Category: 128019-59-0piperazines

128019-59-0, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 10; Piperazine-1, 2,4-tricarboxylic acid 4-tert-butyl ester 1- (9H-fluoren-9-ylmethyl) ester; A solution of 9-fluorenylmethyl chloroformate (2.72 g, 10.5 mmol) in 1,4-dioxane (19 mL) was added drop-wise to a solution of piperazine-1, 3-dicarboxylic acid 1-tert-butyl ester (2.20 g, 9.6 mmol) and N, N-diisopropylethylamine (4.2 mL, 23.9 mmol) in water (9.5 mL) in an ice-bath. After stirring overnight at room temperature, the reaction mixture was diluted with water and extracted with chloroform (4 times). The organic layer was washed with saturated sodium bicarbonate and water and then 1N HCl and water, dried over anhydrous sodium sulfate, filtered, and concentrated to afford piperazine-1,2, 4- tricarboxylic acid 4-tert-butyl ester 1- (9H-fluoren-9-ylmethyl) ester (4.3g)., 128019-59-0

The synthetic route of 128019-59-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2005/80386; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128019-59-0,4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

61 (B) 4-Methyl-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester The crude piperazine-1, 3-dicarboxylic acid-1-tert-butyl ester (4.92 mmol), prepared as described in 62 (A), was suspended in dry acetonitrile (30 mL) under nitrogen atmosphere and formaldehyde (37% wt. aqueous solution, 367 mL, 4.92 mmol) and Na (OAc) 3BH (2.3 g, 10. 82 mmol) were added. The resulting mixture was stirred at R. T. for 3h, then a saturated aqueous solution of NaHC03 was slowly added until the pH was adjusted to 7. The mixture was concentrated to dryness under reduced pressure to give a yellow solid that was used without further purification for the next step. LCMS (Tr): 3.19 min (Method B); MS (ES+) gave m/z : 245.0., 128019-59-0

As the paragraph descriping shows that 128019-59-0 is playing an increasingly important role.

Reference£º
Patent; ADDEX PHARMACEUTICALS SA; WO2005/44797; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

128019-59-0, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of piperazine-1,3-dicarboxylic acid 1-tert-butyl ester (4.5 g, 19.565 mmol, 1.0 eq) in DCM (125 mL) was added TEA (5.93 g, 58.70 mmol, 3.0 eq) and CbzCl (5 g, 29.35 mmol, 3.0 eq). The mixture was stirred at r.t. for 4 h. The reaction was monitored by LC-MS and TLC. The mixture was concentrated and the resulting residue was purified by chromatography on silica gel column (PE/EA = 5/1) to give (S)-1-((benzyloxy)carbonyl)-4- (tert-butoxycarbonyl)piperazine-2-carboxylic acid (5 g, 70%) as a white solid., 128019-59-0

The synthetic route of 128019-59-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LIFESCI PHAMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (241 pag.)WO2017/98328; (2017); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics