An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor was written by Russell, Cecilia;Lin, Andrew J. S.;Hains, Peter;Simone, Michela I.;Robinson, Phillip J.;McCluskey, Adam. And the article was included in RSC Advances in 2015.Quality Control of 1-Boc-4-(4-Nitrophenyl)piperazine This article mentions the following:
The protein kinase inhibitor CTx-0152960 (6, 2-((5-chloro-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide), and the piperazinyl analog, CTx-0294885 (7, 2-((5-chloro-2-((4-piperazin-1-ylphenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide), were prepared using a hybrid flow and microwave approach. The use of flow chem. approaches avoided the need for Boc-protection of piperidine in the key SNAr coupling with 1-fluoro-4-nitrobenzene. Microwave coupling of 4-morphilinoaniline 8 and 4-(piperazine-1-yl)aniline 9 with 2-(2,5-dichloropyrimidine-4-ylamino)-N-methylbenzamide 10, proved to be the most efficacious route to the target analogs 6 and 7. This hybrid methodol. reduced the number of synthetic steps, gave enhanced overall yields and increased atom economy through step reduction and minimal requirement for chromatog. purification, relative to the original batch synthesis approach. In the experiment, the researchers used many compounds, for example, 1-Boc-4-(4-Nitrophenyl)piperazine (cas: 182618-86-6Quality Control of 1-Boc-4-(4-Nitrophenyl)piperazine).
1-Boc-4-(4-Nitrophenyl)piperazine (cas: 182618-86-6) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Quality Control of 1-Boc-4-(4-Nitrophenyl)piperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics