Category: 1072027-36-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072027-36-1,4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine,as a common compound, the synthetic route is as follows.

Description 16; 1,1 -Dimethylethyl 4-{5-bromo-7-[2-(ethyloxy)-2-oxoethyl]-7H-pyrrolo[2,3- d]pyrimidin-4-yl}-1 -piperazinecarboxylate (D16)1 ,1-Dimethylethyl 4-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1- piperazinecarboxylate (D15, 552 mg, 1.444 mmol) was dissolved in N, N- dimethylformamide (14 ml_), cooled in an ice bath and treated with sodium hydride (60% by weight, 69.3 mg, 1.733 mmol) portionwise and stirred under argon for 15 minutes. The reaction mixture was allowed to warm to room temperature and stirred for 1 hour. Ethyl bromoacetate (0.160 ml_, 1.444 mmol) was added and the resulting mixture stirred for 1 hour. The solvent was removed under reduced pressure. The residue taken up in water, neutralised using saturated ammonium chloride and extracted with ethyl acetate (x 3). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure. The residue was purified by column chromatography eluting with a gradient of 0-50 % ethyl acetate/iso-hexane. Product containing fractions were combined and evaporated under reduced pressure to give the title compound as a white solid. LC/MS (ES+ve): [M+H]+ at m/z 468, 470 (Ci9H26BrN5O4 requires [M+H]+ at m/z 468, 470).

1072027-36-1, As the paragraph descriping shows that 1072027-36-1 is playing an increasingly important role.

Reference：
Patent; GLAXO GROUP LIMITED; WO2009/80682; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1072027-36-1, 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4a-4c (1mmol) suspended in methanol (1mL) was added 4M HCl in dioxane (5mL) and the reaction mixture was stirred for 24hat room temperature. The precipitate was filtrated, washed with diethyl ether (2¡Á5mL), and dried to obtain 5a-5c, which were used for the next step without further purification.

1072027-36-1, The synthetic route of 1072027-36-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Yang; Yin, Yanzhen; Zhang, Zhen; Li, Carrie J.; Zhang, Hui; Zhang, Daoguang; Jiang, Changying; Nomie, Krystle; Zhang, Liang; Wang, Michael L.; Zhao, Guisen; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 543 – 551;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1072027-36-1, 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE: (S)-tert-butyl-4-(5-(3-fluoropyrrolidin-l-yl)-7H-pyrrolor2,3- dlpyrimidin-4-yl) piperazine- 1 -carboxylate.Chemical Formula C19H27FN6O2 Exact Mass 390 22 1H-NMR (DMSO-d6/300 MHz): 11.44 (s, IH), 7.97 (d, J= 1.9 Hz, IH), 5.60 (d, J= 69 Hz, IH), 5.32 (s, IH), 3.66 (m, 4H), 3.36 (m, 10H), 1.38 (s, 9H). MS (ES+, m/z): 391.2 (M++., 100.0).

1072027-36-1, 1072027-36-1 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine 58497312, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SUPERGEN, INC.; WO2008/128072; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1072027-36-1, 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE: (S)-tert-butyl-4-(5-(3-fluoropyrrolidin-l-yl)-7H-pyrrolor2,3- dlpyrimidin-4-yl) piperazine- 1 -carboxylate.Chemical Formula C19H27FN6O2 Exact Mass 390 22 1H-NMR (DMSO-d6/300 MHz): 11.44 (s, IH), 7.97 (d, J= 1.9 Hz, IH), 5.60 (d, J= 69 Hz, IH), 5.32 (s, IH), 3.66 (m, 4H), 3.36 (m, 10H), 1.38 (s, 9H). MS (ES+, m/z): 391.2 (M++., 100.0).

1072027-36-1, 1072027-36-1 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine 58497312, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SUPERGEN, INC.; WO2008/128072; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072027-36-1,4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine,as a common compound, the synthetic route is as follows.,1072027-36-1

Intermediate 3 (3.5 mmol) was dissolved in 4 mL of 4N hydrogen chloride in dioxane and allowed to react at room temperature for 2 h. After completion of the reaction, a solid precipitated and was filtered to give Intermediate 4. White solid, yield 99.2%.

1072027-36-1 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine 58497312, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Shandong University; Zhao Guisen; Yu Shengping; Liu Yang; Wang Luhua; Guo Kaiwen; Hou Xianxin; (33 pag.)CN108997351; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics