Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors was written by Donnell, Andrew F.;Dollings, Paul J.;Butera, John A.;Dietrich, Arlene J.;Lipinski, Kerri K.;Ghavami, Afshin;Hirst, Warren D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Name: tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate This article mentions the following:
Substituted pyridazino[4,5-b]indolizines were identified as potent and selective PDE4B inhibitors. We describe the structure-activity relationships generated around an HTS hit that led to a series of compounds with low nanomolar affinity for PDE4B and high selectivity over the PDE4D subtype. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (cas: 373608-48-1Name: tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate).
tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (cas: 373608-48-1) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Name: tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics