On June 27, 2013, Fauber, Benjamin; Rene, Olivier published a patent.Formula: C13H16N2O2 The title of the patent was Preparation of benzylsulfonamide derivatives as RORγ modulators for treatment of arthritis. And the patent contained the following:
The title compounds I [m = 0-4; n = 0-2; X1-4 = N or CRa, wherein Ra = independently H, cyano, C1-5 alkyl, etc.; R1 = independently C1-6 alkyl, halo, C1-6 alkoxy, etc.; R2 = C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-6 alkyl, etc.; R3a-3b, R4a-4b= independently H or C1-6 alkyl; A = P1, P2 or NR11R12; wherein Y = CR13 or N; Z = O, S(O)x, CR14R15, or NR16; Q = CH2, CO, C(O)NH, etc.; p = 1 or 2; q = 1-3; x = 0-2; Rb, R14 = H, C1-6 alkyl or halo; Rc = H, C1-6 alkyl, halo, etc.; R11, R13 = H or C1-6 alkyl; R12 = C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl-C1-6 alkyl; R15 = H, C1-6 alkyl, C3-6 cycloalkyl, etc.; R16 = H, C1-6 alkyl, C3-6 cycloalkyl, etc.] or pharmaceutically acceptable salts thereof were prepared Compounds I are retinoid-related orphan receptor gamma (RORγ) modulators and useful for treatment of inflammatory diseases such as arthritis. Compound II was prepared in a multi-step synthesis and displayed IC50 of 0.006 μM for RORc affinity. The experimental process involved the reaction of 4-(4-Acetylpiperazin-1-yl)benzaldehyde(cas: 890092-19-0).Formula: C13H16N2O2
The Article related to benzylsulfonamide preparation ror gamma modulator arthritis treatment, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Others and other aspects.Formula: C13H16N2O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics