Category: 109-01-3

The author of 《Determination of base dissociation constants (Pkb) of mono- and polyamines by pH metric method》 were Ahmad, Mamshad; Masohan, Asha; Sawhney, S. S.. And the article was published in International Journal of Research in Chemistry and Environment in 2019. Application In Synthesis of 1-Methylpiperazine The author mentioned the following in the article:

Dissociation constants of acids and bases (pKa and pKb) are very important criteria to define the strength of acids or bases. In organic chem. acids generally the compounds that contain -COOH group and bases are amines and their derivatives This paper presents the study of pKb of about 20 organic amines. pKb determination is done pH metrically which is a very simple method for this type of study. pKb of some of the reported amines are already determined by various researcher by using different methods. Most of the amines reported in this paper are studied fist time for pKb study. It is found that those amines which are studied for pKb value and available in the literature, give almost same result with presented corresponding values. Some of the amines (bases) are common but most of the amines are uncommon and they are used for a very specific purpose. pKa value is used in many cases to solve connecting problems. These pKb values can be used for research and other purposes. This paper presents the pKa/pKb determination of mono-(one amino group), di-(two amino group), tri-(three amino group) and tetra (four amino groups) amines, which will be a very good work for others for research purposes. The results came from multiple reactions, including the reaction of 1-Methylpiperazine(cas: 109-01-3Application In Synthesis of 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Application In Synthesis of 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C5H12N2In 2020 ,《Solvent free synthesis of three cyclotriphosphazene derivatives containing piperazine substituents using microwave irradiation. Spectral, theoretical, solution and docking studies》 was published in Phosphorus, Sulfur and Silicon and the Related Elements. The article was written by Hakimi, Mohammad; Rezaei, Homeyra; Moeini, Keyvan; Mardani, Zahra; Carpenter-Warren, Cameron. The article contains the following contents:

Three new cyclotriphosphazene-based compounds, 2,2,4,4,6,6-hexakis(4-R-piperazin-1-yl)-1,3,5,2λ5,4λ5,6λ5-cyclotriazatriphosphinine (1-3; R = Me, Et, Ph), were prepared and identified by elemental anal., FT-IR, Raman as well as 1H and 31P NMR spectroscopy. The redox properties of the compounds were investigated by cyclic voltammetry. The predicted structures and charge distribution patterns of the compounds were obtained by DFT calculations and NBO anal. The geometrical parameters in these optimized structures are in good agreement with the average values obtained for analogs from the CSD database. The theor. studies confirm presence of a strong resonance in the cyclotriphosphazene ring. Finally, the ability of the three new derivatives to interact with ten selected biomacromols. (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS, Top II, B-DNA) was investigated by docking calculations and compared with that of doxorubicin. In addition to this study using 1-Methylpiperazine, there are many other studies that have used 1-Methylpiperazine(cas: 109-01-3Synthetic Route of C5H12N2) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Synthetic Route of C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Kesarkar, Dnyanadeo J.; Kashid, Bharat B.; Sukthankar, Sunil S. published an article in 2021. The article was titled 《Facile new alternative method for the synthesis of 1-(3-methyl-1-phenyl-1H-pyrazole-5-yl)piperazine from 1-methylpiperazine and 1-benzylpiperazine》, and you may find the article in Organic Preparations and Procedures International.Recommanded Product: 1-Methylpiperazine The information in the text is summarized as follows:

An alternative method for the synthesis of 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine I from 1-methylpiperazine and 1-benzylpiperazine was described. This method avoided the use of labile protecting groups and thus had the potential to improve the impurity profile of key intermediate I. The method used com. available reactants and did not require the use of highly unstable, expensive or hazardous reagents. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 1-Methylpiperazine)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 1-Methylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C5H12N2In 2020 ,《Design and optimization of quinazoline derivatives: new non-nucleoside inhibitors of bovine viral diarrhea virus》 appeared in Frontiers in Chemistry (Lausanne, Switzerland). The author of the article were Fernandez, Gabriela A.; Castro, Eliana F.; Rosas, Rocio A.; Fidalgo, Daniela M.; Adler, Natalia S.; Battini, Leandro; Espana de Marco, Maria J.; Fabiani, Matias; Bruno, Ana M.; Bollini, Mariela; Cavallaro, Lucia V.. The article conveys some information:

In a previous work, potential mols. that dock into an allosteric binding pocket of BVDV RdRp via a structure-based virtual screening approach was identified. One of them, N-(2-morpholinoethyl)-2-phenylquinazolin-4-amine I [R2 = Ph; R4 = 2-morpholinoethylamino; R7 = H] [50% effective concentration (EC50) = 9.7 ± 0.5μM], was selected to perform different chem. modifications. Among synthesized derivatives I [R2 = H, Ph, 4-MeC6H4, etc.; R4 = 4-methylpiperazin-1-yl, HN(CH2)5CH3, 4-methoxyanilino, etc.; R7 = H, Cl], compound I [R2 = H, Ph, 4-(Me)2NC6H4; R4 = 4-methylpiperazin-1-yl, 3-(dimethylamino)propylamino, 4-(2-hydroxyethyl)piperazin-1-yl, (2-morpholinoethylamino), 2-(1-piperidyl)ethylamino, 2-(1-piperidyl)ethylamino, (2,2,6,6-tetramethyl-4-piperidyl)amino, ; R7 = H, Cl] of them showed considerable antiviral activity. Mol. modeling of the most active compounds I [R2 = H, Ph, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-(Me)2NC6H4; R4 = 4-methylpiperazin-1-yl, 3-(dimethylamino)propylamino, 4-(2-hydroxyethyl)piperazin-1-yl, 2-morpholinoethylamino, 2-(1-piperidyl)ethylamino, (2,2,6,6-tetramethyl-4-piperidyl)amino; R7 = H, Cl] showed that they bind to a pocket located in the fingers and thumb domains in BVDV RdRp, which was different than that identified for other non-nucleoside inhibitors (NNIs) such as thiosemicarbazone (TSC). Compound 2-[4-(2-phenylquinazolin-4-yl)piperazin-1-yl]ethanol I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] ( EC50 = 1.7 ± 0.4μM) was selected for further anal. Compound I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] was found to inhibit the in vitro replication of TSC-resistant BVDV variants, which carry the N264D mutation in the RdRp. In addition, I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] presented adequate solubility in different media and a high-stability profile in murine and bovine plasma. In the experiment, the researchers used 1-Methylpiperazine(cas: 109-01-3Synthetic Route of C5H12N2)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Synthetic Route of C5H12N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Zak, Agnieszka; Lemaire, Lucas; Chalon, Sylvie; Chicheri, Gabrielle; Marzag, Hamid; Bodard, Sylvie; Serriere, Sophie; Routier, Sylvain; Buron, Frederic; Vercouillie, Johnny published an article in 2021. The article was titled 《[18F]-labeled positron emission tomography ligand for the histamine H4 receptor》, and you may find the article in Journal of Labelled Compounds and Radiopharmaceuticals.Application of 109-01-3 The information in the text is summarized as follows:

We synthesized 5-[18F]-fluoro-1H-indol-2-yl)(4-methyl-1-piperazinyl)methanone ([18F]5) via a Suzuki approach starting from a protected pinacol borane precursor followed by acidic hydrolysis of the t-Boc protecting group. The non-optimized radiochem. yield was 5.7 ± 1.35%, radiochem. purity was over 99%, and molar activity was 100.7 ± 34.5 GBq/μmol (n = 3). [18F]5 was stable in rat plasma for at least 4 h and was evaluated by μPET imaging and biodistribution using a unilateral quinolinic acid rat model of neuroinflammation. The time-activity curve showed that [18F]5 entered the brain immediately after i.v. injection and then left it progressively with a very low level reached from 30 min after injection. The biodistribution study showed no difference in the accumulation of [18F]5 between the lesioned and intact side of the brain and between control rats and animals pretreated with a saturating dose of JNJ-7777120 as a specific H4R antagonist. Hence, despite its in vitro nanomolar affinity for H4R, and its ability to cross the blood-brain barrier in rats, [18F]5 does not appear suitable to image in vivo the receptor by PET. The results came from multiple reactions, including the reaction of 1-Methylpiperazine(cas: 109-01-3Application of 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Application of 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Dalmijn, Joost A.; Poursat, Baptiste A. J.; van Spanning, Rob J. M.; Brandt, Bernd W.; de Voogt, Pim; Parsons, John R. published their research in Environmental Science: Water Research & Technology in 2021. The article was titled 《Influence of short- and long-term exposure on the biodegradation capacity of activated sludge microbial communities in ready biodegradability tests》.SDS of cas: 109-01-3 The article contains the following contents:

Ready biodegradability tests (RBTs) are extensively used to screen the potential of chems. to be biodegraded. The use of RBT protocols often results in large variations of test results that may lead to wrong interpretations. The present study aims to obtain a fundamental understanding of this variability. For this, we subjected the compounds 4-chloroaniline (4CA), carbamazepine (CBZ), metformin (MET), and N-methylpiperazine (NMP) to a variety of different test conditions. Inocula from five local wastewater treatment plants (WWTPs) were used in an attempt to enhance the Organization for Economic Co-operation and Development (OECD) 310 biodegradability tests. The biodegradation capacity in RBTs, community composition and adaptation of the communities were compared after one week of pre-exposure in batch and four months exposure in chemostat. The results confirm that none of the test compounds is readily biodegradable in the standard OECD 310 RBT. However, when pre-exposure under either batch or chemostat conditions was included, 4CA was degraded in some cases and less variability among different inocula was observed for the transformation of MET. Bacterial communities from the five locations were found to be significantly different in composition from one another. In addition, pre-treatment performed before the RBT significantly changed the composition of each community. Results of this experiment show that short-term pre-exposure may increase the absolute number of degraders and deserves to be further investigated as a potential method to reduce the outcome variability of RBTs. In the experiment, the researchers used 1-Methylpiperazine(cas: 109-01-3SDS of cas: 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..SDS of cas: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In 2019,Analytical Chemistry (Washington, DC, United States) included an article by Wang, Shan-Shan; Wang, Yun-Jun; Zhang, Jing; Sun, Tuan-Qi; Guo, Yin-Long. Recommanded Product: 109-01-3. The article was titled 《Derivatization Strategy for Simultaneous Molecular Imaging of Phospholipids and Low-Abundance Free Fatty Acids in Thyroid Cancer Tissue Sections》. The information in the text is summarized as follows:

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has been applied in many fields for detecting and imaging a variety of metabolites. In cancer research, this fast-growing imaging method also helps to elucidate the connection between the changes of metabolites in the microenvironment and the proliferation and survival of cancer cells. Free fatty acids (FFAs) are a vital building block of phospholipids (PLs) that can serve as a second cellular messenger and provide nutrients in the cancer microenvironment. The metabolism process of FFAs and PLs is highly relevant to the initiation and progression of different cancers. To better understand the metabolism process in cancer tissues, simultaneously detecting and imaging FFAs and PLs is essential. Despite the crucial developments that have been performed in the field of lipids imaging, FFAs and PLs have rarely been detected and imaged simultaneously in pos. ion mode with good detection sensitivity. In this work, an on-tissue derivatization method was used to add a permanently quaternary amine onto FFAs; then, the FFAs and PLs were simultaneously imaged in pos. ion mode. The derivatized FFAs are suitable for detection in pos. ion mode. In comparison with the traditional matrix and the previous derivatization method, the derivatization reagent has a higher sensitivity for imaging FFAs. In addition, for simultaneous imaging anal. of FFAs and PLs, the number of imaged FFAs and PLs is greater than that with the previous on-tissue derivatization method. This high-sensitivity on-tissue derivatization method was applied to detect and image PLs and fatty acids in thyroid cancer tissues. In the MSI experiment, FFA derivatives and PLs were imaged while mol. localization and tissue integrity were maintained. Meanwhile, the correlation between PLs and FFAs was also studied, and the results showed that the correlations between saturated FFAs of C16:0 and C18:0 and PLs are better than the correlations of unsaturated FFAs with PLs. In the part of experimental materials, we found many familiar compounds, such as 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

SDS of cas: 109-01-3In 2019 ,《Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols》 was published in Journal of the American Chemical Society. The article was written by Laudadio, Gabriele; Barmpoutsis, Efstathios; Schotten, Christiane; Struik, Lisa; Govaerts, Sebastian; Browne, Duncan L.; Noel, Timothy. The article contains the following contents:

Sulfonamides are key motifs in pharmaceuticals and agrochems., spurring the continuous development of novel and efficient synthetic methods to access these functional groups. Herein, the authors report an environmentally benign electrochem. method which enables the oxidative coupling between thiols and amines, two readily available and inexpensive commodity chems. The transformation is completely driven by electricity, does not require any sacrificial reagent or addnl. catalysts and can be carried out in only 5 min. Hydrogen is formed as a benign byproduct at the counter electrode. Owing to the mild reaction conditions, the reaction displays a broad substrate scope and functional group compatibility. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3SDS of cas: 109-01-3)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..SDS of cas: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The author of 《Synthesis and antifungal activity of 1-aminomethyl-3-[4′-(4”-fluorobenzyloxy)-benzohydrazono] isatins》 were Rastogi, Nisheeth. And the article was published in Indian Journal of Heterocyclic Chemistry in 2019. Category: piperazines The author mentioned the following in the article:

A new series of 1-aminomethyl-3-[4′-(4”-fluorobenzyloxy)benzohydrazono]isatins (Mannich bases) I [R = H, Me, morpholinomethyl, etc.] were synthesized and screened for their antifungal potential against human pathogenic fungi. The structures of the compounds were established by means of elemental anal. and spectral data (IR and 1H NMR). The experimental part of the paper was very detailed, including the reaction process of 1-Methylpiperazine(cas: 109-01-3Category: piperazines)

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 109-01-3In 2021 ,《Facile and Cost-Effective Route for the Synthesis of Simmerafil》 was published in Organic Process Research & Development. The article was written by Odilov, Abdullajon; Liu, Yin; Hu, Tianwen; Jiang, Xiangrui; Suo, Jin; Tian, Guanghui; Yang, Feipu; Shen, Jingshan. The article contains the following contents:

An improved synthesis of simmerafil, a potent PDE5 inhibitor as a clin. candidate, is described with a 38.1% overall yield and 99.7% purity. Starting from the safe and inexpensive salicylamide, the key intermediate 2-propoxybenzimidamide, which is also a potential precursor for the preparation of pyrimidinone derivatives, was effectively and conveniently obtained. The subsequent process from 2-propoxybenzimidamide to simmerafil was optimized, which makes it more amenable to scale-up.1-Methylpiperazine(cas: 109-01-3HPLC of Formula: 109-01-3) was used in this study.

1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..HPLC of Formula: 109-01-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics