Meyer, Walter E. published the artcile5-(1-Piperazinyl)-1H-1,2,4-triazol-3-amines as antihypertensive agents, Computed Properties of 71260-16-7, the publication is Journal of Medicinal Chemistry (1989), 32(3), 593-7, database is CAplus and MEDLINE.
A series of 5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines was synthesized and screened for antihypertensive and diuretic activity in spontaneously hypertensive rats (SHR). One compound, 5-[4-[(3-chlorophenyl)methyl]-1-piperazinyl]-1H-1,2,4-triazol-3-amine (I), was selected to define the mechanism of its antihypertensive activity. Studies in spontaneously hypertensive rats suggest ganglionic blocking activity. Short-lived antihypertensive activity was observed in conscious renal hypertensive dogs. Structure-activity relationships are discussed. None of the prepared and tested compounds had diuretic activity.
Journal of Medicinal Chemistry published new progress about 71260-16-7. 71260-16-7 belongs to piperazines, auxiliary class Piperazine, name is 2-Methyl-1-(piperazin-1-yl)propan-1-one, and the molecular formula is C8H16N2O, Computed Properties of 71260-16-7.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics