《Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein》 was written by Ono, Yukari; Ninomiya, Masayuki; Kaneko, Daiki; Sonawane, Amol D.; Udagawa, Taro; Tanaka, Kaori; Nishina, Atsuyoshi; Koketsu, Mamoru. Quality Control of 1-Methylpiperazine And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:
A series of quinoxaline-1,3,4-oxadiazole hybrids I [R = chloro, Ph, 4-methylpiperazin-1-yl, 4-phenylpiperazin-1-yl, etc.; R1 = hydroxy, amino, 2-phenylethoxy, etc.] were synthesized and assessed for their anticancer potential on human leukemia HL-60 cells. Although these hybrids I exerted significant inhibition of HL-60 cell proliferation, they showed high cytotoxicity on human normal cells (WI-38). Utilizing information from mol. modeling of the hybrids I to the anti-apoptotic Bcl-2 protein, substructures including Ph, piperazine, piperidine and morpholine rings were added to their frameworks. The designed compounds I successfully induced apoptotic response on HL-60 cells with low toxicity on WI-38 cells. Furthermore, RT-PCR anal. demonstrated that these compounds I predominantly inhibited Bcl-2 expression. These findings highlight the great potential for the development of synthetic quinoxaline-1,3,4-oxadiazole hybrid derivatives as proapoptotic anticancer agents. In the experiment, the researchers used 1-Methylpiperazine(cas: 109-01-3Quality Control of 1-Methylpiperazine)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Quality Control of 1-Methylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics