On October 31, 2019, Platania, Chiara Bianca Maria; Lazzara, Francesca; Fidilio, Annamaria; Fresta, Claudia Giuseppina; Conti, Federica; Giurdanella, Giovanni; Leggio, Gian Marco; Salomone, Salvatore; Drago, Filippo; Bucolo, Claudio published an article.Application of 1428327-31-4 The title of the article was Blood-retinal barrier protection against high glucose damage: The role of P2X7 receptor. And the article contained the following:
Blood retinal barrier (BRB) breakdown is a hallmark of diabetic retinopathy, whose occurrence in early or later phases of the disease has not yet been completely clarified. Recent evidence suggests that hyperglycemia induces activation of the P2X7 receptor (P2X7R) leading to pericyte cell death. We herein investigated the role of P2X7R on retinal endothelial cells viability and expression of tight- and adherens-junctions following high glucose (HG) exposure. We found that HG elicited P2X7R activation and expression and release of the pro-inflammatory cytokine IL-1β in human retinal endothelial cells (HRECs). Furthermore, HG exposure caused a decrease in HRECs viability and a damage of the BRB. JNJ47965567, a P2X7R antagonist, protected HRECs from HG-induced damage (LDH release) and preserved the BRB, as shown by transendothelial elec. resistance and cell junction morphol. (ZO-1, claudin-5 and VE-cadherin). Moreover, JNJ47965567 treatment significantly decreased IL-1β expression and release, elicited by HG. These data indicate that P2X7R plays an important role to regulate BRB integrity, in particular the block of this receptor was useful to counteract the damage elicited by HG in HRECs, and warranting further clin. evaluation of P2X7R antagonists for the treatment of diabetic macular edema. The experimental process involved the reaction of N-((4-(4-Phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide(cas: 1428327-31-4).Application of 1428327-31-4
The Article related to p2x7 receptor antagonist blood retina barrier hyperglycemia diabetes retinopathy, blood retinal barrier, diabetic retinopathy, interleukin-1, p2x7 receptor antagonist, purinergic receptors and other aspects.Application of 1428327-31-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics