Guan, Cheng-bo et al. published their research in Nanchang Daxue Xuebao, Likeban in 2012 | CAS: 911705-40-3

tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate (cas: 911705-40-3) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Quality Control of tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate

The preparation of 1-Methyl-3-phenylpiperazine was written by Guan, Cheng-bo;Zhang, Xue-mei;Wei, Meng;Lai, Kun-min;Yu, Zhang-xin;Yan, Zhao-hua. And the article was included in Nanchang Daxue Xuebao, Likeban in 2012.Quality Control of tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate The following contents are mentioned in the article:

1-Methyl-3-phenylpiperazine was prepared by using Et α-Bromophenylacetate and ethylenediamine as the starting materials in the cyclization. Then with N4 protection of the Boc group, N1 methylation, N4 deprotection and reduction of amide group, 1-Methyl-3-phenylpiperazine was synthesized. The total yield is 29%. On the basis of previously reported procedure, we further modified the work-up procedure in the first step of cyclization to increase the production quality and efficiency. The modification included dissolution of the crude product obtained in CH2Cl2, and subsequent reactions with a limited amount of di-tert-butyldicarbonate followed by precipitation in THF at low temperature Our modification improved the quality of the intermediate 3-phenyl-2-piperazinone and is easily repeatable. Moreover, in the steps of N4 protection with Boc group and reduction of amide group, some changes were also made for easy application to industrial manufacturing This study involved multiple reactions and reactants, such as tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate (cas: 911705-40-3Quality Control of tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate).

tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate (cas: 911705-40-3) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Quality Control of tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics