With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
[20351 Step 1: Synthesis of (3R.55?)-tert-butyl 3 .5-dimethylpiperazine- 1 -carboxylate [20361 (2S,6R)-2,6-dimethylpiperazine (10.000 g, 87.573 mmol) and TEA (24.278 mL,175.147 mmol) were dissolved in methylene chloride (150 mL) at room temperature, and Boc2O (20.119 mL, 87.573 mmol) was added to the solution, which was then stilTed at the same temperature for 16 hours. Water was added to the reaction mixture, followed by extraction with methylene chloride. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, filtered, and then concentrated under reduced pressure. The concentrate was purified by column chromatography (silicon dioxide, 80 g cartridge; methanol methylene chloride = from 0 % to 5 %) and concentrated to afford the desired compound (15.393 g, 82.0 %) as a yellow solid.
21655-48-1, 21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; SONG, Hyeseung; LEE, Changgon; KWAK, Dalyong; LEE, Jaeyoung; BAE, Suyeal; KIM, Yuntae; BAE, Daekwon; HA, Nina; BAE, Miseon; KIM, Jihyun; WO2015/137750; (2015); A1;,
Piperazine – Wikipedia
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