On January 31, 2012, Hou, Jian-bo; Xie, Wen; Chen, Xiao-mei; Qian, Yan; Xi, Jun-yang; Wang, Feng; He, Jian-min; Liu, Hai-shan published an article.Application of 86393-32-0 The title of the article was Simultaneous determination of 54 drugs residues in pork by high performance liquid chromatography-tandem mass spectrometry and isotopes dilution technique. And the article contained the following:
A simultaneous method for the determination of 54 drugs residues (sulfonamides, nitroimidazoles, quinolones, macrolide antibiotics, lincosamides and praziquantel) in pork was developed and validated by high performance liquid chromatog.-tandem mass spectrometry (HPLC-MS/MS) following solid phase extraction (SPE). The extracts were dissolved and distilled with acetonitrile. After that the supernatant solution was extracted with n-hexane to remove the fat, and then cleaned up with SPE C18 cartridges. The quant. detection was performed on LC-MS/MS by multiple reaction monitoring (MRM) mode under pos. electrospray ionization (ESI+). The one precursor/two product ion transitions were used for each compound Isotopes dilution internal standard method was used to determine the residue contents in pork. The limits of quantification (LOQs) are 1.0 μg/kg (sulfonamides and nitroimidazoles), 2.0 μg/kg (quinolones and lincosamides), 3.0 μg/kg (macrolide antibiotics) and 0.3 μg/kg (praziquantel), resp. Validation parameters are determined as follow correlation coefficients, which are more than 0.991, and the recovery for each analyte ranges of 20.9%-121% with relative standard deviations (RSDs) between 2.0% and 19.8%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application of 86393-32-0
The Article related to pork drug residue hplc isotope dilution mass spectrometry, Food and Feed Chemistry: Analysis and other aspects.Application of 86393-32-0
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Piperazines – an overview | ScienceDirect Topics