With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.
934-98-5, General procedure: General procedure: Hydroxylamine hydrochloride (1.58 mmol)and sodium hydroxide (2.65 mmol) were added to an ice-cooledsuspension of the proper ketone compound (0.53 mmol) in 10 mlof a mixture of ethanol/H2O (2:1). After stirring for 15 min at rt,the mixture was refluxed for 2 h. The ethanol was evaporatedand the alkaline aqueous solution was neutralized with 1N HCl.When possible, the obtained suspension was filtered and the aqueoussolution was extracted with CH2Cl2 and the organic layer wasdried with anhydrous Na2SO4 and evaporated to dryness. Thecrude residue was purified as indicated for each compound.
934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Barteselli, Anna; Parapini, Silvia; Basilico, Nicoletta; Mommo, Danilo; Sparatore, Anna; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5757 – 5765;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics