Category: 103-76-4

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Formula: C6H14N2O.

Redzicka, Aleksandra;Czyznikowska, Zaneta;Wiatrak, Benita;Gebczak, Katarzyna;Kochel, Andrzej research published 《 Design and synthesis of N-substituted 3,4-pyrroledicarboximides as potential anti-inflammatory agents》, the research content is summarized as follows. The biol. activity of the newly designed and synthesized series N-substituted 3,4-pyrroledicarboximides I [R = Bu, Ph, 3-chlorophenyl; R¹ = hydroxy; R² = 1-hydroxyethyl, pyrimidin-2-yl, cyclohexyl etc.; X = C, N, O] was described. The compounds I were obtained in good yields by one-pot, three-component condensation of pyrrolo[3,4-c]pyrroles with secondary amines and an excess of formaldehyde solution in C₂H₅OH. The structural properties of the compounds I were characterized by ¹H NMR, ¹³C NMR FT-IR, MS, and elemental anal. Moreover, single crystal X-ray diffraction has been recorded for compound I [R = 3-chlorophenyl; R² = cyclohexyl; X = N]. The colorimetric inhibitor screening assay was used and obtained their potencies and inhibited COX-1 and COX-2 enzymes. According to the results, all of the tested compounds I inhibited the activity of COX-1 and COX-2. Theor. modeling was also applied to describes the binding properties of compoundsI towards COX-1 and COX-2 cyclooxygenase isoform. The data were supported by QSAR study.

Formula: C6H14N2O, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Name: N-(2-Hydroxyethyl)piperazine.

Resende, Diana I. S. P.;Almeida, Joana R.;Pereira, Sandra;Campos, Alexandre;Lemos, Agostinho;Plowman, Jeffrey E.;Thomas, Ancy;Clerens, Stefan;Vasconcelos, Vitor;Pinto, Madalena;Correia-da-Silva, Marta;Sousa, Emilia research published 《 From Natural Xanthones to Synthetic C-1 Aminated 3,4-Dioxygenated Xanthones as Optimized Antifouling Agents》, the research content is summarized as follows. In this work, the antifouling activity of a series of 24 xanthones I [R¹ = Me, CH₂Br, 4-ClC₆H₄CH₂NHCH₂, etc.; R² = H, Cl; R³ = OMe; R⁴ = OH, OMe; R5 = H, OMe], with chem. similarities to natural products, was exploited. Nine of the tested xanthones presented highly significant anti-settlement responsed against the settlement of mussel Mytilus galloprovincialis larvae and low toxicity to this macrofouling species. Addnl., xanthone I [R¹ = piperidinylmethyl; R² = H; R³ = OMe; R⁴ = OMe; R⁵ = H] exhibited a therapeutic ratio (LC₅₀/EC₅₀) >15, as required by the US Navy program attesting its suitability as natural antifouling agents. From the nine tested xanthones, none of the compounds were found to significantly inhibit the growth of the marine biofilm-forming bacterial strains tested. Insights on the antifouling mode of action suggested that these two compounds affected similar mol. targets and cellular processes in mussel larvae, including that related to mussel adhesion capacity. This work exposed for the first time the relevance of C-1 aminated xanthones with a 3,4-dioxygenated pattern of substitution as new non-toxic products to prevent marine biofouling.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Name: N-(2-Hydroxyethyl)piperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Related Products of 103-76-4.

Rezaei, Bijan;Riahi, Siavash;Gorji, Ali Ebrahimpoor research published 《 Molecular investigation of amine performance in the carbon capture process: Least squares support vector machine approach》, the research content is summarized as follows. The growing threat of global warming has raised more attention towards carbon capture. Current amine plants used for carbon removal suffer from great costs inflicted by high energy demand of the solvent regeneration step. Recently, looking for amines with proper performance in reduced temperatures has been the subject of many researches. Clearly, conducting these researches without any criterion and based only on trial and error wastes large amounts of money and time; thus, it is highly needed that the effect of different amine structural parameters be studied on the amine’s cyclic capacity. Quant. structure property relationship (QSPR) provides an effective method for predicting amines capacity for CO₂ absorption. In this work, d. functional theory (DFT) was employed for optimization of the mol. geometries, and linear and nonlinear models based on parameters related to the mol. structure are presented. The value of the square of the correlation coefficient (R²) for the MLR and SVM models are 0.894 and 0.973, resp. Developed models can be used as a criterion for amine selection. Reliability and high predictability of the models are confirmed based on statistical tests. Moreover, mechanistic interpretation of models for better understanding of the reaction mechanism of carbon capture was discussed.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Related Products of 103-76-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Synthetic Route of 103-76-4.

Sahu, Supriya;Ghosh, Surajit Kumar;Kalita, Jun Moni;Ginjupalli, Murali C.;Kranthi Raj, K. research published 《 Discovery of potential 1,3,5-Triazine compounds against strains of Plasmodium falciparum using supervised machine learning models》, the research content is summarized as follows. The Malaria burden was an escalating global encumbrance and need to be addressed with critical care. Anti-malarial drug discovery was integrated with supervised machine learning (ML) models to identify potent thiazolyl-traizine derivatives This assimilated approach of Direct Kernel-based Partial Least Squares regression (DKPLS) with molprint 2D fingerprints in Quant. Structure Activity Relationship models was utilized to map the knowledge of known actives and to design novel mols. This QSAR study had revealed the structural features required for better antimalarial activity. Two of the mols. which were designed based on the results of this QSAR study, had shown good percentage of parasitemia against both chloroquine sensitive (3D7) and chloroquine resistant (Dd2) strains of Plasmodium falciparum resp. The IC₅₀ of 201D and 204D was 3.02 and 2.17 M against chloroquine resistant Dd2 strain of Plasmodium falciparum. This result had proved the efficiency of a multidisciplinary approach of medicinal chem. and machine learning for the design of novel potent anti-malarial compounds

Synthetic Route of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. Safety of N-(2-Hydroxyethyl)piperazine.

Saini, Anu;Kumar, Sumit;Raj, Raghu;Chowdhary, Shefali;Gendrot, Mathieu;Mosnier, Joel;Fonta, Isabelle;Pradines, Bruno;Kumar, Vipan research published 《 Synthesis and antiplasmodial evaluation of 1H-1,2,3-triazole grafted 4-aminoquinoline-benzoxaborole hybrids and benzoxaborole analogues》, the research content is summarized as follows. A library of 1H-1,2,3-triazole-tethered 4-aminoquinoline-benzoxaborole hybrids as well as aryl substituted benzoxaborole analogs was synthesized and screened for their anti-plasmodial efficacy against both chloroquine-susceptibility 3D7 and chloroquine-resistant W2 strains of P. falciparum. The inclusion of quinoline core among the synthesized analogs resulted in substantial enhancement of anti-plasmodial activities. Further, the spacer of a flexible alkyl chain is marginally preferred over piperazyl-Et in inhibiting growth of P. falciparum. The most potent 4-aminoquinoline-benzoxaborole conjugate with Et as spacer exhibited IC₅₀ values of 4.15 and 3.78μM against 3D7 CQ-susceptible and W2 CQ-resistant strains of P. falciparum with lower cross resistance with Chloroquine. There was no difference in anti-plasmodial activities between the CQ-susceptible 3D7 and CQ-resistant W2 strains of P. falciparum for the benzoxaborole derivatives lacking a quinoline core.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Safety of N-(2-Hydroxyethyl)piperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Product Details of C6H14N2O.

Sarkar, Dhruba;Olejniczak, Edward T.;Phan, Jason;Coker, Jesse A.;Sai, Jiqing;Arnold, Allison;Beesetty, Yugandhar;Waterson, Alex G.;Fesik, Stephen W. research published 《 Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods》, the research content is summarized as follows. The nucleotide exchange factor Son of Sevenless (SOS) catalyzes the activation of RAS by converting it from its inactive GDP-bound state to its active GTP-bound state. Recently, we have reported the discovery of small-mol. allosteric activators of SOS1 that can increase the amount of RAS-GTP in cells. The compounds can inhibit ERK phosphorylation at higher concentrations by engaging a feedback mechanism. To further study this process, we sought different chem. matter from an NMR-based fragment screen using selective Me labeling. To aid this process, several Ile Me groups located in different binding sites of the protein were assigned and used to categorize the NMR hits into different classes. Hit to lead optimization using an iterative structure-based design paradigm resulted in compounds with improvements in binding affinity. These improved mols. of a different chem. class increase SOS1^cat-mediated nucleotide exchange on RAS and display cellular action consistent with our prior results.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Product Details of C6H14N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Electric Literature of 103-76-4.

Shahinshavali, Shaik;Deepti, K.;Vijayavardhini, Suryadevara;Kumar, Abbaraju Venkata Durga Nagendra;Sireesha, Reddymasu;Reddy, S. Pulla;Rao, M. V. Basaveswara research published 《 An alternative route to the synthesis of N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxy ethyl)piperazin-1-yl)-2-methyl pyrimidin-4-yl)amino)thiazole-5-carboxamide》, the research content is summarized as follows. The target compound, I can be achieved by coupling between 2-bromo-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide and 2-(4-(6-amino-2-methylpyrimidin-4-yl)piperazin-1-yl)ethan-1-ol.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Electric Literature of 103-76-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Recommanded Product: N-(2-Hydroxyethyl)piperazine.

Shalini;Johansen, Matt D.;Kremer, Laurent;Kumar, Vipan research published 《 Variedly connected 1,8-naphthalimide-7-chloroquinoline conjugates: Synthesis, anti-mycobacterial and cytotoxic evaluation》, the research content is summarized as follows. Synthesis, anti-mycobacterial and cytotoxic evaluation of 4-substituted 1,8-naphthalimide-7-chloroquinoline conjugates I [R = Br, piperidin-1-yl, 4-morpholinyl, 4-(2-hydroxyethyl)piperazin-1-yl; n = 2,3,4,6,8] and II connected through varied linkers in order to study their structure-activity relationship was reported. Simple alkyl chain linked conjugates showed better activity profiles without any cytotoxicity, while the inclusion of amide bond enhanced the cytotoxic tendency. Copmd. II [R¹ = piperidin-1-yl; n = 6] proved to be the most potent and non-cytotoxic with MIC₉₉ of 6.25 μg/mL and selectivity index of > 16. An interesting behavior of conjugates I and II in terms of activity and cytotoxicity was observed via switching over the nature of linker between two pharmacophores.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Recommanded Product: N-(2-Hydroxyethyl)piperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Application In Synthesis of 103-76-4.

Shalini;Lata, Shubham;Saha, Sourav Taru;Kaur, Mandeep;Awolade, Paul;Ebenezer, Oluwakemi;Singh, Parvesh;Kumar, Vipan research published 《 Tetrahydro-β-carboline-naphthalimide hybrids: synthesis and anti-proliferative evaluation on estrogen-dependent and triple-negative breast cancer cells》, the research content is summarized as follows. A series of tetrahydro-β-carboline-naphthalimide hybrids I [X = (CH₂)_n; n = 1, 2, 3; R = H, Br, 1-piperidinyl, 4-morpholinyl, 4-hydroxy-1-piperidinyl, 4-(2-hydroxyethyl)-1-piperazinyl] were designed and synthesized via an amide coupling reaction. The obtained hybrids were evaluated for their growth inhibitory potential against MCF7 and MDA-MB-231 breast cancer cell lines using MTT assay. Three of the promising hybrids with IC₅₀s < 43μM were further scrutinized for their interactions with selected target, i.e. estrogen receptor ERα. The designed template showed a decent growth inhibitory potential on breast cancer cells with high safety profile and hence, the present manuscript reveals the success rate of hybridization technique in clubbing two individual anti-cancer cores, i.e. tetrahydro-β-carboline and naphthalimide.

Application In Synthesis of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Category: piperazines.

Silalai, Patamawadee;Pruksakorn, Dumnoensun;Chairoungdua, Arthit;Suksen, Kanoknetr;Saeeng, Rungnapha research published 《 Synthesis of propargylamine mycophenolate analogues and their selective cytotoxic activity towards neuroblastoma SH-SY5Y cell line》, the research content is summarized as follows. Twenty six propargylamine mycophenolate analogs were designed and synthesized from mycophenolic acid 1 employing a key step A³-coupling reaction. Their cytotoxic activity was examined against six cancer cell lines. Four compounds exhibited selective cytotoxicity towards neuroblastoma (SH-SY5Y) cancer cells and were less toxic to normal cells in comparison to the lead compound, MPA 1 and a standard drug, ellipticine. Mol. docking results suggested that compound I is fit well in the key amino acid of three proteins (CDK9, EGFR, and VEGFR-2) as targets in cancer therapy. The propargylamine mycophenolate scaffold might be a valuable starting point for development of new neuroblastoma anticancer drugs.

Category: piperazines, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics