Wang, Zhangqian published the artcileContact and fumigant toxicity of cinnamaldehyde and cinnamic acid and related compounds to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae), Synthetic Route of 87179-40-6, the publication is Journal of Medical Entomology (2011), 48(2), 366-371, database is CAplus and MEDLINE.
Toxicities of (E)-cinnamaldehyde and (E)-cinnamic acid and their 41 structurally related compounds to adult Dermatophagoides farinae Hughes and Dermatophagoides pteronyssinus Trouessart (Acari: Pyroglyphidae) were examined using fabric-circle contact plus fumigant and vapor-phase mortality bioassays. Results were compared with those of two acaricides, benzyl benzoate and di-Bu phthalate. In contact plus fumigant mortality bioassays, the most toxic compounds were (E)-cinnamaldehyde, Me (E)-cinnamate, cinnamyl acetate, and hydrocinnamaldehyde against adult D. farinae (17.5-23.3 mg/m2) and D. pteronyssinus (19.0-24.0 mg/m2), based on 24-h 50% lethal concentration (LC50) values. These compounds were significantly more toxic than either benzyl benzoate (LC50, 64.9 and 60.5 mg/m2) or di-Bu phthalate (218.9 and 232.3 mg/m2). The toxicity of allyl cinnamate vs. benzyl benzoate was not significantly different. Structure-activity relationship indicates that structural characteristics, such as types of functional groups, carbon skeleton, and saturation, appear to play a role in determining the compound toxicities. In vapor-phase mortality bioassays, these compounds were effective against adult D. farinae in closed, but not in open containers, indicating that their mode of delivery was largely a result of vapor action. The active compounds described merit further study as potential house dust mite control fumigants with contact action in light of global efforts to reduce the level of highly toxic synthetic acaricides in indoor environments.
Journal of Medical Entomology published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C14H20BClO2, Synthetic Route of 87179-40-6.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics