55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
55121-99-8, Compound 6 A flask was charged with intermiediate 1 (150mg, 0.5 mmol), l-(4-aminobenzoyl)-4-m ethyl piperazine (109 mg, 0.5 mmol), TFA (50uL), isopropanol (3mL). The reaction was heated to 100C for 4h. The reaction mixture was basified with a saturated aqueous sodium bicarbonate solution and then was extracted with DCM/ (10 mlx3). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The crude product was purified with flash chromatography (0-10% MeOH-in DCM) to afford the desired product as light yellow solids (160 mg, 66% yield). 1H MR (400 MHz, DMSO-d6) delta 11.36 (br, 1H), 10.17 (br, 1H), 8.34 (s, 1H), 7.63 (d, J = 8.8 Hz, 2H), 7.39 (d, J = 8.8 Hz, 2H), 7.13 (d, J = 8.4 Etazeta, IotaEta), 6.96 (t, J = 7.6 Hz, 1H), 6.24 (s, 1H), 3.80-3.40 (br, 4H), 2.40 (s, 3H), 2.36-2.24 (br, 4H), 2.19 ( s, 3H); ESI-MS: calcd for (C26H24FN702) 485, found 486 (MH+).
55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; POLAT,, Tulay; WEINGARTEN, Paul; NALLAN, Laxman; ARP, Forrest; WANG, Qinwei; HO, David; (129 pag.)WO2016/138527; (2016); A1;,
Piperazine – Wikipedia
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