Press, Jeffrey B. et al. published their research in Journal of Medicinal Chemistry in 1979 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

10-(Alkylamino)-4H-thieno[3,4-b][1,5]benzodiazepines. A novel class of potential neuroleptic agents was written by Press, Jeffrey B.;Hofmann, Corris M.;Eudy, Nancy H.;Fanshawe, William J.;Day, Ivana P.;Greenblatt, Eugene N.;Safir, Sidney R.. And the article was included in Journal of Medicinal Chemistry in 1979.Category: piperazines This article mentions the following:

Thirty title compounds I [R = H, Me, or Et and R1 = 4-methylpiperazinyl, 4-(2-hydroxethyl)piperazinyl, etc.] were synthesized via the precursor dihydro-10H-thieno[3,4-b][1,5] benzodiazepin-10-ones. I were tested for neuroleptic activity by means of the blockade of d-amphetamine lethality in aggregated mice and (or) effects on locomotor activity in rats. Antidepressant activity was studied in mice. Most I were potent neuroleptic agents with several exhibiting addnl. antidepressant activity. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Category: piperazines).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics