SDS of cas: 109-01-3In 2021 ,《Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites》 appeared in Chemical Data Collections. The author of the article were Faydy, Mohamed El; Dahaieh, Naoufal; Ounine, Khadija; Rastija, Vesna; Almalki, Faisal; Jamalis, Joazaizulfazli; Zarrouk, Abdelkader; Hadda, Taibi Ben; Lakhrissi, Brahim. The article conveys some information:
Eight new 7-substituted quinolin-8-ol derivatives were synthesized in moderate to good yields through quinolin-8-ol, and secondary amines as the starting reagents. The antimicrobial activity of this new series of heterocyclic compounds has been achieved “”in vitro”” against some bacterial strains by means of the disk method, and most of the tested compounds have shown comparable or greater antibacterial activity than nitroxoline (standard antibiotic). It was very motivating to observe that POM (Petra/Osiris/Molinspiration) bioinformatic analyses of compound 7-[(4-methylpiperazin-1-yl)methyl]quinolin-8-ol exhibited better antibacterial activity (MIC = 10μg/mL against B. subtilis bacteria), and higher drug score (DS = 0.57) compared with Nitroxoline (DS = 0.47; MIC = 20μg/mL). Mol. docking investigations were also conducted to investigate the binding affinities as well as interactions of some compounds with the target proteins. The results came from multiple reactions, including the reaction of 1-Methylpiperazine(cas: 109-01-3SDS of cas: 109-01-3)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..SDS of cas: 109-01-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics