On February 27, 2008, Amirov, N. K.; Egorova, S. N.; Akhmetova, T. A.; Fedorov, A. A.; Galiullina, T. N.; Karipova, R. M.; Stepanova, N. V. published a patent.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Composition and method for preparing ciprofloxacin ophthalmic ointment. And the patent contained the following:
The invention proposes an ophthalmic ointment containing ciprofloxacin hydrochloride monohydrate equivalent to the concentration 0.1-0.9% as a free base, a preserving agent, for example nipagin or nipasol, and a sterile base consisting of vaseline melt of sort “”for ophthalmic ointments”” and anhydrous lanolin. The ophthalmic ointment is prepared by melting vaseline and anhydrous lanolin and step-by-step mixing milled ciprofloxacin hydrochloride and the preserving agent with sterile base. The invention provides producing a sterile and stable ciprofloxacin-containing ophthalmic ointment used for local treatment of eye inflammatory diseases and of bacterial etiol. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
The Article related to eye ointment ciprofloxacin formulation, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics