Category: 1214196-85-6

Analyzing the synthesis route of 1214196-85-6

1214196-85-6, The synthetic route of 1214196-85-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1214196-85-6,1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 1 g rac-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (9, 4.3 mmoles) in 20 mL of anhydrous N,N-dimethylformamide was added 1.7g (12.3 mmoles) of granular potassium carbonate. The slurry wasstirred for 1 hour, and then 1.3 mL (11 mmoles) of benzyl bromide was added and the mixture stirred for an additional 40 hours at room temperature. The reaction mixture was then diluted with water and extracted with ethyl ether. The organic layer was separated and washed with brine (NaCl(aq.)) solution twice. The organic layer was then dried over anhydrous sodium sulfate. Filtration, solvent removal and column chromatography (Hexanes:Ethylacetate gradient) gave 1.49 g of a clear viscous oil (83% yield), which solidified upon standing.

1214196-85-6, The synthetic route of 1214196-85-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Huanyu; Prosser, Anthony R.; Liotta, Dennis C.; Wilson, Lawrence J.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 21; (2015); p. 4950 – 4955;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Downstream synthetic route of 1214196-85-6

As the paragraph descriping shows that 1214196-85-6 is playing an increasingly important role.

1214196-85-6, 1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a precooled (0 C) solution of 1-Boc-piperazine-2-carboxylic acid (500. mg, 2.17 mmol) in 1,4-dioxane (11 mL) under N2 atmosphere was added 1 M aq. NaOH until pH 11 achieved. To the resulting mixture was then added dropwise benzyl chloroformate (0.31 mL, 2.17 mmol) followed by additional 1 M aq. NaOH to maintain pH 11. The resulting mixture was allowed to warm to room temperature and stirred for 3 h, then cooled to 0 C before addition of benzyl chloroformate (0.31 mL, 2.17 mmol) and 1 M aq. NaOH to maintain pH 11. The resulting mixture was allowed to warm to room temperature and stirred for 28 h, then cooled to 0 C and acidified slowly with 1 M aq. HCl to pH 2. The aqueous layer was diluted with EtOAc and the layers were separated then the aqueous phase was extracted with EtOAc (3x). The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo to afford the product, which was carried forward.

As the paragraph descriping shows that 1214196-85-6 is playing an increasingly important role.

Reference£º
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; VAL-CHUM, LIMITED PARTNERSHIP; GRENIER, Melissa Carey; SMITH, Amos B., III; FINZI, Andres; DING, Shilei; CHAPLEAU, Jean-Philippe; (240 pag.)WO2020/28482; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics