Category: 103-76-4

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5 mmol of N,N-dimethylglycine, 2 mmol of CuI, 20 mmol of 4,6-dichloro-2-methylpyrimidine were dissolved in 100 mL of N,N-dimethylformamide (DMF), and stirred.22 mmol of N-hydroxyethylpiperazine and 40 mmol of K3PO4 were added, and the mixture was stirred at room temperature for 40 min, and 22 mmol of 2-amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide was added with stirring. After reacting with N2 at 120 C for 6 h, 50 mL of aqueous ammonia was added to dissolve the copper salt, and extracted with 50 mL of 3 ethyl acetate. The ethyl acetate phase was combined and washed with saturated brine.The organic layer was dried over anhydrous Na 2 SO 4 .Get a rough product. The crude product was added to 100 mL of an 80% aqueous solution of ethanol, stirred, and 2 g of activated carbon was added, refluxed for 30 min, filtered while hot, and the filtrate was recrystallized overnight, filtered, and the filter cake was washed with ice-cold 80% aqueous ethanol, and dried to give a white solid 8.64. g, yield 88.41%, purity 99.92%.

103-76-4, As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Liu Zhenteng; Zhu Xuhui; Xie Youcui; (13 pag.)CN109796448; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 9 (13.0 g, 100 mmol) was weighed in 100 mL of anhydrous tetrahydrofuran (THF)Adding di-tert-butyl dicarbonate(Boc) 20) (21.8g, lOOmmol), room temperature stirring lh; TLC detection, iodine cylinder color; raw materials disappeared after the solvent was recovered l0 (23g)., 103-76-4

As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Yang Chunhao; Miao Zehong; Yue Zhizhou; Liang Yukun; Feng Jianming; Li Jiaxin; He Qian; (30 pag.)CN104250246; (2017); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: An ethanolic solution (10 mL) of sodium hydroxide (10 mmol, 0.4 g) was added to an ethanolicsolution (10 mL) of the secondary amine (10 mmol). The mixture was cooled in an ice bath; additionally,carbon disulfide (100 mmol, 6.0 mL) was added dropwise with continuous stirring for 1 h at roomtemperature. The precipitates were filtrated and washed with diethyl ether to obtain a white topale-yellow-colored product in 70-90% yield

103-76-4, 103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Hussein, Weiam; Sa?lik, Beguem Nurpelin; Levent, Serkan; Korkut, Bue?ra; Ilgin, Sinem; Oezkay, Yusuf; Kaplancikli, Zafer Asim; Molecules; vol. 23; 8; (2018);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of l-fluoro-4-nitrobenzene (4.23 g, 30 mmol, 1.0 eq.) in DMSO (40 mL) was added TEA (9.1 g, 90 mmol, 3.0 eq.) followed by 2-(piperazin-l-yl)ethanol (3.9 g, 30 mmol, 1.0 eq.) and the mixture was stirred at 90 C overnight. The mixture was poured into ice-water (400 mL), filtered and dried in vacum to afford 2-(4-(4-nitrophenyl)piperazin- l-yl)ethanol as a yellow solid (7.2 g, 95.6%)., 103-76-4

As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-Liang; WO2015/27222; (2015); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-(piperazin-l-yl)ethanol (1. 3g, 0.01 mol) and (Boc)20 (2.4 g, 0.01 1 mol) in MeOH (15 mL) was added Et3N (1.52 g, 0.015 mol). The mixture was stirred at room temperature for 3 h. The solvent was removed in vacuo. The residue was diluted with water and extracted with EtOAc (3×20 mL). The combined organic layers were washed with brine then dried over MgSC^. After filtration and concentration, the product (2 g, 87 %) was obtained as an oil. 1H NMR (300 MHz, CDC13): delta 3.74 (t, 2H, J = 5.3 Hz), 3.56 (t, 4 h, J = 5.0 Hz), 2.72 (t, 2H, J = 5.1 Hz), 2.66 (t, 4 h, J = 5.0 Hz), 1.44 s, 9H). LCMS: No molecular ion observed for desired mass., 103-76-4

The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HERMANN, Johannes Cornelius; KUGLSTATTER, Andreas; LUCAS, Matthew C.; PADILLA, Fernando; WANNER, Jutta; ZHANG, Xiaohu; WO2013/64445; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

A magnetically-stirred 70-mL fluoropolymer-lined steel autoclave was fitted with an internal thermocouple capable of determining the temperature of the liquid phase contained in the vessel, a pressure gauge, a pressure-relief valve, and a vent valve. The amine starting material, anhydrous or aqueous sodium 2-hydroxyethanesulfonate, and anhydrous or aqueous sodium hydroxide were charged to the open autoclave, which was then assembled and immersed in an electrically heated oil bath. With the vent valve closed, the stirred reaction mixture was rapidly heated to the reaction temperature and held at that temperature for the times specified in Examples 9, 10, and 13 below. The reaction mixture was then cooled to ambient temperature, the reactor opened, and the reaction product taken up in sufficient water to dissolve all solids., 103-76-4

The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Carroll, Glenn T.; Smith, Gary S.; Stringer, Gary E.; US2006/89509; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of hydroxyethyl piperazine (13 ml) in acetone (200 ml), a 10% solution of sodium hydrogencarbonate (254 ml) was added under vigorous stirring. Subsequently, the reaction mixture was cooled to 0 C. and benzyl chloroformate (17.92 ml) was added in drops. The reaction mixture was stirred for 4 hours at room temperature. After removing the acetone under vacuum, the aqueous phase was extracted with acetic acid ethyl ester (3¡Á250 ml). The combined organic phases were washed once with a saturated solution of sodium chloride, dried over sodium sulfate, filtered, concentrated and resulted in the desired product (28.2 g).MS (EI): m/z: 265 [M+H]+

103-76-4, 103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Morphochem Aktiengesellschaft Fur Kombinatorische Chemie; US2010/324030; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,103-76-4

A solution of 3,7-dichloro-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one (200 mg, 0.66 mmol), 1-(2-hydroxyethyl)piperazine (117 mg, 0.90 mmol, Aldrich) and triethylamine (0.27 mL, 1.94 mmol) in THF (3 mL) was stirred at room temperature for one hour. The reaction was partitioned between ethyl acetate and water. The layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, and solvent was removed at reduced pressure to give 7-chloro-3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one. (218 mg, 83% yield). 1H NMR (CDCl3) delta 8.48 (1H), 7.34 (1H), 4.33-4.30 (2H), 4.04-4.00 (4H), 3.76-3.72 (2H), 3.69-3.65 (2H), 3.38-3.34 (2H), 2.67-2.64 (4H), 2.62-2.58 (2H), 1.55-1.48 (2H), 0.87-0.82 (3H).

The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2007/249615; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

The 20 mmol 4, 6 – dichloro -2 – methyl pyrimidine, 35 mmol K3 PO4 Dissolved in 16 mmol 1 – butyl -3 – methyl imidazole glycine salt and stirring, adding 21 mmol N – hydroxyethyl piperazine, for 80 C reaction under 1.5 h after, cooling to room temperature, add-on enters 21 mmol2 – amino – N – (2 – chloro -6 – methyl phenyl) -5 – thiazole carboxamide, for 80 C continues reaction under 2 h, after the reaction, cooling to room temperature, the mixture extracted with ethyl ether 3 times (3 ¡Á 50 ml), the combined extraction liquid and concentrated, get the crude product (ionic liquid to the methylene chloride extraction, vacuum drying in order to remove the small amount of solvent, the residual viscous ionic liquid ethyl ether after being sufficiently washed directly used for the next reaction, without further purification). The crude product by adding 80% ethanol aqueous solution 100 ml, under stirring, by adding 2 g of activated carbon, reflux 30 min, is still hot filtration, filtrate refrigeration crystallization overnight, filtered, the filter cake of ice 80% ethanol aqueous solution washing, drying, to obtain white solid 9.01 g, yield 92.27%, purity of 99.94%., 103-76-4

As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Gao Hongjun; Zhang Hui; Ren Qingwei; (13 pag.)CN109503568; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics