Category: 109-01-3

Erol, Meryem; Celik, Ismail; Kuyucuklu, Gulcan published an article in 2021. The article was titled 《Synthesis, Molecular Docking, Molecular Dynamics, DFT and Antimicrobial Activity Studies of 5-substituted-2-(p-methylphenyl)benzoxazole Derivatives》, and you may find the article in Journal of Molecular Structure.Product Details of 109-01-3 The information in the text is summarized as follows:

In this study, new 2-(p-methylphenyl)-5-(2-substituted acetamido)benzoxazole derivatives I [X = N, O; R = H, Me, Meo] were synthesized and antimicrobial activities on six bacteria and their twelve drug-resistant isolates and one fungus and its two drug-resistant isolates were investigated by microdilution method. I [X = O; R = Me] against Staphylococcus aureus isolate and I [X = O; R = Me, MeO] against Escherichia coli isolate showed more potent antimicrobial activity with MIC value of 16μg/mL than some of the reference drugs. The compounds’ I interactions on the DNA gyrase enzyme were evaluated by mol. docking and mol. dynamics simulations. Docked compounds I have demonstrated superimposition in the DNA gyrase ATP binding site with similar protein-ligand interactions. With 50 ns duration mol. dynamics simulations, the average RMSD value of the DNA gyrase subunit B protein and I [X = N, O; R = H, Me, Meo] complexes were measured at about 0.15 nm. The ligands-bound DNA gyrase subunit B protein is a little less RMSF value and more stable than the apoprotein form between 45-49 residues in the active site amino acids region. Geometric optimization parameters, HOMO-LUMO orbital energies, and other electronic parameters derived from these energies, MEP, and NBO anal. were performed the DFT/B3LYP theory and 6-311G (d,p) basis set. The ΔE: LUMO-HOMO of the two most active compounds I [X = O; R = Me, MeO] were 4.2928 and 4.3219, resp. The compounds’ I predicted ADME profiles were in line with Lipinski and other limiting rules. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Product Details of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Product Details of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cao, Yue; Zhou, Xiaoying; Luan, Lindong; Zeng, Hongmei; Zou, Guohong; Lin, Zhien published an article in 2021. The article was titled 《Organically templated metal phosphate-oxalates: Solvent-free synthesis, crystal structure, and proton conduction》, and you may find the article in Inorganic Chemistry Communications.COA of Formula: C5H12N2 The information in the text is summarized as follows:

Two new metal phosphate-oxalates, namely, H2api·Mn2(H2PO4)2(C2O4)2 (1) and H2mpip·Sc(H2PO4)2(C2O4)·0.5C2O4·1.5H2O (2), were prepared under solvent-free conditions, where api = 1-(3-aminopropyl)imidazole and mpip = 1-methylpiperazine. Compound 1 has a honeycomb-like structure with 12-ring windows. Compound 2 has a one-dimensional structure with scandium phosphate ladders decorated with oxalate ligands. The proton-conducting behaviors of this compound under 95% relative humidity were investigated. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3COA of Formula: C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..COA of Formula: C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great In Vivo Efficacy in a Mouse Lung Fibrosis Model》 was written by Lei, Hongrui; Guo, Ming; Li, Xiaopeng; Jia, Fang; Li, Changtao; Yang, Yu; Cao, Meng; Jiang, Nan; Ma, Enlong; Zhai, Xin. SDS of cas: 109-01-3 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Autotaxin (ATX) is the dominant catalytic enzyme accounting for the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine (LPC). There is great interest in developing nonacidic ATX inhibitors with a specific binding mode to serve as potential in vivo effective therapeutic tools. Herein, dating from a high-throughput screening (HTS) product Indole-1 (740 nM), a dedicated optimization campaign was implemented through derivatizing the -COOH group to versatile linkers that well-bridged the indole skeleton and the hydrophobic pocket binding groups. Ultimately, it was established that the coexistence of a carbamate linker and -OH-group-containing amines could generally furnish excellent indole-based ATX inhibitors with even below 1 nM in vitro activities. Two optimal entities were advanced to a bleomycin-induced mice pulmonary fibrosis model, which exerted promising efficacy in alleviating the damaged lung texture caused by bleomycin exposure. The novel carbamate-containing indole-based ATX inhibitors with a concrete binding mode may contribute to the identification of potential therapeutic agents to intervene in fibrotic diseases. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3SDS of cas: 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..SDS of cas: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《A Cu (I) catalyzed large scale synthesis of an antipsychotic drug substance Clozapine with new precursor 2-chloro benzoic acid》 was published in Arabian Journal of Chemistry in 2020. These research results belong to Venkat Rao, S.. Category: piperazines The article mentions the following:

Development of an economic and com. manufacturing process for an anti-psychotic drug substance clozapine I with an alternative key starting material (2-chloro benzoic acid) in the place of literature reported key starting material Anthranilic acid. To avoid narcotic key starting materials usage in drug substances the author invented a com. available raw material 2-chlorobenzoic acid, which reacts with another key starting material 4-chloro-1,2-diamino benzene. This reaction proceeded through Ullman reaction to produce multi scale level Clozapine which quality meets the ICH requirements.1-Methylpiperazine(cas: 109-01-3Category: piperazines) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《One-pot multicomponent synthesis of novel 3, 4-dihydro-3-methyl-2(1H)-quinazolinone derivatives and their biological evaluation as potential antioxidants, enzyme inhibitors, antimicrobials, cytotoxic and anti-inflammatory agents》 was written by Farooq, Samra; Mazhar, Aqsa; Ihsan-Ul-Haq; Ullah, Naseem. Electric Literature of C5H12N2 And the article was included in Arabian Journal of Chemistry in 2020. The article conveys some information:

A series of 3,4-dihydro-3-methyl-2(1H)-quinazolinones I [R = pyrrolidin-1-yl, 1-piperidyl, morpholino, etc.] with amines and formaldehyde were designed and synthesized by a reflux condensation reaction in the presence of an acid catalyst resulted in N-Mannich bases. Mannich bases I were evaluated pharmacol. for their antioxidant, α-amylase enzyme inhibition, antimicrobial, cell cytotoxicity and anti-inflammatory activities. Most of the compounds I exhibited potent activities against these bioassays. Among them, compounds I [R = 1-piperidyl, N-acetyl-4-hydroxyanilino] showed potent antioxidant activity against DPPH free radical at IC50 of 9.94 ± 0.16μg/mL and 11.68 ± 0.32μg/mL, resp. Compounds I [R = N-phenylanilino, N-acetylanilino, N-acetyl-4-hydroxyanilino] showed significant resulted in TAC and TRP antioxidant assays, comparable to that of ascorbic acid. Compounds I [R = morpholino, pyrrolidin-1-yl] showed potent activity in inhibiting α-amylase enzyme at IC50 of 10.17 ± 0.23μg/mL and 9.48 ± 0.17μg/mL, resp., when compared with acarbose (13.52 ± 0.19μg/mL). Compound I [R = N-phenylanilino] was the most active against Gram-pos. and Gram-neg. bacterial strains, compound I [R = N-acetyl-4-hydroxyanilino] was the most potent against P. aeruginosa inhibited its growth up to 80% (MIC = 11.11μg/mL). Compounds I [R = dipropylamino, 4-methylpiperazin-1-yl, piperazin-1-yl] exhibited significant activity against some fungal strains. Among the thirteen N-Mannich bases I, four were screened out based on the results of brine shrimp lethality assay (LD50) and cell cytotoxicity assay (IC50),determine their anti-cancer potential against Hep-G2 cells. The study was conducted for 24, 48, and 72 h. Compound I [R = diethylamino] showed potent results at IC50 of 6.48μM at 72 h when compared with cisplatin (2.56μM). An in-vitro nitric oxide (NO) assay was performed to shortlist compounds for in-vivo anti-inflammatory assay. Among shortlisted compounds, I [R = N-acetyl-4-hydroxyanilino] exhibited potent anti-inflammatory activity by decreasing the paw thickness to the maximum compared to the standard, acetylsalicylic acid (ASA). The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3Electric Literature of C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Electric Literature of C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The author of 《Synthesis of dithioacetylenic piperazine derivatives》 were Mukanova, M. S.; Sycheva, Ye. S.; Seilkhanov, T. M.; Yu, V. K.. And the article was published in Khimicheskii Zhurnal Kazakhstana in 2019. COA of Formula: C5H12N2 The author mentioned the following in the article:

The conditions for the three-component one-pot synthesis of dithioacetylenic piperazine derivatives was developed. As a result prop-2-yn-1-yl-4-methylpiperazine-1-carbodithioate (73.4%) and prop-2-yn-1-yl-4-diphenylmethylpiperazine-1-carbodithioate (93.6%) were synthesized. Structure of dithioacetylenic piperazine derivatives were established based on IR and NMR(1H and 13C) spectroscopic data. In addition to this study using 1-Methylpiperazine, there are many other studies that have used 1-Methylpiperazine(cas: 109-01-3COA of Formula: C5H12N2) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..COA of Formula: C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 109-01-3In 2020 ,《Efficient Synthesis of Sulfenamides through Mitsunobu-type Coupling Reaction of Thiols with Amines using Dibenzyl Azodicarboxylate》 was published in Asian Journal of Organic Chemistry. The article was written by Ryu, Se Hwan; Ra, Jongmin; Ko, Haye Min. The article contains the following contents:

S-H activation reaction of thiols employing dibenzyl azodicarboxylate (DBAD) had been developed for the preparation of sulfenamides I [R = H; R1 = Et, Bn, cyclopropyl, cyclopentyl, cyclohexyl; RR1 = (CH2)4, (CH2)6, (CH2)2O(CH2)2, etc.; X = O, S]. The dehydrogenation of thiols and amines under these reaction conditions involved the formation of dibenzyl hydrazine-1,2-dicarboxylate, which led to the S-N bond formation reaction. The reaction proceeded efficiently with release of dibenzyl hydrazine-1,2-dicarboxylate and afforded various sulfenamides I in good to excellent yields. In addition to this study using 1-Methylpiperazine, there are many other studies that have used 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 109-01-3) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In 2022,Yamaguchi, Nobuharu; Biniecki, Kristof; Jankowski, Christopher K.; Ciszewski, Lech published an article in Acta Poloniae Pharmaceutica. The title of the article was 《Cardiovascular evaluation of the chemical structure of N-methylpiperazinyl phthalazine analogs》.Product Details of 109-01-3 The author mentioned the following in the article:

The chem. structure of N-methylpiperazinyl phthalazine analogs – KB compounds, having potential cardiovascular effects, were synthesized and its detailed spectral identification is reported. For KB-1, moiety structure, five physiol. cardiovascular tests were performed and the results were discussed. This mol. showed long-lasting antihypertensive properties with similarly long-lasting bradycardia. However, a slight modification of the mol. structure might minimize the cardiac depressant phenomenon, which is a common undesired effect of various antihypertensive drugs on the market. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Product Details of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Product Details of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In 2022,Venkatesh, Rapelly; Shankar, Gauri; Narayanan, Aswathi C.; Modi, Gyan; Sabiah, Shahulhameed; Kandasamy, Jeyakumar published an article in Journal of Organic Chemistry. The title of the article was 《Multicomponent Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer’s Disease》.Product Details of 109-01-3 The author mentioned the following in the article:

Multicomponent synthesis of biol. relevant S-benzyl dithiocarbamates I [Ar = Ph, 2-thienyl, 2-naphthyl, etc.; R = methylamino, 1-pyrrolidinyl, benzylamino, etc.] from para-quinone methides, amines and carbon disulfide were described under catalyst and additive-free conditions. The reactions proceeded at room temperature in a short span of time with excellent yields. One of the synthesized compounds, compound I [Ar = Ph, R = isopropylamino] showed considerable acetylcholinesterase (AChE) inhibitory (51.70 + 5.63% at 20μm) and antioxidant (63.52 ± 1.15 at 20μm) activities. In addition to this study using 1-Methylpiperazine, there are many other studies that have used 1-Methylpiperazine(cas: 109-01-3Product Details of 109-01-3) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Product Details of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

《Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis》 was written by Lu, Guo-Liang; Tong, Amy S. T.; Conole, Daniel; Sutherland, Hamish S.; Choi, Peter J.; Franzblau, Scott G.; Upton, Anna M.; Lotlikar, Manisha U.; Cooper, Christopher B.; Denny, William A.; Palmer, Brian D.. COA of Formula: C5H12N2 And the article was included in Bioorganic & Medicinal Chemistry in 2020. The article conveys some information:

A series of 5,8-disubstituted tetrahydroisoquinolines e.g., 2-((5-(4-chlorophenyl)pyridin-2-yl)methyl)-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline were shown to be effective inhibitors of M. tb in culture and modest inhibitors of M. tb ATP synthase. There was a broad general trend of improved potency with higher lipophilicity. Large substituents (e.g., Bn) at the tetrahydroquinoline 5-position were well-tolerated, while N-methylpiperazine was the preferred 8-substituent. Structure-activity relationships for 7-linked side chains showed that the nature of the 7-linking group was important; -CO- and -COCH2- linkers were less effective than -CH2- or -CONH- ones. This suggests that the positioning of a terminal aromatic ring is important for target binding. Selected compounds showed much faster rates of microsomal clearance than the clin. ATP synthase inhibitor bedaquiline, and modest inhibition of mycobacterial ATP synthase. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpiperazine(cas: 109-01-3COA of Formula: C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..COA of Formula: C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics