Synthesis and biological evaluation of 3-(pyridine-3-yl)-2-oxazolidinone derivatives as antibacterial agents was written by Jin, Bo;Wang, Tong;Chen, Jia-yi;Liu, Xiao-qing;Zhang, Yi-xin;Zhang, Xiu-ying;Sheng, Zun-lai;Yang, Hong-Liang. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Reference of 119285-07-3 This article mentions the following:
In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives I [R = (pyridin-3-yl)carbonyl, Me, N-cyclohexylcarbamoyl, etc.], II (X = F, H) was designed, synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic, morphol., kinetic studies, and mol. docking. The results demonstrated that compounds II [R = cyclohexanecarbonyl, (2E)-3-(furan-2-yl)prop-2-enoyl (III), (2E)-3-(pyridin-3-yl)prop-2-enoyl, N-(4-chlorophenyl)carbamoyl; X = F] exhibited strong antibacterial activity similar to that of linezolid toward five Gram-pos. bacteria. After observing the effect of the drug on the morphol. and growth dynamics of the bacteria, the possible modes of action were predicted by mol. docking. Furthermore, the antibiofilm activity and the potential drug resistance assay were proceeded. These compounds exhibited universal antibiofilm activity and compound III showed significant concentration-dependent inhibition of biofilm formation. Compound III also showed a stable effect on S. pneumoniae (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate (cas: 119285-07-3Reference of 119285-07-3).
tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate (cas: 119285-07-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 119285-07-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics