Category: 122833-04-9piperazines

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Z-rnethoxy4–(4-rnethyipiperazin- 1 -yl)aniline (10 g, 452 nunol) in toluene (230 mL) was added Di-tert-butyi dicarbonate (9.87 g, 45.2 mmol). The reaction mixture was stirred at 120 C for 6 hrs and concentrated under reduced pressure. The residue was purified by cohmm chromatography on silica gel (3:97 to 10:90, ammonia solution 7.0 N in methaiiolIdichioromethane) to afford title compound (12.5 g, 86% yield). Rt = 3.23 mm;?H NMR 600 MHz (DMSO-d6) d 7.62 (s, IH), 7.31 (/nc IH), 6.52 (d, .J 2.4 Hz, 1H), 6.38 (dci, J= 2.4 Hz, J= L0 Hz, 1H), 3.72 (s, 3H), 3.04 (in, 4H), 2.39 (in, 4H), 2.17 (s, 3H), 1.38 (r, 9H); MS ni/z: 321.99 [M+ii,., 122833-04-9

122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael; CHOI, Hwan Geun; TAN, Li; WO2015/6492; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

A mixture of IV-II-l-c (28 mg, 0.1 mmol), 2-methoxy-4-(4-methylpiperazin-l- yl)benzenamine (22 mg, 0.1 mmol), X-Phos (4.3 mg), Pd2(dba)3 (5.5 mg) and K2CO3 (41.5 mg, 0.3 mmol) in 1.2 mL of t-BuOH was heated at 100 0C in a seal tube for 4 h. Then the reaction was filtered through celite and eluted with dichloromethane. The dichloromethane was removed in vacuo and the resulting crude product was purified by preparative TLC with 3.5 N ammonia methanol solution and dichloromethane (1/25, v/v) to give the title compound IV-I (8 mg). 1H NMR (600 MHz, CDCl3) delta 8.32 (s, IH), 8.18 (d, J= 8.4 Hz, IH), 7.80 (dd, J= 1.8, 7.8 Hz, IH), 7.61 (s, IH), 7.51 (dd, J= 1.8, 7.8 Hz, IH), 7.40-7.34 (m, 2H), 6.54 (dd, J= 1.8, 8.4 Hz, IH), 6.52 (d, J= 1.8 Hz, IH), 3.85 (s, 3H), 3.55 (s, 3H), 3.23 (s, br, 4H), 2.69 (s, br, 4H), 2.43 (s, 3H). MS (ESI) m/z 463 (M+H)+.

122833-04-9, As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.

Reference£º
Patent; DANA FARBER CANCER INSTITUTE; GRAY, Nathanael, S.; DENG, Xianming; KWIATKOWSKI, Nicholas, Paul; WO2010/80712; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

General procedure: To the solution of 7 (0.54 g, 1.5 mmol) in isopropanol (8 mL) wasadded 10a-d (0.31 g, 1.5 mmol) and p-Toluenesulfonic acid (0.26 g,1.5 mmol). The resulting solution was stirred at 95 C for 6 h. When thecompletion of the reaction, the reaction mixture was quenched withwater (8 mL) and adjusted pH to 8 with sodium bicarbonate. Then themixture was extracted with ethyl acetate (8 mL) for 3 times and thecombined organic layers were washed with water, brine, dried overNa2SO4 and the solvent was evaporated under reduced pressure. Afterpurifying through column chromatography using dichloromethane/methanol as an eluent, the target products 11a-d were obtained in satisfactoryyields.

122833-04-9, 122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Gong, Ping; Guo, Ming; Liu, Sicong; Miao, Xiuqi; Xing, Lingyun; Yin, Shiliang; Zhai, Xin; Zhang, Dajun; Zhang, Hong; Bioorganic Chemistry; vol. 94; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

EXAMPLE 30B 7-chloro-5-(2-methoxy-4-(4-methy lpiperazin- l-yl)pheny lamino)py rido[3.4-i/]py ridazin- 4(3H)-one To a solution of EXAMPLE 7K (120 mg, 0.56 mmol) in dioxane (10 mL) was added EXAMPLE 30A (136 mg, 0.6 ] mmol) and NN-diisopropy lethylamine (724 mg, 5.6 mmol) and the mixture was stirred at 120C in a sealed tube for 16 hours. The mixture was cooled to ambient temperature, poured into water (50 mL) and extracted with ethy l acetate (3 * 50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash chromatography on si lica gel (200-300 mesh) eluting with 50/1 dichlomethane/methanol to give the title compound. MS : 401 (M + IT)., 122833-04-9

The synthetic route of 122833-04-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Exam pe 20olizine-7-carboxamideThis compound was prepared from its corresponding ester, using the same sequence of reactions as described for Exampe I using ntermediate F as starting material. The esterwas subsequently reacted with 2,6-diethylanihne according to procedures described in Examp?e 1. Purification was performed using preparative HPLC to afford the tifle compound (13.5 mg, 23.2%). Data: LCMS (C) Rt:12.686 mm; m/z 566.4 (M+H)., 122833-04-9

As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.

Reference£º
Patent; NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.; DE MAN, Adrianus Petrus Antonius; BUIJSMAN, Rogier Christian; STERRENBURG, Jan Gerard; UITDEHAAG, Joost Cornelis Marinus; DE WIT, Joeri Johannes Petrus; ZAMAN, Guido Jenny Rudolf; WO2015/155042; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To n-butanol (2 mL) was added compound 4A-3 (30 mg, 0.135 mmol) and compound 5A-1 (47 mg, 0.135 mmol), and then p-toluenesulfonic acid (23.3 mg, 0.135mmol) was added under stirring. The mixture was heated to 100C and stirred for 5 hours. After TLC indicated the reaction was completed, the reaction mixture was concentrated under reduced pressure to give a crude product, which was further purified and isolated by column chromatography to obtain an off-white solid product, compound I-13 (56 mg, yield 77.8%). 1H NMR (400 MHz, cd3od) delta 8.49 (d, J=8.4 Hz, 1H), 8.07 (s, 1H), 7.86 (dd, J=8.0, 1.3 Hz, 1H), 7.67 (d, J=8.7 Hz, 1H), 7.60 (dd, J=11.5, 4.3 Hz, 1H), 7.30 (t, J=7.6 Hz, 1H), 6.67 (s, 1H), 6.49 (dd, J=8.7, 2.1 Hz, 1H), 3.84 (s, 3H), 3.29-3.20 (m, 4H), 2.97-

122833-04-9, 122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Humanwell Healthcare (Group) Co., Ltd.; WANG, Xuehai; XU, Yong; SHENG, Xijun; ZHANG, Xiaolin; XIA, Hangui; YANG, Zhongwen; YUE, Yang; HUANG, Lu; XIAO, Qiang; (80 pag.)EP3372594; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To n-butanol (2 mL) was added compound 4A-3 (30 mg, 0.135 mmol) and compound 5A-1 (47 mg, 0.135 mmol), and then p-toluenesulfonic acid (23.3 mg, 0.135mmol) was added under stirring. The mixture was heated to 100C and stirred for 5 hours. After TLC indicated the reaction was completed, the reaction mixture was concentrated under reduced pressure to give a crude product, which was further purified and isolated by column chromatography to obtain an off-white solid product, compound I-13 (56 mg, yield 77.8%). 1H NMR (400 MHz, cd3od) delta 8.49 (d, J=8.4 Hz, 1H), 8.07 (s, 1H), 7.86 (dd, J=8.0, 1.3 Hz, 1H), 7.67 (d, J=8.7 Hz, 1H), 7.60 (dd, J=11.5, 4.3 Hz, 1H), 7.30 (t, J=7.6 Hz, 1H), 6.67 (s, 1H), 6.49 (dd, J=8.7, 2.1 Hz, 1H), 3.84 (s, 3H), 3.29-3.20 (m, 4H), 2.97-

122833-04-9, 122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Humanwell Healthcare (Group) Co., Ltd.; WANG, Xuehai; XU, Yong; SHENG, Xijun; ZHANG, Xiaolin; XIA, Hangui; YANG, Zhongwen; YUE, Yang; HUANG, Lu; XIAO, Qiang; (80 pag.)EP3372594; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics