On September 4, 2003, Petereit, Hans-Ulrich; Meier, Christian; Gryczke, Andreas published a patent.Product Details of 86393-32-0 The title of the patent was Melt extrusion consisting of salts of active ingredients and (meth)acrylate copolymer. And the patent contained the following:
The invention relates to a method for producing active ingredient-containing granules or powders involving the following steps: (a) melting a mixture consisting of a pharmaceutically active ingredient and of a (meth)acrylate copolymer, which is comprised of 40-75 weight% of radically polymerized C1-4 alkyl esters of acrylic acid or of methacrylic acid and can be comprised of 25-60 weight% (meth)acrylate monomers having an anionic group in the alkyl radial; (b) extruding the mixture, and; (c) comminuting the extrudate to form a granule or powder. The inventive method is characterized in that the active ingredient is the salt of an alk. substance, and in that the pH value, which can be measured on the obtained powder or granule, is equal to or less than pH 7.0. The invention also relates to pharmaceutical dosage forms or precursors thereof, which can be produced using the inventive method. Thus a hot melt compound was prepared by coextruding 50 mass parts Verapamil HCl and 50 mass parts Eudragit L 100-55, then 160 g of the ground hot melt compound was mixed with 230 g lactose, 180 g Avicel PH 102, 30 g Explotab and 3 g magnesium stearate and pressed to tablets. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Product Details of 86393-32-0
The Article related to melt extrusion coextrusion salt drug methacrylate copolymer verapamil hydrochloride, Pharmaceuticals: Formulation and Compounding and other aspects.Product Details of 86393-32-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics