Category: 129722-25-4piperazines

129722-25-4, 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of dibenzylcarbamoyl chloride (1.7 g, 6.7 mmol) in pyridine (15 mL) was added dehydro-aripiprazole (1.5 g, 3.4 mmol) and the reaction mixture heated at reflux for 4 h. The reaction mixture was concentrated and the residue co-evaporated with toluene (¡Á3). The residue was dissolved in ethyl acetate (ethyl acetate), washed with water and dried over MgSO4. After evaporation the residue was further purified on silica eluting with ethyl acetate and after drying gave Compound 342 (0.71 g) as a white solid.1H-NMR (300 MHz, CDCl3) delta 8.13 (d, 1H), 7.70 (d, 1H), 7.42-7.29 (m, 11H), 7.20-7.08 (m, 4H), 7.00-6.92 (m, 1H), 4.64 (s, 2H), 4.56 (s, 2H), 4.14 (t, 2H), 3.15-3.02 (m, 4H), 2.74-2.60 (m, 4H), 2.58-2.48 (m, 2H), 1.98-1.88 (m, 2H), 1.83-1.70 (m, 2H). [M+H]+=669.1., 129722-25-4

129722-25-4 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one 10114519, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Alkermes, Inc.; US2011/319422; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129722-25-4,7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one,as a common compound, the synthetic route is as follows.

A mixture of compound 75 (1.2 g) in 4M HCl/dioxane (100 mL) was stirred at RT for 2 h. The solvent was removed under reduced pressure and the residue was dried under vacuum at 50 0C to afford the HCl salt of compound 75 (1.2 g) as a light-yellow solid. 1H-NMR (300 MHz, DMSO-de): delta 1.82-1.92 (m, 4H), 3.12-3.26 (m, 6H)3 3.45 (d, J = 9.4 Hz52H), 3.62 (d, J = 8.5 Hz, 2H), 4.07 (t, J = 5.5 Hz, 2H), 6.32 (d, J = 9.4 Hz, IH), 6.82 (dd, J1 = 4.5 Hz, J2 = 2.4 Hz, 2H), 7.22 (dd, J1 = 6.7 Hz, J2= 2.6 Hz, IH), 7.34-7.41 (m, 2H), 7.58 (d, J = 9.6 Hz, IH), 7.83 (d, J = 9.6 Hz, IH), 10.52 (bs, IH), 11.69 (bs, IH). 13C-NMR (75 MHz, DMSO-de): delta 20.84, 26.46, 48.44, 51.81, 55.84, 67.65, 99.33, 111.47, 114.09, 119.22, 120.53, 126.01, 126.72, 129.37, 129.99, 133.42, 140.76, 141.30, 150.18, 160.94, 162.94. HPLC (method: 20 mm C 18-RP column; mobile phase: 2-95% ACN + 0.1% formic acid in 3.3 min with 1.7 min hold at 95% ACN, Wavelength: 254 ran): retention time: 2.74 min. MS (M + H+): 446.1., 129722-25-4

129722-25-4 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one 10114519, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; CONCERT PHARMACEUTICALS INC.; WO2008/24481; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics