31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of benzyl piperazine-1 -carboxylate (500.00 mg, 2.27 mmol) in 1 ,4-Dioxane (30.00 mL) were added 37percent HCHO (77.32 mg, 2.27 mmol) and 1-ethoxyphosphonoyloxyethane (2.27 mmol). Thereaction mixture was stirred at r.t. for 30 mm and then heated at 90-100 00 for 1 h. The mixture was poured into water (100 mL) and extracted with EtOAc (100 mLx3). The combined organic phases were washed with brine (1 00 mL), dried over anhydrous Mg504 and concentrated. The residue was purified by flash column chromatography on silica gel (Petroleum Ether:EtOAc = 1:1) to afford 4.2 (700.00 mg, 1 .89 mmol, 83percent yield). MS (ESI) m/z = 371 [M¡ÂH]. 1H NMR (400 M, ODd3), oe 7.377.32 (m, 5H), 5.13 (s,2H), 4.21 4.1 1 (m, 4H), 3.55 (s, 4H), 2.82 (d, 2H, J = 116 Hz), 2.65 (m, 4H), 1.35 (m, 6H).
31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.
Reference£º
Patent; UNITY BIOTECHNOLOGY, INC.; BACKES, Bradley; W. VON GELDERN, Thomas; CHEN, Bing; (121 pag.)WO2017/101851; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics