Category: 115619-01-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.

A mixture of 5 (0.11g, 0.56mmol), DIPEA (0.10ml, 0.56mmol) and acetonitrile (3ml) was mixed with the 86 (0.10g, 0.56mmol) and then stirred at room temperature for overnight. The reaction was quenched by saturated NaHCO3 (aq.) and the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (dichloromethane: methanol = 15: 1, Rf = 0.18) to afford 90 (0.06g, 30.80%) as a brown solid. 1H-NMR (300MHz, CDCl3): delta 1.15 (t, J= 7.2 Hz, 3H), 2.51 (q, J= 7.2 Hz, 2H), 2.64 (s, 4H), 3.01 (d, J= 7.2 Hz, 3H), 3.22 (t, J= 5.4 Hz, 4H), 5.30 (br, 1H), 5.74 (br, 1H), 6.88-6.94 (m, 2H), 7.11 (s, 1H), 7.35 (d, J= 9.0 Hz, 1H), 7.37-7.48 (s, 1H)., 115619-01-7

The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example No. 125Preparation of N- (4- (4-ethylpiperazin-l-yl) phenyl) -5-(imidazo [1, 2-a] pyridin-2-yl) -lH-pyrazolo [4, 3-d] pyrimidin-7- amine7-chloro-5- (imidazo [1, 2-a] pyridin-2-yl) -2- (4 -methoxybenzyl) – 2H-pyrazolo [4 , 3-d] pyrimidine (0.16 mmol) and 4- (4- ethylpiperazin-l-yl) aniline (0.3 mmol 2 eq.,) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HC1 in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 1 0C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 439.2607 g/mol HPLC-MS: analytical method Crt: 1.787 min – found mass: 440 (m/z+H)

115619-01-7, The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; TRAUBE, Nadine; WO2012/143144; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(5-Chloro-1-methyl-1H-pyrrolo[2,3-c]pyridin-2-yl)(2,6-difluoro-3,5-dimethoxyphenyl)methanol (1000 mg, 2.8 mmol), 4-(4-ethylpiperazin-1-yl)phenylamine (900 mg, 3.6 mmol), Pd2 (dba) 3 (540 mg,0.6 mmol), XantpHos (700 mg, 1.2 mmol), Cs2CO3 (2.0 g, 6 mmol) and toluene (15 ml) were mixed and stirred overnight under 110 C, Ar. The reaction solution was directly dried by column chromatography (dichloromethane:methanol = 97:3) to give compound (2,6-difluoro-3,5-dimethoxyphenyl) (5-((4-(4-) Ethyl piperazin-1-yl)phenyl)amino)-1-methyl-1H-pyrrolo[2,3-c]Pyridin-2-yl)methanone 1.1 g, yield 75%.

115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference：
Patent; Shanghai Xin Qibo Biological Technology Co., Ltd.; Wang Zhaoyin; Ma Jianbin; (39 pag.)CN110092798; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(5-Chloro-1-methyl-1H-pyrrolo[2,3-c]pyridin-2-yl)(2,6-difluoro-3,5-dimethoxyphenyl)methanol (1000 mg, 2.8 mmol), 4-(4-ethylpiperazin-1-yl)phenylamine (900 mg, 3.6 mmol), Pd2 (dba) 3 (540 mg,0.6 mmol), XantpHos (700 mg, 1.2 mmol), Cs2CO3 (2.0 g, 6 mmol) and toluene (15 ml) were mixed and stirred overnight under 110 C, Ar. The reaction solution was directly dried by column chromatography (dichloromethane:methanol = 97:3) to give compound (2,6-difluoro-3,5-dimethoxyphenyl) (5-((4-(4-) Ethyl piperazin-1-yl)phenyl)amino)-1-methyl-1H-pyrrolo[2,3-c]Pyridin-2-yl)methanone 1.1 g, yield 75%.

115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference：
Patent; Shanghai Xin Qibo Biological Technology Co., Ltd.; Wang Zhaoyin; Ma Jianbin; (39 pag.)CN110092798; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.

(5-Chlorofuro[2,3-c]pyridin-2-yl)(2,6-difluoro-3,5-dimethoxyphenyl)methanone (2 g, 5.65 mmol), 4-( 4-ethylpiperazin-1-yl)aniline (1.36 g, 6.78 mmol), cesium carbonate (2.76 g, 5.65 mmol), XantpHOS (1.3 g, 2.26 mmol) and Pd2dba3 (1 g, 1.1 mmol) were added to 30 ml in order. In toluene.Argon was replaced 3-5 times and heated to 110 C (oil bath) for overnight reaction.The reaction was complete by TLC.The mixture was cooled to rt, filtered, and the filter cake was washed with EA, and the filtrate was evaporated to dryness and purified by column (MeOH: DCM = 0-100: 1-70:1) to give solid (2,6-difluoro-3,5-dimethyl Oxyphenyl)(5-((4-(4-ethylpiperazin-1-yl)-2-nitrophenyl)amino)furo[2,3-c]pyridin-2-yl)methanone (2.5g, 79%)., 115619-01-7

As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference：
Patent; Shanghai Xin Qibo Biological Technology Co., Ltd.; Wang Zhaoyin; Ma Jianbin; (39 pag.)CN110092798; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1 equiv of piperazinyl amine was dissolved in pyridine (20 ml/g)and stirred at 0 C under inert atmosphere. 1.2 equiv of cinnamoylchloride derivative was dissolved in dry DCM (10 ml/g) and addeddropwise to above stirred solution at 0 C. The reaction mixturewasstirred for 3 h and was monitored by TLC. After completion of thereaction, the reaction mixturewas diluted withwater (20 ml/g) andethyl acetate (30 ml/g) followed by 2 N HCl to make it acidic. Theprecipitate came out which was filtered as yellow solid and furtherwashed with 2 N HCl and then water. The precipitate was suspendedin saturated bicarbonate solution and stirred vigorously toremove acid impurities. The crude compound was purified eitherby column chromatography or by recrystallization from ethyl acetateand hexane., 115619-01-7

As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference：
Article; Patel, Kavitkumar N.; Telvekar, Vikas N.; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 43 – 56;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5 (0.10g, 0.48mmol), DIPEA (0.08ml, 0.48mmol) and EtOH (5ml) was mixed with the 85 (0.07g, 0.48mmol) and refluxed for 2.5hrs. The reaction was quenched by saturated NaHCO3 (aq.) and the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (dichloromethane: methanol = 9: 1, Rf = 0.28) to afford 89 (0.05g, 33.24%) as a pale yellow solid. 1H-NMR (300MHz, CDCl3): delta 1.13 (t, J= 7.2 Hz, 3H), 2.46 (q, J= 7.2 Hz, 2H), 2.62 (t, J= 5.1 Hz, 4H), 2.98 (d, J= 5.1 Hz, 3H), 3.19 (t, J= 5.1 Hz, 4H), 5.17-5.29 (m, 1H), 5.55 (br, 1H), 6.91 (d, J= 8.7 Hz, 2H), 7.37 (d, J= 8.1 Hz, 1H), 7.46 (s, 1H), 8.20 (d, J= 44.7 Hz, 1H)., 115619-01-7

The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5 (0.10g, 0.48mmol), DIPEA (0.08ml, 0.48mmol) and EtOH (5ml) was mixed with the 85 (0.07g, 0.48mmol) and refluxed for 2.5hrs. The reaction was quenched by saturated NaHCO3 (aq.) and the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (dichloromethane: methanol = 9: 1, Rf = 0.28) to afford 89 (0.05g, 33.24%) as a pale yellow solid. 1H-NMR (300MHz, CDCl3): delta 1.13 (t, J= 7.2 Hz, 3H), 2.46 (q, J= 7.2 Hz, 2H), 2.62 (t, J= 5.1 Hz, 4H), 2.98 (d, J= 5.1 Hz, 3H), 3.19 (t, J= 5.1 Hz, 4H), 5.17-5.29 (m, 1H), 5.55 (br, 1H), 6.91 (d, J= 8.7 Hz, 2H), 7.37 (d, J= 8.1 Hz, 1H), 7.46 (s, 1H), 8.20 (d, J= 44.7 Hz, 1H)., 115619-01-7

The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

48.3 1-(2,4-Dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-3-[4-(4-ethylpiperazin-1-yl)-phenylamino]-5-iodo-1,3-dihydroindol-2-one4-(4-Ethylpiperazin-1-yl)phenylamine (44 mg, 0.21 mmol) was added to a solution of 3-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-5-iodo-1,3-dihydroindol-2-one (110 mg, 0.18 mmol) in dichloromethane (15 ml). The reaction mixture was agitated in a Biotage microwave vial at 120 C. for 4 hours. The reaction mixture was concentrated under reduced pressure. Purification by chromatography (silica gel, 0-8% methanol in dichloromethane) resulted in 16 mg of the title compound (11% yield).ESI-MS: 784.20 [m+H]+ 1H-NMR (500 MHz, d6-DMSO): delta [ppm] 8.15 (m, 1H); 8.05 (d, 1H); 7.85 (d, 1H); 7.75 (d, 1H); 7.50 (d, 1H); 7.30 (s, 1H), 7.10 (dd, 1H); 6.70 (d, 1H); 6.65 (s, 1H); 6.45 (d, 2H); 6.40 (d, 2H); 4.05 (m, 2H); 3.85 (s, 3H); 3.55 (s, 3H); 2.95 (bs, 4H); 2.45 (bs, 4H); 2.35 (m, 2H); 1.00 (t, 3H); 0.90 (t, 3H)., 115619-01-7

As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference：
Patent; Abbott GmbH & Co. KG; US2011/105454; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.

115619-01-7, A mixture of 5 (0.49g, 2.39mmol), H2O (0.75ml) and AcOH (3ml) was mixed with the 83 (0.15g, 3.13mmol) and refiuxed for overnight. The reaction was quenched by saturated NaHCO3 (aq.) and the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (dichloromethane: methanol = 9: 1, Rf = 0.25) to afford 87 (0.60g, 80.20%) as a pale orange solid. 1H-NMR (300MHz, CDCl3): delta 1.16 (t, J= 7.2 Hz, 3H), 2.48 (q, J= 7.2 Hz, 2H), 2.64 (t, J= 5.1 Hz, 4H), 2.81 (d, J= 5.4 Hz, 3H), 3.22 (t, J= 5.1 Hz, 4H), 4.86 (s, 1H), 5.54 (s, 1H), 6.69 (s, 1H), 6.95 (d, J= 9.0 Hz, 2H), 7.18 (d, J= 8.7 Hz, 2H), 8.14 (s, 1H).

115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics