Hashem, F. M.; Sakran, W. S.; Shaker, D. S. published an article in 2003, the title of the article was Ocular bioavailability of ciprofloxacin hydrochloride from certain ophthalmic preparations.Application of 86393-32-0 And the article contains the following content:
The bioavailability of ciprofloxacin hydrochloride (CPX-HCl) in eye tissues and aqueous humor of rabbits was studied. The selected ophthalmic preparations were ophthalmic solution (eye drops) containing hydroxy Pr Me cellulose (HPMC), ophthalmic gels prepared with HPMC or Me cellulose (MC) or sodium alginate. Ocular inserts were prepared from HPMC, or MC or Eudragit RS. The time for peak concentration (tmax) of the drug in the eye tissues and aqueous humor was attained after one hour from the ophthalmic solution, while it was two hours in case of ophthalmic gels irresp. to polymer type. Ocular inserts prepared from HPMC or MC also showed peak concentration time of two hours after application in the rabbit’s eyes. However, the tmax was reached after three hours from Eudragit RS ocular inserts. In all tested ophthalmic formulations. CPX-HCL was available in conjunctiva in a higher concentration than in the cornea, while iris-ciliary body and aqueous humor showed less drug concentration at all time intervals. The corneal drug bioavailability represented by the area under the curve (AUC)0-5 was greatly improved after the application of ocular inserts than other forms (solution or gel). Thus Eudragit RS ocular inserts showed the highest level of the drug bioavailability in eye tissues and aqueous humor due to prolonged retention time, whereas ophthalmic solution was rapidly uptaken and eliminated by tears from eye tissues. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application of 86393-32-0
The Article related to ciprofloxacin ophthalmic ocular bioavailability, Pharmaceuticals: Formulation and Compounding and other aspects.Application of 86393-32-0
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