Capuano, Ben published the artcileSynthesis and Preliminary Pharmacological Evaluation of 4′-Arylalkyl Analogues of Clozapine. II. Effect of the Nature and Length of the Linker, Computed Properties of 87179-40-6, the publication is Australian Journal of Chemistry (2003), 56(9), 875-886, database is CAplus.
We report the synthesis of a second generation of tricyclic analogs of clozapine, investigating the length and nature of the chain between an ionizable nitrogen atom at physiol. pH and the introduced aryl moiety. The chem., structural characterization, and pharmacol. evaluation of this series of 4′-arylalkyl analogs of clozapine are described. Preliminary findings on the effects on activity of the nature and length of the linker, degree of unsaturation, and type of aryl moiety on blockade of dopamine D4 and serotonin 5-HT2A receptors are discussed and animal behavioral data for key compounds presented.
Australian Journal of Chemistry published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Computed Properties of 87179-40-6.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics