Category: 127116-19-2

COA of Formula: C11H17ClN4OOn May 16, 2019 ,《Synthesis of N-pyrimidin[1,3,4]oxadiazoles and N-pyrimidin[1,3,4]-thiadiazoles from 1,3,4-oxadiazol-2-amines and 1,3,4-thiadiazol-2-amines via Pd-catalyzed heteroarylamination》 appeared in Tetrahedron Letters. The author of the article were Yan, Longjia; Deng, Minggao; Chen, Anchao; Li, Yongliang; Zhang, Wanzheng; Du, Zhi-yun; Dong, Chang-zhi; Meunier, Bernard; Chen, Huixiong. The article conveys some information:

An efficient and practical procedure was developed to prepare various N-pyrimidin[1,3,4]oxadiazole I (R1 = Cl, Ph, N-methylpiperazinyl, etc.; R2 = Me, Ph, C(O)OCH2CH3, etc.; X = O) and thiadiazole scaffolds I (X = S) from 1,3,4-oxadiazol-2-amines II (X = O) and 1,3,4-thiadiazol-2-amines II (X = S) with chloropyrimidines III via Pd-catalyzed heteroarylamination using a Buchwald-type coupling. The products of this reaction are otherwise difficult to access and could be used as building blocks in drug design. After reading the article, we found that the author used 2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol(cas: 127116-19-2COA of Formula: C11H17ClN4O)

2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol(cas: 127116-19-2) belongs to piperazines. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines.COA of Formula: C11H17ClN4O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors》 was written by Francini, Cinzia Maria; Fallacara, Anna Lucia; Artusi, Roberto; Mennuni, Laura; Calgani, Alessia; Angelucci, Adriano; Schenone, Silvia; Botta, Maurizio. Recommanded Product: 127116-19-2 And the article was included in ChemMedChem in 2015. The article conveys some information:

Src family kinases (SFKs) are a family of non-receptor tyrosine kinases (TKs) implicated in the regulation of many cellular processes. The aberrant activity of these TKs has been associated with the growth and progression of cancer. In particular, c-Src is overexpressed or hyperactivated in a variety of solid tumors and is most likely a strong promoting factor for the development of metastasis. Herein, the synthesis of new 4-aminoimidazole and 2-aminothiazole derivatives and their in vitro biol. evaluation are described for their potential use as SFK inhibitors. Initially, 2-aminothiazole analogs of dasatinib and 4-aminoimidazole derivatives were synthesized and tested against the SFKs Src, Fyn, Lyn, and Yes. Five hits were identified as the most promising compounds, with Ki values in the range of 90-480 nM. A combination of mol. docking, homol. modeling, and mol. dynamics were then used to investigate the possible binding mode of such compounds within the ATP binding site of the SFKs. Finally, the antiproliferative activities of the best candidates were evaluated against SH-SY5Y and K562 cell lines. Compound 3 b [2-(4-{2-methyl-6-[(5-phenylthiazol-2-yl)amino]pyrimidin-4-yl}piperazin-1-yl)ethanol] was found to be the most active inhibitor. After reading the article, we found that the author used 2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol(cas: 127116-19-2Recommanded Product: 127116-19-2)

2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol(cas: 127116-19-2) belongs to piperazines. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines.Recommanded Product: 127116-19-2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics