Learmonth, David A. et al. published their research in Journal of Medicinal Chemistry in 2005 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).HPLC of Formula: 21867-64-1

Synthesis and Biological Evaluation of a Novel Series of “Ortho-Nitrated” Inhibitors of Catechol-O-methyltransferase was written by Learmonth, David A.;Bonifacio, Maria Joao;Soares-da-Silva, Patricio. And the article was included in Journal of Medicinal Chemistry in 2005.HPLC of Formula: 21867-64-1 This article mentions the following:

Novel regioisomeric ortho-nitrated catechols related to the catechol-O-methyltransferase (COMT) inhibitors BIA 3-202 and BIA 3-335 were synthesized and biol. evaluated. Changing the position of the nitro group from the classical meta- to the ortho-position relative to the side-chain substituent of the nitrocatechol pharmacophore exerted profound effects on selectivity and duration of COMT inhibition. 2,3,4-O2N(HO)2C6H2CO(CH2)nPh (I, n = 1-4) possessed shorter duration of action than their regioisomers, but I (n = 2) displayed reversed selectivity over BIA 3-202 at 3 and 6 h, exhibiting preferential central inhibition. In the amino-substituted series, 2,3,4-O2N(HO)2C6H2COCH2CH2R (II, R = 4-benzylpiperidino) was less peripherally selective than BIA 3-335 and short-acting, whereas II (R = decahydroquinolino, III) displayed an unprecedented combination of long-acting and selective peripheral inhibition. I (n = 2) could provide a useful tool to probe the pharmacol. utility of short-acting, centrally selective COMT inhibitors in the treatment of depression in Parkinsonian patients, and III represents a promising candidate for clin. evaluation as an adjunct to L-Dopa therapy. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1HPLC of Formula: 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).HPLC of Formula: 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics