Category: 109-01-3

Related Products of 109-01-3In 2020 ,《Synthesis, biological evaluation and kinase profiling of novel S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole derivatives as cytotoxic agents with apoptosis-inducing activity》 was published in Journal of Molecular Structure. The article was written by Abdelazeem, Ahmed H.; Alqahtani, Alaa M.; Omar, Hany A.; Bukhari, Syed Nasir Abbas; Gouda, Ahmed M.. The article contains the following contents:

A novel set of S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazoles I [R = (adamantan-1-yl)aminyl, pyrrolidin-1-ylmethyl, (hexylamino)methyl, [(1,3-benzothiazol-2-yl)amino]methyl, etc.] was synthesized. Cytotoxicity of these compounds was evaluated against three cancer cell lines of different origins, Hep3B, A549, and MCF-7. Three of these compounds I [R = (4-chlorophenyl)aminyl, piperidin-1-ylmethyl, [(adamantan-1-yl)amino]methyl] were screened by NCI for growth inhibitory activities against 60 cancer cell lines. The results revealed significant cytotoxic activities for compounds I [R = pyrrolidin-1-ylmethyl, (hexylamino)methyl, [(1,3-benzothiazol-2-yl)amino]methyl, etc.]. Among these derivatives, compounds I [R = azepan-1-ylmethyl, (4-methylpiperazin-1-yl)methyl (A), (hexylamino)methyl (B), [(adamantan-1-yl)amino]methyl (C), [(1,3-benzothiazol-2-yl)amino]methyl (D)] exhibited the highest cytotoxicity against the selected cancer cell lines with IC50 values between 3.17 and 14.18μM. The structure-activity relationship of compounds I [R = pyrrolidin-1-ylmethyl, (hexylamino)methyl, [(1,3-benzothiazol-2-yl)amino]methyl, etc.] indicated favorable cytotoxic results on the expansion of the cyclic amine and the substitution with aminothiazole moiety. A mechanistic study revealed the activation of caspase-3/7 in A549 cells on treatment with compounds A-D at 5-20μM. Moreover, the results of flow cytometric anal. suggested that compound D efficiently induced apoptosis in a dose-dependent manner. Compounds A, B, D also exhibited a weak to moderate inhibition of multiple kinases where compound D was the most active in inhibiting the activity of CDK2/Cyclin A1 (IC50 = 4.65μM). The current work provided a novel set of compounds I with cytotoxic, kinase inhibition, and apoptosis-inducing activities, which can serve as a lead for further optimization. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Related Products of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Related Products of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 109-01-3In 2019 ,《Solvent-free syntheses of two pcu topological indium phosphite-oxalates with a novel butterfly motif and proton conductivity》 was published in Microporous and Mesoporous Materials. The article was written by Jiang, Yansong; Song, Jianshu; Xiu, Zhijia; Huang, Liangliang; Gao, Fan; Jiao, Shufei; Bi, Yanfeng. The article contains the following contents:

Under solvent-free conditions, two new 3D open-framework indium phosphite-oxalates In5(HPO3)6(H1.5PO3)2(C2O4)2·(H2A)2, where A = C5N2H12 (compound 1) and C6N2H14 (compound 2), are synthesized by using 1-methylpiperazine and 1-ethylpiperazine as the structure-directing agent, resp. Single crystal x-ray diffraction reveals that these two compounds have the analog inorganic framework structures, which may be viewed as the assembly of butterfly motifs and [C2O2-4] groups. Interestingly, the butterfly motif is firstly reported in metal phosphite/phosphite-oxalate. By regarding the butterfly motifs as topol. equivalent 4-connected nodes and thus framework can be simplified into a uninodal pcu network with point symbol of (412, 63). 1 And 2 are also characterized by powder x-ray diffraction, IR spectroscopy, SEM, TGA, ICP-AES and elemental analyses. In addition, proton conduction was investigated by alternating-current impedance anal. and the results demonstrate that both compounds show high proton-conductive properties with the conductivity of 3.4 × 10-3 S cm-1 and 2.1 × 10-3 S cm-1 at 75° and 98% RH, resp. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Related Products of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Related Products of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Product Details of 109-01-3In 2021 ,《Synthesis and characterization of new potent TLR7 antagonists based on analysis of the binding mode using biomolecular simulations》 appeared in European Journal of Medicinal Chemistry. The author of the article were Pal, Sourav; Paul, Barnali; Bandopadhyay, Purbita; Preethy, Nagothy; Sarkar, Dipika; Rahaman, Oindrila; Goon, Sunny; Roy, Swarnali; Ganguly, Dipyaman; Talukdar, Arindam. The article conveys some information:

Aberrant activation of the endosomal Toll-like receptor 7 (TLR7) has been implicated in myriad autoimmune diseases and is an established therapeutic target in such conditions. Development of diverse TLR7 antagonists is mainly accomplished through random screening. To correlate human TLR7 (hTLR7) antagonistic activity with the structural features in different chemotypes, a hypothetical binding model is derived based on mol. docking anal. along with mol. dynamics (MD) simulations study. The binding hypothesis revealed different pockets, grooves and a central cavity where ligand-receptor interaction with specific residues through hydrophobic and hydrogen bond interactions take place, which correlate with TLR7 antagonistic activity, thus paving the way for rational design using varied chemotypes. Based on the structural insight thus gained, TLR7 antagonists with quinazoline, e.g., I were designed to understand the effect of engagement of these pockets as well as boundaries of the chem. space associated with them. The newly synthesized most potent hTLR7 antagonist, e.g., I, showed IC50 value of 1.03 ± 0.05μM and was validated by performing primary assay in human plasmacytoid dendritic cells (pDC) (ICpDC50: 1.42μM). The biol. validation of the synthesized mols. was performed in TLR7-reporter HEK293 cells as well as in human plasmacytoid dendritic cells (pDCs). This study provides a rational design approach, thus facilitating further development of novel small mol. hTLR7 antagonists based on different chem. scaffolds. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3Product Details of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Product Details of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Category: piperazinesIn 2020 ,《Synthesis and Aminoalkylation of N-Propargyl Triterpene Aldimines》 appeared in Russian Journal of Organic Chemistry. The author of the article were Petrova, A. V.; Khusnutdinova, E. F.; Mustafin, A. G.; Kazakova, O. B.. The article conveys some information:

Mannich reaction of N-propargyl triterpene aldimines obtained from betulonic and oleanonic aldehydes gave new aminoalkyl derivatives containing an N-methylpiperazine fragment. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Category: piperazines)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Melin, Lea; Calosing, Cyrus; Kharenko, Olesya A.; Hansen, Henrik C.; Gagnon, Alexandre published an article in 2021. The article was titled 《Synthesis of NVS-BPTF-1 and evaluation of its biological activity》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Category: piperazines The information in the text is summarized as follows:

BPTF (bromodomain and PHD finger containing transcription factor) is a multidomain protein that plays essential roles in transcriptional regulation, T-cell homeostasis and stem cell pluripotency. As part of the chromatin remodeling complex hNURF (nucleosome remodeling factor), BPTF epigenetic reader subunits are particularly important for BPTF cellular function. Thus, in this paper, the synthesis of NVS-BPTF-1, I, a previously reported highly potent and selective BPTF-bromodomain inhibitor, is reported. Evaluation of the impact of the inhibition of BPTF-bromodomain using NVS-BPTF-1 on selected proteins involved in the antigen processing pathway revealed that exclusively targeting BPTF-bromodomain was insufficient to observe an increase of PSMB8, PSMB9, TAP1, and TAP2 proteins. The results came from multiple reactions, including the reaction of 1-Methylpiperazine(cas: 109-01-3Category: piperazines)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In 2019,Chemistry & Biology Interface included an article by Ismail, Pathan Sultan; Khan, Irfan; Kumar, Vivek; Verma, Ved Prakash; Shukla, Monika; Dhasmana, Anupam; Pandey, Shashi; Singh, Girdhar Pal; Khan, Shahnawaz; Singh, Jaybir. Recommanded Product: 1-Methylpiperazine. The article was titled 《Synthesis and biological evaluation of 2,4-diaminopyrimidine-5-carbonitrile and N-(2-amino-5-cyanopyrimidin-4-yl)benzamide derivatives as EGFR inhibitors》. The information in the text is summarized as follows:

A series of 2,4-diaminopyrimidine-5-carbonitriles and N-(2-amino-5-cyanopyrimidin-4-yl)benzamides I and II [R = 1-piperidyl, 1-morpholinyl, 4-methylpiperazin-1-yl, 4-benzylpiperazin-1-yl, 4-(2-methoxyphenyl)piperazin-1-yl] were synthesized and their chem. structures were confirmed by 1H, 13C NMR and mass spectral data. Anticancer activity of all the synthesized compounds I and II were evaluated for in-vitro cytotoxic activity against a panel of four human cancer cell lines i.e., human breast (MCF-7), cervical cancer (C33A), oral (KB) and prostrate (DU-145). All the examined compounds, I and II demonstrated potent to moderate anticancer activity. Among all the synthesized compounds, I [ R = 1-(2-methoxyphenyl)piperazinyl] and II [R1 = 1-(2-methoxyphenyl)piperazinyl] exhibited more potent activity. Docking studies for I [ R = 1-(2-methoxyphenyl)piperazinyl] and II [R1 = 1-(2-methoxyphenyl)piperazinyl] into EGFR active site was carried out to investigate their potential binding modes. Therefore, compounds I [ R = 1-(2-methoxyphenyl)piperazinyl] and II [R1 = 1-(2-methoxyphenyl)piperazinyl] was considered as fascinating candidates for further expansion of more potent anticancer agents. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In 2019,Rasayan Journal of Chemistry included an article by Venkatasubramanian, H.; Sha, Sarojkumar; Hemalatha, S.; Easwaramoorthy, D.. Recommanded Product: 1-Methylpiperazine. The article was titled 《Synthesis, characterisation and antimicrobial activity of new nicotinamide-thiazole derivatives》. The information in the text is summarized as follows:

This work selected the already known mild active mols. such as Nicotinamide and Thiazole I [R = cyclopropyl, cyclobutyl, Ph, etc.] to enhance the activity against the disease-causing pathogens. Using peptide coupling reagent EDCI, nine compounds I were prepared and characterized by 1H NMR, Mass spectroscopy. The characterized compounds I were evaluated in-vitro antibacterial and antifungal activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, Candida albicans by broth dilution method and zone of inhibition measured in millimeter. All the derivatives I showed good to moderate activity. Out of nine compounds I [R = thiomorpholinyl] showed better zone of inhibition between 27 mm and 34 mm. The outcomes of the result revealed that the diamide bond acts as an important pharmacophore and exposed the good inhibition behavior. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Bouassiria, M.; Laabaissi, T.; Benhiba, F.; El Faydy, M.; Fakhry, H.; Oudda, H.; Assouag, M.; Touir, R.; Guenbour, A.; Lakhrissi, B.; Warad, I.; Zarrouk, A. published an article in 2021. The article was titled 《Corrosion inhibition effect of 5-(4-methylpiperazine)-methylquinoline-8-ol on carbon steel in molar acid medium》, and you may find the article in Inorganic Chemistry Communications.Application In Synthesis of 1-Methylpiperazine The information in the text is summarized as follows:

The present study provides a new application of the 5-(4-methylpiperazinyl)-methylquinolin-8-ol (MPMQ) as an inhibitor for corrosion of carbon steel (CS) in acidic media (1 M HCl). The inhibition performance of MPMQ was evaluated using various methods including electrochem. impedance spectroscopy (EIS), potentiodynamic polarization (PDP), surface morphol. anal. (SEM), quantum chem. computations (DFT), and Monte Carlo simulations (MC). The obtained results, indicating that the compound as a mixed-type inhibitor significantly reduced the corrosion rate of CS due to the formation of a stable protective film on the metal surface. As confirmed by EIS, SEM and theor. studies, chem. adsorbed MPMQ mol. is a better corrosion inhibitor with higher corrosion performance of about 95% at room temperature Langmuir isotherm model is the most acceptable one to describe the MPMQ mols. adsorption on the CS-surface. Finally, the exptl. data correlated well with the theor. study. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Application In Synthesis of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Application In Synthesis of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 109-01-3In 2020 ,《Synthesis, biological evaluation and kinase profiling of novel S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole derivatives as cytotoxic agents with apoptosis-inducing activity》 was published in Journal of Molecular Structure. The article was written by Abdelazeem, Ahmed H.; Alqahtani, Alaa M.; Omar, Hany A.; Bukhari, Syed Nasir Abbas; Gouda, Ahmed M.. The article contains the following contents:

A novel set of S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazoles I [R = (adamantan-1-yl)aminyl, pyrrolidin-1-ylmethyl, (hexylamino)methyl, [(1,3-benzothiazol-2-yl)amino]methyl, etc.] was synthesized. Cytotoxicity of these compounds was evaluated against three cancer cell lines of different origins, Hep3B, A549, and MCF-7. Three of these compounds I [R = (4-chlorophenyl)aminyl, piperidin-1-ylmethyl, [(adamantan-1-yl)amino]methyl] were screened by NCI for growth inhibitory activities against 60 cancer cell lines. The results revealed significant cytotoxic activities for compounds I [R = pyrrolidin-1-ylmethyl, (hexylamino)methyl, [(1,3-benzothiazol-2-yl)amino]methyl, etc.]. Among these derivatives, compounds I [R = azepan-1-ylmethyl, (4-methylpiperazin-1-yl)methyl (A), (hexylamino)methyl (B), [(adamantan-1-yl)amino]methyl (C), [(1,3-benzothiazol-2-yl)amino]methyl (D)] exhibited the highest cytotoxicity against the selected cancer cell lines with IC50 values between 3.17 and 14.18μM. The structure-activity relationship of compounds I [R = pyrrolidin-1-ylmethyl, (hexylamino)methyl, [(1,3-benzothiazol-2-yl)amino]methyl, etc.] indicated favorable cytotoxic results on the expansion of the cyclic amine and the substitution with aminothiazole moiety. A mechanistic study revealed the activation of caspase-3/7 in A549 cells on treatment with compounds A-D at 5-20μM. Moreover, the results of flow cytometric anal. suggested that compound D efficiently induced apoptosis in a dose-dependent manner. Compounds A, B, D also exhibited a weak to moderate inhibition of multiple kinases where compound D was the most active in inhibiting the activity of CDK2/Cyclin A1 (IC50 = 4.65μM). The current work provided a novel set of compounds I with cytotoxic, kinase inhibition, and apoptosis-inducing activities, which can serve as a lead for further optimization. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Related Products of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Related Products of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 109-01-3In 2019 ,《Solvent-free syntheses of two pcu topological indium phosphite-oxalates with a novel butterfly motif and proton conductivity》 was published in Microporous and Mesoporous Materials. The article was written by Jiang, Yansong; Song, Jianshu; Xiu, Zhijia; Huang, Liangliang; Gao, Fan; Jiao, Shufei; Bi, Yanfeng. The article contains the following contents:

Under solvent-free conditions, two new 3D open-framework indium phosphite-oxalates In5(HPO3)6(H1.5PO3)2(C2O4)2·(H2A)2, where A = C5N2H12 (compound 1) and C6N2H14 (compound 2), are synthesized by using 1-methylpiperazine and 1-ethylpiperazine as the structure-directing agent, resp. Single crystal x-ray diffraction reveals that these two compounds have the analog inorganic framework structures, which may be viewed as the assembly of butterfly motifs and [C2O2-4] groups. Interestingly, the butterfly motif is firstly reported in metal phosphite/phosphite-oxalate. By regarding the butterfly motifs as topol. equivalent 4-connected nodes and thus framework can be simplified into a uninodal pcu network with point symbol of (412, 63). 1 And 2 are also characterized by powder x-ray diffraction, IR spectroscopy, SEM, TGA, ICP-AES and elemental analyses. In addition, proton conduction was investigated by alternating-current impedance anal. and the results demonstrate that both compounds show high proton-conductive properties with the conductivity of 3.4 × 10-3 S cm-1 and 2.1 × 10-3 S cm-1 at 75° and 98% RH, resp. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Related Products of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Related Products of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics