New compounds and reactions of sulfonamides with amines. XXXI. Syntheses of some N-[4-[2-(acylamino)ethyl]benzenesulfonyl]-4-alkylpiperazine-1-carboxamides was written by Gajewski, Feliks;Kozakiewicz, Irena. And the article was included in Acta Poloniae Pharmaceutica in 1982.Product Details of 21867-64-1 This article mentions the following:
Nineteen title compounds I (R = Me, R1 = 2-ClC6H4, 3-ClC6H4, 2-BrC6H4, 2-MeC6H4, 4-NO2C6H4, 2,4-Cl2C6H3, 2,5-(MeO)ClC6H3, 2-furyl, pyridyl, 2-quinolyl, 2-pyrazinyl, 2-amino-3-pyrazinyl; R = Et, Pr, R1 = 2,5-(MeO)ClC6H3, 2-pyrazinyl; R = Bu, R1 = 2-pyrazinyl) were prepared as potential hypoglycemic agents. Most I were prepared by heating 4-[R1CONH(CH2)2]C6H4SO2NHCONH2 with a substituted piperazine in dioxane. I [R = Me, R1 = 2,5-(MeO)ClC6H3] was prepared from 4-[R1CONH(CH2)2]C6H4SO2NHCONHCO2Me and N-methylpiperazine in PhMe. I (R = Me, R1 = 2-pyrazinyl) was also obtained via I (R = Me, R1 = Me) which was deacetylated with aqueous NaOH and the product acylated with pyrazine-2-carboxylic acid chloride in C6H12. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Product Details of 21867-64-1).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Product Details of 21867-64-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics