexane/EtOAc 0 to 100%) gave the title compound (1.20 g, 68% yield) as a beige foam. MS: 457.4-459.3 [M+1]+, Rt(2,) = 1.03 min.

13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOeGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; WO2013/88404; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 18 To a solution of Compound A (0.25 g, 0.60 mmol) in acetonitrile (6 mL) at room temperature were added diisopropylethylamine (0.42 mL, 2.4 mmol) and 1-acetylpiperazine (0.116 g, 0.90 mmol) and the reaction mixture was heated to 80 C. On heating, the reaction mixture became clear and after 15 min commencement of precipitation of solid was observed. Heating was continued for 3 hr and then the reaction mixture was cooled. The solid obtained was collected by filtration, washed with acetonitrile and dried under vacuum. LC/MS: (M+H)+: 503. An NMR spectrum is provided in FIG. 18.Yield: 0.26 g (85%)., 13889-98-0

13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Sudhakar, Anantha; US2011/105497; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 4. 1-{4-[4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(2-chloro-4-methoxyphenoxy)pyrimidin-2-yl]-piperazin-1-yl}ethanone To a solution of 6-[(1H-benzoimidazol-2-ylmethyl)-amino]-4-(2-chloro-4-methoxyphenoxy)-2-(methylsulfonyl)pyrimidine (300 mg, 0.65 mmoles), 1-acetyl piperazine (125 mg, 0.98 mmoles), DMF (4 mL) in a 10 mL microwave vial was added TEA (0.66 mL, 0.65 mmoles). The solution was degassed with N2 for 10 min before being capped and heated in a microwave reactor for 10 min at 120 C. Once complete, the reaction was diluted with 1 M NaOH (10 mL) and EtOAc (20 mL). The EtOAc layer was separated, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude product was submitted for flash chromatography purification. the title compound was obtained in (298 mg, 90% yield). LCMS: 508 (M+H)+. (M+1=508.09, Retention time=2.52; 5-99% CH3 CN/H2 0 gradient with 0.01% TFA).

13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; TRIUS THERAPEUTICS; US2008/194545; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics