Hino, Katsuhiko et al. published their research in Chemical & Pharmaceutical Bulletin in 1980 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 21867-64-1

4-Phenyl-2-(1-piperazinyl)quinolines with potent antidepressant activity was written by Hino, Katsuhiko;Furukawa, Kiyoshi;Nagai, Yasutaka;Uno, Hitoshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1980.Reference of 21867-64-1 This article mentions the following:

The 2-amino-4-phenylquinolines I (R = H, Cl; NR1R2 = piperazino, 4-alkylpiperazino, NMe2, morpholino) were prepared by acetylation and cyclization of 5,2-R(H2N)C6H3COPh to the 2-quinolinones, which were chlorinated and treated with amines. Many 2-(substituted piperazinyl) derivatives I exhibited a potent antagonism to hypothermia and catalepsy induced by reserpine, as well as some inhibitory effect on locomotor activity. Some compounds to inhibited tremorine-induced tremor. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Reference of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics