20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
500mg of4-(4-(( 1 -(3-isopropyl- 1 ,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3- enecarboxyilc acid was put into a 100 ml flask under a nitrogen atmosphere, 20 ml of dichloromethane was added thereto, and the resulting mixture was then dissolved while stirring. 0.32 ml of triethylamine, 160 mg of 1-cyclopropylpiperazine, and 510 mg of HATU were added dropwise thereto, and the mixture was stirred at 20C for an hour. After the reaction was terminated, 20 ml of dichloromethane was additionally added thereto, and the resulting organic layer was washed with 20 ml of distilled water, dried with anhydrous magnesium sulfate, concentrated, and then isolated by silica column chromatography to obtain the title compound (Amount obtained: 430 mg /Yield: 69%).1H NMR (400, CDC13): 7.31 (2H, d), 6.82 (2H, d), 6.03 (1H, m), 4.18 (2H, d), 3.82(2H, d), 3.64 (2H, m), 3.53 (2H, m), 3.12 (2H, m), 2.89 (1H, m), 2.77 (1H, m), 2.66(4H, m), 2.50 (3H, m), 2.30 (1H, m), 2.00 (5H, m), 1.67 (1H, m), 1.45 (2H, m), 1.28(6H, d), 0.49 (4H, m), 20327-23-5
20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; HYUNDAI PHARM CO., LTD.; YANG, Jin; KIM, Jin Woong; LEE, Han Kyu; KIM, Jae Hyun; SON, Chang Mo; LEE, Kyu Hwan; HWANG, Jeong Un; CHOI, Hyung Ho; KIM, Dae Hoon; RHEE, Jae Keol; (415 pag.)WO2017/78352; (2017); A1;,
Piperazine – Wikipedia
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