Huang, Y. published the artcileSynthesis of potent and selective dopamine D4 antagonists as candidate radioligands, Category: piperazines, the publication is Bioorganic & Medicinal Chemistry Letters (2001), 11(11), 1375-1377, database is CAplus and MEDLINE.
A series of dopamine D4 antagonists, pyridinylpyrrolyl arylpiperazines I (R = F, MeO, R1 = H; R = H, R1 = F, MeO, MeS, CF3, CH:CH2, Et, Pr, Ph), was synthesized and evaluated as potential candidates for development as positron emission tomog. (PET) radioligands. Thus, azagramine II was reacted with the corresponding arylpiperazine in xylene under reflux to give I in 45 to 82% yield. All new compounds display high affinity and selectivity for the D4 receptors and compounds I (R = H, R1 = MeO; R = MeO, R1 = H; R = H, R1 = MeS) were identified as candidates for radioligand development. The activity against serotonin receptors was also examined
Bioorganic & Medicinal Chemistry Letters published new progress about 180698-19-5. 180698-19-5 belongs to piperazines, auxiliary class Piperazine,Benzene, name is 1-Biphenyl-4-yl-piperazine, and the molecular formula is C16H18N2, Category: piperazines.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics