Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides was written by Lory, Pedro M. J.;Estrella-Jimenez, Maria E.;Shashack, Matthew J.;Lokesh, Ganesh L.;Natarajan, Amarnath;Gilbertson, Scott R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Quality Control of 6-(Piperazin-1-yl)nicotinonitrile This article mentions the following:
Methods appropriate for the parallel synthesis of libraries based on the thioxanthen-9-one 10,10-dioxide scaffold are reported. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and com. available 3-carboxythioxanthen-9-one 10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alk. phosphatase reported replicon system for activity against hepatitis C virus. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0Quality Control of 6-(Piperazin-1-yl)nicotinonitrile).
6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Quality Control of 6-(Piperazin-1-yl)nicotinonitrile
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics