Category: 103-76-4

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Reference of 103-76-4.

Bolaender, Alexander;Zatorska, Danuta;He, Huazhong;Joshi, Suhasini;Sharma, Sahil;Digwal, Chander S.;Patel, Hardik J.;Sun, Weilin;Imber, Brandon S.;Ochiana, Stefan O.;Patel, Maulik R.;Shrestha, Liza;Shah, Smit. K.;Wang, Shuo;Karimov, Rashad;Tao, Hui;Patel, Pallav D.;Martin, Ananda Rodilla;Yan, Pengrong;Panchal, Palak;Almodovar, Justina;Corben, Adriana;Rimner, Andreas;Ginsberg, Stephen D.;Lyashchenko, Serge;Burnazi, Eva;Ku, Anson;Kalidindi, Teja;Lee, Sang Gyu;Grkovski, Milan;Beattie, Bradley J.;Zanzonico, Pat;Lewis, Jason S.;Larson, Steve;Rodina, Anna;Pillarsetty, Nagavarakishore;Tabar, Viviane;Dunphy, Mark P.;Taldone, Tony;Shimizu, Fumiko;Chiosis, Gabriela research published 《 Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system》, the research content is summarized as follows. Diseases are a manifestation of how thousands of proteins interact. In several diseases, such as cancer and Alzheimer′s disease, proteome-wide disturbances in protein-protein interactions are caused by alterations to chaperome scaffolds termed epichaperomes. Epichaperome-directed chem. probes may be useful for detecting and reversing defective chaperomes. Here we provide structural, biochem., and functional insights into the discovery of epichaperome probes, with a focus on their use in central nervous system diseases. We demonstrate on-target activity and kinetic selectivity of a radiolabeled epichaperome probe in both cells and mice, together with a proof-of-principle in human patients in an exploratory single group assignment diagnostic study. The clin. study is designed to determine the pharmacokinetic parameters and the incidence of adverse events in patients receiving a single microdose of the radiolabeled probe administered by i.v. injection. In sum, we introduce a discovery platform for brain-directed chem. probes that specifically modulate epichaperomes and provide proof-of-principle applications in their use in the detection, quantification, and modulation of the target in complex biol. systems.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Reference of 103-76-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. SDS of cas: 103-76-4.

Borlinghaus, Niginia;Ansari, Tharique N.;Braje, Leon H.;Ogulu, Deborah;Handa, Sachin;Wittmann, Valentin;Braje, Wilfried M. research published 《 Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC》, the research content is summarized as follows. The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enabled nucleophilic aromatic substitution (S_NAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitated a broad functional group tolerance that was utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent revealed the greenness and sustainability of the methodol. presented herein.

SDS of cas: 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Recommanded Product: N-(2-Hydroxyethyl)piperazine.

Bos, Pieter H.;Lowry, Emily R.;Costa, Jonathon;Thams, Sebastian;Garcia-Diaz, Alejandro;Zask, Arie;Wichterle, Hynek;Stockwell, Brent R. research published 《 Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents》, the research content is summarized as follows. Disease-causing mutations in many neurodegenerative disorders lead to proteinopathies that trigger endoplasmic reticulum (ER) stress. However, few therapeutic options exist for patients with these diseases. Using an in vitro screening platform to identify compounds that protect human motor neurons from ER stress-mediated degeneration, we discovered that compounds targeting the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family are neuroprotective. The kinase inhibitor URMC-099 (compound 1) stood out as a promising lead compound for further optimization. We coupled structure-based compound design with functional activity testing in neurons subjected to ER stress to develop a series of analogs with improved MAP4K inhibition and concomitant increases in potency and efficacy. Further structural modifications were performed to enhance the pharmacokinetic profiles of the compound 1 derivatives Prostetin/12k emerged as an exceptionally potent, metabolically stable, and blood-brain barrier-penetrant compound that is well suited for future testing in animal models of neurodegeneration.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Recommanded Product: N-(2-Hydroxyethyl)piperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. Related Products of 103-76-4.

Buran, Kerem;Reis, Rengin;Sipahi, Hande;Oenen Bayram, F. Esra research published 《 Piperazine and piperidine-substituted 7-hydroxy coumarins for the development of anti-inflammatory agents》, the research content is summarized as follows. Coumarins (2H-1-benzopyran-2-one), derivatives that can be isolated from several plants, have been reported for their anticoagulant, antimicrobial, anti-inflammatory, or anticancer activity. Some of these structures are currently approved for the treatment of cardiovascular diseases, as antibiotics or as an anticancer drug. Given the great potential of this structure and the limited number of studies that focus on mols. derived from carbon 8 of the benzopyranone heterocycle, we synthesized in this project 38 coumarin derivatives by substituting carbon 8 of the benzopyran ring with some aromatic and aliphatically substituted piperidines and piperazines. As a few of these structures were already shown to exhibit some carbonic anhydrase (CA) inhibition and as CA enzymes are reported to be closely related to inflammation, the synthesized derivatives were evaluated for their anti-inflammatory activity in vitro. The results indicated that compounds 20 and 31 revealed promising anti-inflammatory activity, as they demonstrated better activity than the reference drugs.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Related Products of 103-76-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. Quality Control of 103-76-4.

Buravchenko, Galina I.;Scherbakov, Alexander M.;Dezhenkova, Lyubov G.;Bykov, Evgeny E.;Solovieva, Svetlana E.;Korlukov, Alexander A.;Sorokin, Danila V.;Monzote Fidalgo, Lianet;Shchekotikhin, Andrey E. research published 《 Discovery of derivatives of 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: novel, hypoxia-selective HIF-1α inhibitors with strong antiestrogenic potency》, the research content is summarized as follows. The synthesis of 3-phenylquinoxaline-2-carbonitrile 1,4-dioxides bearing cyclic diamine residues at positions 6 or 7 I (R = H, piperazin-1-yl, 3-methylpiperazin-1-yl, 3-aminopyrrolidin-1-yl, etc.; R¹ = F, Cl, 3-methylpiperazin-1-yl, etc.) based on the nucleophilic substitution of halogens has been described. All synthesized 6(7)-aminoquinoxaline-2-carbonitrile 1,4-dioxides I demonstrated higher cytotoxicity and hypoxia selectivity compared to the reference agent tirapazamine against breast adenocarcinoma cell lines (MCF7, MDA-MB-231). The structure and position of the diamine residue considerably affect the antiproliferative properties of the quinoxaline-2-carbonitrile 1,4-dioxides I. The introduction of a halogen atom at position 7 in the quinoxaline ring of I (R = piperazin-1-yl; R¹ = H) considerably increases the cytotoxicity of compounds I [R = piperazin-1-yl; R¹ = F, Cl] under both normoxic and hypoxic conditions. However, the most hypoxia-selective derivatives were non-halogenated 7-aminosubstituted 3-phenylquinoxaline-2-carbonitrile 1,4-dioxides I (R = H; R¹ = piperazin-1-yl, 3-methylpiperazin-1-yl, 3-aminopyrrolidin-1-yl, etc.). Of the 32 novel synthesized derivatives, I approx. some of the 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides demonstrated high antiproliferative potency against wild type leukemia cells K562 and drug-resistant subline K562/4 with the expression of p-glycoprotein (p-gp) compared to the reference agent doxorubicin, which exhibited one order of magnitude lower activity towards K562/4 cells than towards K562 cells. Lead compounds I (R = piperazin-1-yl; R¹ = F) and I [R = H; R¹ = (3S)-3-aminopyrrolidin-1-yl] inhibited HIF-1α expression and activity and induced apoptosis in hypoxic tumor cells, which was confirmed by poly(ADP-ribose)polymerase (PARP) cleavage. Moreover, I (R = piperazin-1-yl; R¹ = F) and I [R = H; R¹ = (3S)-3-aminopyrrolidin-1-yl] showed strong antiestrogenic potencies in MCF7 breast cancer cells. Thus, the described series of quinoxaline 1,4-dioxides I has high anticancer potential and good aqueous solubility Therefore, these compounds are promising for further drug development of hypoxia-targeted anticancer agents.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Quality Control of 103-76-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. HPLC of Formula: 103-76-4.

Cao, Meng;Chen, Yuxiang;Zhao, Tianming;Wei, Shangfei;Guo, Ming;Zhai, Xin research published 《 Pyrroformyl-containing 2,4-diaminopyrimidine derivatives as a new optimization strategy of ALK inhibitors combating mutations》, the research content is summarized as follows. Aiming to identify new optimization strategy effective for ALK-mutations, two series of pyrroformyl-containing 2,4-diaminopyrimidine compounds I [R¹ = methylsulfonylamino, N-methylcarbamoyl; R² = -MeO, -OH, 1-piperidyl] were designed, synthesized and evaluated for their anti-proliferative activities against three cancer cell lines in-vitro by MTT assay. The biol. evaluations on cellular assay resulted in discovery of compound I [R¹ = methylsulfonylamino; R² = hydroxyethylamino] which performed considerable activity with IC₅₀ value of 0.034μM against H2228 cell. Meanwhile, I [R¹ = methylsulfonylamino; R² = hydroxyethylamino] exhibited outstanding enzymic inhibitory potency with IC₅₀ values of 1.9 nM and 3.1 nM against ALKWT and ALKL1196M, resp., surpassing the reference ceritinib (IC₅₀ = 2.4 nM and 7.6 nM). Ultimately, the binding mode of I [R¹ = methylsulfonylamino; R² = hydroxyethylamino] with ALK was established to explore the SARs. Overall, I [R¹ = methylsulfonylamino; R² = hydroxyethylamino] was considered as a promising ALK inhibitor for mutation treatment.

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, HPLC of Formula: 103-76-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. SDS of cas: 103-76-4.

Chaudhari, Ashok;Pramanik, Chinmoy;Patil, Pradeep;Vedpathak, Hanmant;Bandishti, Mahesh;Tripathy, Narendra K.;Gurjar, Mukund K. research published 《 Identification, isolation, and characterization of two novel impurities from phenothiazine heterocycle derivative: Perphenazine and their control in the process》, the research content is summarized as follows. During the process development of perphenazine, two unknown impurities were found by high-performance liquid chromatog. (HPLC) anal. These two impurities were further identified, isolated, and characterized form the mother liquor. These two impurities were found novel in the process of perphenazine. Also the reaction conditions were controlled for com. manufacturing of perphenazine with overall good yield and minimal side reactions with control of these two novel impurities.

SDS of cas: 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Name: N-(2-Hydroxyethyl)piperazine.

Chen, Fei;Wang, Yu;Gao, Zhanfeng;Wang, Shihui;Liu, Jiuyu;Cui, Xinhua;Wang, Yuehan;Li, Zhiwei;Qin, Mingze;Liu, Yajing;Gong, Ping;Zhao, Yanfang;Hou, Yunlei research published 《 Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a sulfonyl moiety as potent dual inhibitors of PLK1 and BRD4》, the research content is summarized as follows. The simultaneous inhibition of PLK1 and BRD4 by a single mol. could lead to the development of an effective therapeutic strategy for a variety of diseases in which PLK1 and BRD4 are implicated. Herein, two series of novel pteridinone derivatives possessing a sulfonyl moiety were designed, synthesized and evaluated for their biol. activity. Most compounds exhibited moderate to excellent cytotoxic activity against HCT116, PC3 and BT474 cell lines. Among them, the most promising compound I showed high antiproliferative effects on the three cell lines with IC50 values of 0.30 μM, 1.82 μM and 1.69 μM, resp. In the enzymic assay, compound I was identified as a potent PLK1 and BRD4 dual inhibitor (PLK1 IC₅₀ = 6.3 nM, BRD4 IC5₀ = 179 nM). Further explorations in bioactivity were conducted to clarify the anticancer mechanism of compound I. The results showed that compound I obviously inhibited the proliferation of HCT116 cell lines, induced a great decrease in the mitochondrial membrane potential leading to apoptosis of HCT116 cells and arrested the G2 phase of HCT116 cells.

Name: N-(2-Hydroxyethyl)piperazine, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Product Details of C6H14N2O.

Chen, Xingmei;Dang, Limin;Yang, Hai;Huang, Xianwei;Yu, Xinliang research published 《 Machine learning-based prediction of toxicity of organic compounds towards fathead minnow》, the research content is summarized as follows. Predicting the acute toxicity of a large dataset of diverse chems. against fathead minnows (Pimephales promelas) is challenging. In this paper, 963 organic compounds with acute toxicity towards fathead minnows were split into a training set (482 compounds) and a test set (481 compounds) with an approx. ratio of 1 : 1. Only six mol. descriptors were used to establish the quant. structure-activity/toxicity relationship (QSAR/QSTR) model for 96 h pLC₅₀ through a support vector machine (SVM) along with genetic algorithm. The optimal SVM model (R² = 0.756) was verified using both internal (leave-one-out cross-validation) and external validations. The validation results (q_int² = 0.699 and q_ext² = 0.744) were satisfactory in predicting acute toxicity in fathead minnows compared with other models reported in the literature, although our SVM model has only six mol. descriptors and a large data set for the test set consisting of 481 compounds

103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Product Details of C6H14N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Category: piperazines.

Chen, Yuanguang;Du, Fangyu;Chen, Fengyang;Zhou, Qifan;Chen, Guoliang research published 《 Methyl-α- D-glucopyranoside as Green Ligand for Selective Copper-Catalyzed N-Arylation》, the research content is summarized as follows. A catalytic system containing methyl-α- D-glucopyranoside as a green ligand and copper powder utilized for N-arylation of aryl halides and aliphatic amines/azoles/aromatic amines/amino acids to afford aryl amines R-R¹ [R = 4-O₂NC₆H₄, 2-pyridyl, 2-pyrmidinyl, etc.; R¹ = pyrolidin-1-yl, morpholin-4-yl, piperdin-1-yl, etc.] and R²NHR³ [R² = Ph, 2-O₂NC₆H₄, 4-MeOC₆H₄, etc.; R³ = Ph, 4-MeOC₆H₄, 2-CO₂HC₆H₄] under mild and environmentally friendly reaction conditions was reported.

Category: piperazines, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics