Related Products of 85817-34-1On May 15, 2007 ,《Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2′-Substituted 6-nitroquipazines》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Lee, Jae Hak; Choi, Yong Hyun; Lim, Yoo Jin; Lee, Byoung Se; Chi, Dae Yoon; Jin, Changbae. The article conveys some information:
Five C2′-substituted 6-nitroquipazine (6-NQ) derivatives were prepared and evaluated in terms of their biol. abilities (Ki) to displace [3H]citalopram binding to serotonin transporter. The relationship between their structure and biol. activities revealed that shorter alkyl groups tend to possess higher binding affinity. Both compounds 12a (I, R1 = OH) and 12c (I, R1 = OEt) were found to have the equally highest binding affinity (Ki = 0.43 ± 0.02 nM). The results came from multiple reactions, including the reaction of (4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1Related Products of 85817-34-1)
(4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1) belongs to piperazines. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines.Related Products of 85817-34-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics