57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Boc-pyridazine (compound F-1, 0.558 g, 3 mmol) was weighed in 10 mL of anhydrous CH2Cl2 in a 25 mL beaker and anhydrous Na2CO3 (0.848 g, 8 mmol) was weighed into 7 mL of deionized water. Pour into a 100 mL single-mouth bottle and stir it in an ice bath for 20 min. Dissolve bromoacetyl bromide (0.568 mL, 6.6 mmol) in 10 mL of anhydrous CH2C12 and quickly drip into a single-mouth flask. Add DMAP (36.7 mg) after the addition. 0.3 mmol), stirring continued, TLC traces until starting material conversion, transfer to room temperature reaction 1 h. Extract with CH2C12 (3 X 30 mL). Combine the organic layers and dry over anhydrous Na2SO4. Chromatographic separation of CH2Cl2/MeOH=60:1, v/ nu) 598 mg (Compound G-1) was obtained as a milky white solid, yield 65%.
57260-71-6, 57260-71-6 tert-Butyl piperazine-1-carboxylate 143452, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; East China University of Science and Technology; Qian Xuhong; Xu Yufang; Jia Xiaotong; Zhu Weiping; Yang Youjun; (14 pag.)CN107619397; (2018); A;,
Piperazine – Wikipedia
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